Preventive effects of green tea against liver oxidative DNA damage and hepatotoxicity in rats treated with 2-nitropropane

التأثيرات الوقائية المحتملة لأوراق القرنبيط وجلد ثمار التين الشوکي على اضطرابات الکبد التي يسببها رابع کلوريد الکربون في الفئران

“…Several studies have shown that MLP has a strong antioxidant activity, reducing lipid peroxidation and oxidative stress in a variety of organs and tissues, including the liver (89) . These findings, along with those of others, suggested that intracellular structural breakdown and an increase in lipid peroxide content could limit GSH secretion from the liver to the bloodstream (90) . MLP was defined by its increased level of antioxidative phytochemicals such as carotenoids, quercetin, flavonoids, and phenolics as well as anticarcinogenic properties (91) .…”

التأثيرات الوقائية المحتملة لأوراق القرنبيط وجلد ثمار التين الشوکي على اضطرابات الکبد التي يسببها رابع کلوريد الکربون في الفئران

“…Several studies have shown that MLP has a strong antioxidant activity, reducing lipid peroxidation and oxidative stress in a variety of organs and tissues, including the liver (89) . These findings, along with those of others, suggested that intracellular structural breakdown and an increase in lipid peroxide content could limit GSH secretion from the liver to the bloodstream (90) . MLP was defined by its increased level of antioxidative phytochemicals such as carotenoids, quercetin, flavonoids, and phenolics as well as anticarcinogenic properties (91) .…”

Oxidative Decay of DNA

“…Merely to cite the most recent results, elevated DNA oxidation has been measured during early Helicobacter pylori infection (stomach cancer (66)), ferric nitrilotriacetate administration (experimental rodent renal cancer (67)), smoking (lung cancer (17,68)), and exposure to diesel exhaust particles (lung cancer (69)), asbestos (lung cancer (70)), benzene (leukemia (71,72)), and aflatoxin (liver cancer (73)). Some studies have provided more than a simple association between carcinogenic agents and oxidative DNA damage by measuring the specific induction of repair enzymes by oxidative carcinogens (74) and by demonstrating the suppression of carcinogenesis by administration of antioxidants (21,75). The latter results are consistent with the strong correlation between a high intake of fruits and vegetables, which are the principal source of dietary antioxidants, and reduction in cancer risk by as much as half (1,7).…”

الوقایة الکیمیائیة المحتماة من اضطرابات الکبد بواسطة الکرکمین الغذائی فى الفئران المعاملة بالبنزوبیرین

“…On the other hand, serum lipid peroxide levels dropped in all B[a]P-treated animals. Such data with the others (Hasegawa et al, 1995) suggested that secretion of lipoprotein from liver to blood might be blocked because of intracellular structural failure and/or because of the energy depletion suggested by the marked decrease in glycogen content. The increases of serum enzyme activities were clearly inhibited by curcumin at this time.…”

“…These data indicated that curcumin was induced an effective role in manipulation of the serum TG content induced by B[a]P in rats. In similar study carried out by Hasegawa et al, (1995) found that previous drinking of green tea clearly protected against the changes in serum triglycerides level. Also Fayez (2015) found that curcumin lowers the atherogenic risks by reducing the insulin resistance, triglyceride, visceral fat and total body fat.…”

التأثيرات الوقائية المحتملة لأوراق القرنبيط وجلد ثمار التين الشوکي على اضطرابات الکبد التي يسببها رابع کلوريد الکربون في الفئران

“…Several studies have shown that MLP has a strong antioxidant activity, reducing lipid peroxidation and oxidative stress in a variety of organs and tissues, including the liver (89) . These findings, along with those of others, suggested that intracellular structural breakdown and an increase in lipid peroxide content could limit GSH secretion from the liver to the bloodstream (90) . MLP was defined by its increased level of antioxidative phytochemicals such as carotenoids, quercetin, flavonoids, and phenolics as well as anticarcinogenic properties (91) .…”

Oxidative Decay of DNA

“…Merely to cite the most recent results, elevated DNA oxidation has been measured during early Helicobacter pylori infection (stomach cancer (66)), ferric nitrilotriacetate administration (experimental rodent renal cancer (67)), smoking (lung cancer (17,68)), and exposure to diesel exhaust particles (lung cancer (69)), asbestos (lung cancer (70)), benzene (leukemia (71,72)), and aflatoxin (liver cancer (73)). Some studies have provided more than a simple association between carcinogenic agents and oxidative DNA damage by measuring the specific induction of repair enzymes by oxidative carcinogens (74) and by demonstrating the suppression of carcinogenesis by administration of antioxidants (21,75). The latter results are consistent with the strong correlation between a high intake of fruits and vegetables, which are the principal source of dietary antioxidants, and reduction in cancer risk by as much as half (1,7).…”

الوقایة الکیمیائیة المحتماة من اضطرابات الکبد بواسطة الکرکمین الغذائی فى الفئران المعاملة بالبنزوبیرین

“…On the other hand, serum lipid peroxide levels dropped in all B[a]P-treated animals. Such data with the others (Hasegawa et al, 1995) suggested that secretion of lipoprotein from liver to blood might be blocked because of intracellular structural failure and/or because of the energy depletion suggested by the marked decrease in glycogen content. The increases of serum enzyme activities were clearly inhibited by curcumin at this time.…”

“…These data indicated that curcumin was induced an effective role in manipulation of the serum TG content induced by B[a]P in rats. In similar study carried out by Hasegawa et al, (1995) found that previous drinking of green tea clearly protected against the changes in serum triglycerides level. Also Fayez (2015) found that curcumin lowers the atherogenic risks by reducing the insulin resistance, triglyceride, visceral fat and total body fat.…”

التأثيرات الوقائية المحتملة لأوراق القرنبيط وجلد ثمار التين الشوکي على اضطرابات الکبد التي يسببها رابع کلوريد الکربون في الفئران

“…Several studies have shown that MLP has a strong antioxidant activity, reducing lipid peroxidation and oxidative stress in a variety of organs and tissues, including the liver (89) . These findings, along with those of others, suggested that intracellular structural breakdown and an increase in lipid peroxide content could limit GSH secretion from the liver to the bloodstream (90) . MLP was defined by its increased level of antioxidative phytochemicals such as carotenoids, quercetin, flavonoids, and phenolics as well as anticarcinogenic properties (91) .…”

Oxidative Decay of DNA

“…Merely to cite the most recent results, elevated DNA oxidation has been measured during early Helicobacter pylori infection (stomach cancer (66)), ferric nitrilotriacetate administration (experimental rodent renal cancer (67)), smoking (lung cancer (17,68)), and exposure to diesel exhaust particles (lung cancer (69)), asbestos (lung cancer (70)), benzene (leukemia (71,72)), and aflatoxin (liver cancer (73)). Some studies have provided more than a simple association between carcinogenic agents and oxidative DNA damage by measuring the specific induction of repair enzymes by oxidative carcinogens (74) and by demonstrating the suppression of carcinogenesis by administration of antioxidants (21,75). The latter results are consistent with the strong correlation between a high intake of fruits and vegetables, which are the principal source of dietary antioxidants, and reduction in cancer risk by as much as half (1,7).…”

الوقایة الکیمیائیة المحتماة من اضطرابات الکبد بواسطة الکرکمین الغذائی فى الفئران المعاملة بالبنزوبیرین

“…On the other hand, serum lipid peroxide levels dropped in all B[a]P-treated animals. Such data with the others (Hasegawa et al, 1995) suggested that secretion of lipoprotein from liver to blood might be blocked because of intracellular structural failure and/or because of the energy depletion suggested by the marked decrease in glycogen content. The increases of serum enzyme activities were clearly inhibited by curcumin at this time.…”

“…These data indicated that curcumin was induced an effective role in manipulation of the serum TG content induced by B[a]P in rats. In similar study carried out by Hasegawa et al, (1995) found that previous drinking of green tea clearly protected against the changes in serum triglycerides level. Also Fayez (2015) found that curcumin lowers the atherogenic risks by reducing the insulin resistance, triglyceride, visceral fat and total body fat.…”