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“…The synthesis of ME3738 (Fig. 1) has been described 11. We obtained ME3738 and IFN‐α 2b from Meiji Seika (Yokohama, Japan) and from Schering‐Plough (Kenilworth, NJ), respectively.…”
Section: Methodsmentioning
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“…The synthesis of ME3738 (Fig. 1) has been described 11. We obtained ME3738 and IFN‐α 2b from Meiji Seika (Yokohama, Japan) and from Schering‐Plough (Kenilworth, NJ), respectively.…”
Section: Methodsmentioning
“…In its 13 C NMR spectrum the carbonyl carbon was detected at  = 202.4 ppm. Reaction of 11 with hydroxylammonium chloride in dry pyridine 26 at 50 °C for 3 h gave 78% of the oxime 12. This oxime showed in its IR spectrum the C=N valence vibrational band at  = 1640 cm -1 , and in the 13 C NMR spectrum C-24 was detected at  = 154.5 ppm.…”
Section: Resultsmentioning
“…ME3738 (22b-methoxyolean-12-ene-3b, 24-diol), a derivative of soyasapogenol B [7], attenuates liver disease in several animal models of acute and chronic liver injury induced by concanavalin A, ethanol, lithocholate, and bile duct ligation [8][9][10][11][12]. ME3738 induces interleukin (IL)-6 expression, and serum amyloid A and immune system receptors, including RIG-I.…”
Section: Introductionmentioning