Preventive effects of traditional Chinese medicine formula Huoxiangzhengqi against lipopolysaccharide-induced inflammatory response

Gao, Min; Zou, Zhen; Qiu, Yu; Sumayyah, Golamaully; Jiang, Xuejun; Su, Junhao; Duan, Xinhao; Chen, Chengzhi; Qiu, Jingfu

doi:10.1016/j.phymed.2022.153968

Cited by 5 publications

(2 citation statements)

References 45 publications

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“…In addition, knockdown of SOX2-OT weakened the activation of LDH and cell apoptosis in LPS-treated BEAS-2B cells, which further proved that SOX2-OT knockdown has a protective effect on LPS-mediated bronchial epithelial cell injury. Considering the complex role of NF-κB in cell inflammation and apoptosis and that LPS elicits NF-κB activation [ 27 , 28 ], our experiments further clarified that SOX2-OT depilation decreased the phosphorylation of NF-κB. Besides mediating inflammation and cell apoptosis, the NF-κB signal also participates in the expression of ICAM-1 and VCAM-1, two typical adhesion molecules that may aggravate the inflammatory response and inflammatory cell recruitment [ 29 , 30 ].…”

Section: Discussionmentioning

confidence: 99%

Depression of long non-coding RNA SOX2 overlapping transcript attenuates lipopolysaccharide-induced injury in bronchial epithelial cells via miR-455-3p/phosphatase and tensin homolog axis and phosphatidylinositol 3-kinase/protein kinase B pathway

et al. 2022

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Airway inflammation is associated with various respiratory diseases, and previous research has confirmed that long non-coding RNAs (lncRNAs) play imperative roles in inflammatory responses. However, the function of lncRNA SOX2 overlapping transcript (SOX2-OT) in airway inflammation remains enigmatic. This study aimed to investigate the effects of SOX2-OT on lipopolysaccharide (LPS)–induced cell injury in human bronchial epithelial cells, BEAS-2B, and its potential mechanisms. The results showed increased cell apoptotic ratio, production of inflammatory cytokines, higher expression of adhesion molecules and activation of NF-κB in LPS–stimulated BEAS-2B cells. In LPS–stimulated BEAS-2B cells, SOX2-OT up-regulation and miR-455-3p down-regulation emerged simultaneously. SOX2-OT knockdown or miR-455-3p over-expression restrained LPS–induced inflammation and injury. SOX2-OT sponged to miR-455-3p and functioned as a ceRNA. In addition, phosphatase and tensin homolog (PTEN) served as an endogenous target of miR-455-3p to modulate the phosphatidylinositol 3-kinase/protein kinase B (PI3K/AKT) pathway and disturb the alleviated consequence of miR-455-3p over-expression on LPS–induced BEAS-2B cell inflammation and cell injury. Our data demonstrated that SOX2-OT plays a pivotal role in LPS–induced inflammation and injury in BEAS-2B cells and exerts its function through the miR-455-3p/PTEN axis and modulation of the PI3K/AKT pathway.

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Section: Discussionmentioning

confidence: 99%

Depression of long non-coding RNA SOX2 overlapping transcript attenuates lipopolysaccharide-induced injury in bronchial epithelial cells via miR-455-3p/phosphatase and tensin homolog axis and phosphatidylinositol 3-kinase/protein kinase B pathway

et al. 2022

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“…LC-MS was used to identify the monomeric compounds in the ACE and the protocol was carried out according to previous report (Gao et al, 2022). In brief, 500 μL of ACE was diluted by adding 1 mL methanol and filtered through a 0.22 μm filter.…”

Section: Liquid Chromatography-mass Spectrometry (Lc-ms)mentioning

confidence: 99%

Asparagus cochinchinensis alleviates disturbances of lipid metabolism and gut microbiota in high-fat diet-induced obesity mice

Luo

Zhou²,

Jiang³

et al. 2022

Front. Pharmacol.

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Asparagus cochinchinensis is a valuable traditional Chinese medicine that has anti-inflammatory ability and effectively regulates the dysbiosis within the body. Obesity is usually characterized by chronic low-grade inflammation with aberrant gut microbiota. However, the role of Asparagus cochinchinensis against obesity remains unknown. Therefore, a high-fat diet (HFD)-induced obese mouse model with or without aqueous extract from Asparagus cochinchinensis root (ACE) treatment was established herein to determine whether ACE alleviated obesity and its involved mechanisms. Our results showed that ACE root administration significantly decreased the weight gain and relieved dyslipidemia induced by high-fat diet. Treatment of ACE root also improved glucose tolerance and insulin resistance in obese animal model, and remarkably decreased inflammation and lipogenesis in the liver and adipose. Moreover, administration of ACE root significantly reshaped the gut microbiota of obese mice. These findings together suggest that ACE root has beneficial effect against HFD-induced obesity and will provide valuable insights for the therapeutic potential of ACE against obesity and may aid in strategy-making for weight loss.

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Purslane (Portulacae oleracea L.) polysaccharide relieves cadmium-induced colonic impairments by restricting Cd accumulation and inhibiting inflammatory responses

Han,

Tian,

Wang

et al. 2024

International Journal of Biological Macromolecules

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Preventive effects of traditional Chinese medicine formula Huoxiangzhengqi against lipopolysaccharide-induced inflammatory response

Cited by 5 publications

References 45 publications

Depression of long non-coding RNA SOX2 overlapping transcript attenuates lipopolysaccharide-induced injury in bronchial epithelial cells via miR-455-3p/phosphatase and tensin homolog axis and phosphatidylinositol 3-kinase/protein kinase B pathway

Depression of long non-coding RNA SOX2 overlapping transcript attenuates lipopolysaccharide-induced injury in bronchial epithelial cells via miR-455-3p/phosphatase and tensin homolog axis and phosphatidylinositol 3-kinase/protein kinase B pathway

Asparagus cochinchinensis alleviates disturbances of lipid metabolism and gut microbiota in high-fat diet-induced obesity mice

Purslane (Portulacae oleracea L.) polysaccharide relieves cadmium-induced colonic impairments by restricting Cd accumulation and inhibiting inflammatory responses

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