Preventive Effect of an Infusion of the Aqueous Extract of Chaya Leaves (Cnidoscolus aconitifolius) in an Aberrant Crypt Foci Rat Model Induced by Azoxymethane and Dextran Sulfate Sodium

Comparison of Phytochemical Composition and Untargeted Metabolomic Analysis of an Extract from Cnidoscolus aconitifolius (Mill.) I. I. Johnst and Porophyllum ruderale (Jacq.) Cass. and Biological Cytotoxic and Antiproliferative Activity In Vitro

“…For C. aconitifolius particularly, its fiber (1.9 g/100 g fresh weight), P (39 mg/100 g), K (217.2 mg/100 g), Fe (11.40 mg/100 g), and ascorbic acid (164.7 mg/100 g) contents are higher than spinach, which is a commonly used plant to compare CA culinary uses and nutritional properties [ 18 ]. The results obtained in this research from TPC and TFC are similar to previously published reports for similarly prepared CA extracts (TPC: 5250 mg GAE/100 g and TFC: 416 mg CE/100 g) [ 9 ] but are higher than the values reported by Babalola and Alabi [ 19 ] (TPC: 2550 mg GAE/100 g TFC: 183.33 mg/100 g dry weight) and (TFC: 33.29 mg CE/100 g fresh weight) [ 20 ]. Regarding PR, TPC contents reported in this research are higher than the values indicated by [ 3 ] (TPC: 316–391 mg GAE/100 g), although the authors prepared a 2:1 aqueous extract without stirring, which could influence the yield of released components.…”

“…For colon adenocarcinoma, particularly, CA root bark extracts have only been tested in vitro in advanced stages (human HT-29 cells). In contrast, leaf extracts have been assayed in colon cancer in vivo [ 9 ], displaying inhibition of the cancer cell proliferation of early neoplastic lesions and reduction in colonic inflammation through the involvement of β-catenin. However, additional intermediaries involving Apc and Kras genes have not yet been explored.…”

Hematoprotective and Gastroprotective Effects of Cnidoscolus aconitifolius (Linn)-Supplemented Diet in Male Wistar Rats

“…The histopathology study reveals well preserve gastric wall architecture with no serious damage to the tissues underlying them. A report on the effect of aqueous extract of Cnidoscolus aconitifolius in a rat model reveals a possible treatment in lesions on kidney, liver, and colon when the histopathological analysis was determined [58]. Direct consumption of Cnidoscolus aconitifolius leave could also protect the gastric wall architecture if taken moderately per time.…”

Edible Leafy Plants from Mexico as Sources of Antioxidant Compounds, and Their Nutritional, Nutraceutical and Antimicrobial Potential: A Review

“…Barros et al [ 75 ] pointed out that plants/young shoots of Chenopodium ambrosioides have high antioxidant activity attributed to their bioactive molecules, and the experimental results of antitumor activity by the use of infusion and methanolic extracts inhibited growth by 50% (GI 50 ) in human cell lines (MCF-7, NCI-H460, HCT-15, HeLa, HepG2) at concentrations from 287.4 to > 400 μg/mL). The consumption of Cnidoscolus aconitifolius induces a protective effect against premalignant lesions (cancer) of the colon in rats by inhibiting cell proliferation and inflammation of colon lesions through a reduction in β-catenin and cyclooxygenase 2 (COX-2) activity [ 81 ]. Additionally, extracts of polysaccharides from Portulaca oleracea reduce sarcoma 180 transplanted into mice and have a mitogenic or comitogenic effects on splenocytes in mice with sarcomas by stimulating the proliferation of spleen lymphocytes, an immune response that improves immunity.…”