Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1

Citation Types

0
8
0
2

Year Published

2017
2017
2020
2020

Publication Types

Select...
5

Relationship

0
5

Authors

Journals

citations
Cited by 14 publications
(10 citation statements)
references
References 65 publications
(10 reference statements)
0
8
0
2
Order By: Relevance
“…On the other hand, we demonstrated that l-carnitine supplementation was able to increase methylation in the D-loop region of platelets mtDNA significantly, and these increased levels were associated with an improved lipid profile (increased HDL-c, reduced TG) in the same group. No other studies investigated mtDNA methylation following training and l-carnitine supplementation, while previous evidence suggested positive effects of training [66,67] and l-carnitine [68] on platelets functions. Moreover, L-carnitine has a fundamental importance for cells and mitochondrial functionality [51], and thus it has a pivotal role for the cardiovascular system health [69].…”
Section: Discussionmentioning
confidence: 99%
“…On the other hand, we demonstrated that l-carnitine supplementation was able to increase methylation in the D-loop region of platelets mtDNA significantly, and these increased levels were associated with an improved lipid profile (increased HDL-c, reduced TG) in the same group. No other studies investigated mtDNA methylation following training and l-carnitine supplementation, while previous evidence suggested positive effects of training [66,67] and l-carnitine [68] on platelets functions. Moreover, L-carnitine has a fundamental importance for cells and mitochondrial functionality [51], and thus it has a pivotal role for the cardiovascular system health [69].…”
Section: Discussionmentioning
confidence: 99%
“…Even though L-carnitine binds to all chain-lengths of fatty acids, it is only the most abundant form of long-chain fatty acids that are dependent on L-carnitine for transportation to the mitochondria [ 32 ]. However, intramitochondrial L-carnitine can export both short-chain and medium-chain acyl-CoA out of the mitochondria, that otherwise could lead to the production of free radicals which can destabilize the cell membrane; thus a reduced level of L-carnitine may lead to oxidative damage [ 33 , 34 ]. Both the tissue and the plasma will have a significant free and bound pool of L-carnitine.…”
Section: The Importance Of L-carnitinementioning
confidence: 99%
“…Since dietary L-carnitine induces TMAO elevation in human blood [1921], it has been suggested that L-carnitine increases atherosclerosis [12]. On the contrary, L-carnitine treatment has been demonstrated to attenuate the development of endothelial dysfunction in spontaneously hypertensive rats [22, 23] and many studies presented L-carnitine as an antioxidant effectively scavenging ROS in various in vitro and in vivo models [24].…”
Section: Introductionmentioning
confidence: 99%