Prevention of poststernotomy wound infections in obese patients by negative pressure wound therapy

Grauhan, O.; Navasardyan, Artashes; Hofmann, Michael; Müller, Peter E.; Stein, Julia; Hetzer, Roland

doi:10.1016/j.jtcvs.2012.09.040

Cited by 142 publications

(126 citation statements)

References 19 publications

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“…After removal of duplicates, 872 remained. Eighty‐three full‐text papers were retrieved for inspection, of which seven were RCTs33, 34, 35, 36, 37, 38, 39. A further six unpublished studies were identified through contact with manufacturers and by searching ClinicalTrials.gov.…”

Section: Resultsmentioning

confidence: 99%

“…(personal communication), used an NPWT device (VAC®) and six34, 35, 38, 39, including those of S. Karlakki et al . and R. Galiano et al .…”

Section: Resultsmentioning

confidence: 99%

“…No studies of home‐made NPWT devices or studies comparing two different NPWT devices were found. One of the included studies was not reported as an RCT35. However, it was reported as a prospective trial describing a kind of randomization, and therefore is classified here as an RCT.…”

Section: Resultsmentioning

confidence: 99%

“…Blinding of outcome assessment was described adequately in two studies36, 37. Three studies35, 36, including that of B. D. Crist et al . (personal communication), did not describe loss to follow‐up properly.…”

Section: Resultsmentioning

confidence: 99%

“…There did not appear to be selective reporting bias. Finally, all studies, except one35, were either sponsored or had at least one consultant of a manufacturer as co‐author.…”

Section: Resultsmentioning

confidence: 99%

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Meta-analysis of negative-pressure wound therapy for closed surgical incisions

Hyldig

Birke-Sørensen

Kruse

et al. 2016

British Journal of Surgery

196

172

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BackgroundPostoperative wound complications are common following surgical procedures. Negative‐pressure wound therapy (NPWT) is well recognized for the management of open wounds and has been applied recently to closed surgical incisions. The evidence base to support this intervention is limited. The aim of this study was to assess whether NPWT reduces postoperative wound complications when applied to closed surgical incisions.MethodsThis was a systematic review and meta‐analysis of randomized clinical trials of NPWT compared with standard postoperative dressings on closed surgical incisions.ResultsTen studies met the inclusion criteria, reporting on 1311 incisions in 1089 patients. NPWT was associated with a significant reduction in wound infection (relative risk (RR) 0·54, 95 per cent c.i. 0·33 to 0·89) and seroma formation (RR 0·48, 0·27 to 0·84) compared with standard care. The reduction in wound dehiscence was not significant. The numbers needed to treat were three (seroma), 17 (dehiscence) and 25 (infection). Methodological heterogeneity across studies led to downgrading of the quality of evidence to moderate for infection and seroma, and low for dehiscence.ConclusionCompared with standard postoperative dressings, NPWT significantly reduced the rate of wound infection and seroma when applied to closed surgical wounds. Heterogeneity between the included studies means that no general recommendations can be made yet.

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Section: Resultsmentioning

confidence: 99%

“…(personal communication), used an NPWT device (VAC®) and six34, 35, 38, 39, including those of S. Karlakki et al . and R. Galiano et al .…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

“…There did not appear to be selective reporting bias. Finally, all studies, except one35, were either sponsored or had at least one consultant of a manufacturer as co‐author.…”

Section: Resultsmentioning

confidence: 99%

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