Preventive effects of vitamin C on carcinogenesis

Lee, Ki Won; Lee, Hyong Joo; Kang, Kyung Sun; Lee, Chang Yong

doi:10.1016/s0140-6736(02)07358-0

Cited by 55 publications

(46 citation statements)

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“…The rate of b-carotene bleaching was evaluated by the difference between the initial absorbance readings at 470 nm and after 120 minutes. The values of the percentage of antioxidant activity (AA %) were estimated by many physiological and anticarcinogenic activities (LEE et al, 2002;ZAMBUCHINI et al, 2008).…”

Section: B-carotene Bleaching Methodsmentioning

confidence: 99%

Synergistic and antimicrobial properties of commercial turmeric (Curcuma longa) essential oil against pathogenic bacteria

et al. 2012

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Several studies have shown the antimicrobial and antioxidant properties of turmeric (Curcuma longa), widely used in food industry as a colorant, among other functions. The aim of this study was to determine the antioxidant and antimicrobial properties of turmeric essential oil against pathogenic bacteria and to study the influence of the addition of ascorbic acid on the prevention of polyphenols oxidation. The commercial turmeric essential oil alone did not show bactericidal activity against the microorganisms studied, Listeria monocytogenes and Salmonella typhimurium, but when combined with ascorbic acid, it showed significant antibacterial activity. The highest antimicrobial activity of turmeric essential oil against Salmonella typhimurium was 15.0 ± 1.41 mm at the concentration of 2.30 mg.mL-1 of essential oil and 2.0 mg.mL-1 of ascorbic acid. With regard to Listeria monocytogenes, the largest zone of inhibition (13.7 ± 0.58 mm) was obtained at the same concentrations. The essential oil showed antioxidant activity of EC50 = 2094.172 µg.mL-1 for the DPPH radical scavenging method and 29% under the concentration of 1.667 mg.mL-1 for the β-carotene bleaching method.

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Section: B-carotene Bleaching Methodsmentioning

confidence: 99%

Synergistic and antimicrobial properties of commercial turmeric (Curcuma longa) essential oil against pathogenic bacteria

et al. 2012

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“…The drastic changes that occur in rabbits' biological functions are depression in feed intake and feed efficiency and utilisation, disturbances in metabolism of water and protein, energy and mineral balances, enzymatic reactions, hormonal secretions and blood metabolites (Marai et al, 2002 ;Elnagar, 2010). The high environmental temperature not only has adverse effects on rabbits' performance but also causes an increase in oxidative stress (Lee, 2002), which can impede disease resistance and impairs antioxidant status (Sabin et al, 2001). …”

Section: Introductionmentioning

confidence: 99%

Pomegranate peel as a natural antioxidant boosts bucks' fertility under Egyptian summer conditions

et al. 2013

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Exposure of male rabbits to heat stress during summer adversely affects their fertility, leading to major production losses. A total of 16 male rabbits were randomly divided into 4 experimental groups exposed to temperatures ranging from a high of 30.3 to a low of 27.3 °C. Animals from first to fourth groups were fed diets containing 0, 1.5, 3.0, or 4.5% pomegranate peel (PP) to evaluate the ability of PP feeding to enhance bucks' reproductive status. Pomegranate peel treatments significantly increased ejaculate volume by 19, 18 and 12%, increased seminal plasma fructose by 7, 18, and 24%, improved sperm motility by 28, 34 and 49%, increased sperm total output by 37, 69 and 102% and reduced dead sperm by 24, 32 and 64% with diets containing 1.5, 3.0 and 4.5% of PP compared to the heat stressed control animals. Seminal plasma total lipids, cholesterol and triglycerides increased while alkaline phosphatase decreased with PP treatments. Seminal plasma total antioxidant capacity increased to reach 126, 143 and 191% with diets containing 1.5, 3.0 and 4.5% of PP, while lipid peroxide (malondialdehyde) levels decreased significantly to reach around 54% of the heat stressed bucks' value with the three PP dietary doses used. It was concluded that supplementations of PP in the diet of bucks during summer season in Egypt can improve their semen characteristics, probably due to their antioxidant actions.

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“…[1][2][3][4] Many of these substances are found in oriental herbs or plants. Recently, some chemopreventive extracts of herbs or plants have been shown to be anti-tumorigenic.…”

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confidence: 99%

Ganoderma lucidum extract induces cell cycle arrest and apoptosis in MCF‐7 human breast cancer cell

Ahn

Yang

et al. 2002

Intl Journal of Cancer

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219

144

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Although the pharmacology and clinical application of water extracts of Ganoderma lucidum have been extensively documented, little is known regarding its alcohol extract. In the present study, the anti-tumor effect of an alcohol extract of Ganoderma lucidum was investigated using MCF-7 cells. We found that the alcohol extract of Ganoderma lucidum inhibited cell proliferation in a dose-and time-dependent manner, which might be mediated through up-regulation of p21/Waf1 and down-regulation of cyclin D1. Furthermore, this compound can directly induce apoptosis in MCF-7 cells, which might be mediated through up-regulation of a pro-apoptotic Bax protein and not by the immune system. Our findings suggest that there are multiple mechanisms underlying the anti-tumor effects of Ganoderma lucidum. © 2002 Wiley-Liss, Inc. Key words: ganoderma lucidum; breast cancer; cell cycle; apoptosis An increasing number of natural occurring chemical compounds have been identified to be potent in the treatment of various human diseases including cancer. 1-4 Many of these substances are found in oriental herbs or plants. Recently, some chemopreventive extracts of herbs or plants have been shown to be anti-tumorigenic. [5][6][7][8] Carcinogenesis is a multistage or multimechanism process, involving the irreversible alteration of a stem cell (the "initiation" phase), followed by the clonal proliferation of the initiated stem cell (the "promotion" phase), from which the acquisition of the invasive and metastatic phenotypes are generated (the "progression" phase). 9 Cancer prevention or therapy may be accomplished at different steps of this process by different mechanisms. Mixed extract of herbs or plants might contain different chemopreventive chemotherapeutic compounds with more than one mechanism of action, thus possessing a combination of different chemopreventive or chemotherapeutic effects. It is therefore very attractive and important to identify combination effects of mixed extract of herbs or plants.Ganoderma lucidum, an oriental fungus, has been widely used as a medical drug or health-promotion product in China and other Asian countries. The fruiting bodies and cultured mycelia of Ganoderma lucidum have been demonstrated to possess anti-tumor activities, 10 -18 immunomodulatory activities, 19 -20 and neuroactive effects. 21 Although numerous studies on the effects of water extracts of GL have been reported, 10 -16 little is known regarding its alcohol extracts. It has been reported that the alcohol extract of Ganoderma lucidum can induce cell cycle arrest at transition from G1 to S phase in HeLa-cells 17 This study was designed to further investigate the anti-tumor effects of alcohol extracts of Ganoderma lucidum and elucidate the potential mechanisms using an in vitro system. We found that the alcohol extract of Ganoderma lucidum was able to induce cell cycle arrest at G1 phase and induce apoptosis in MCF-7 cells in a time-dependent manner. The mechanisms might be mediated through up-regulation of the expression of p21/Waf1-a...

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Preventive effects of vitamin C on carcinogenesis

Cited by 55 publications

References 1 publication

Synergistic and antimicrobial properties of commercial turmeric (Curcuma longa) essential oil against pathogenic bacteria

Synergistic and antimicrobial properties of commercial turmeric (Curcuma longa) essential oil against pathogenic bacteria

Pomegranate peel as a natural antioxidant boosts bucks' fertility under Egyptian summer conditions

Ganoderma lucidum extract induces cell cycle arrest and apoptosis in MCF‐7 human breast cancer cell

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