Prevention of Non-Enzymatic Glycosylation (Glycation) : Implication in the Treatment of Diabetic Complication

Thermal Fourier Transform Infrared Technique Quickly Detects an Early Onset of Glycation-Induced Conformational Changes of Human Serum Albumin

“…Glycation (also called non-enzymatic glycosylation) is a well-known chemical modification of proteins with reducing sugars, which may occur either inside the body (endogenous glycation) or outside the body (exogenous glycation) through the covalent bonding [1][2]. The formation of these cross-linked substances is called advanced glycation end products (AGEs) [3][4].…”

“…Several studies have shown that the formation and/or accumulation of AGEs are implicated in the progression of many age-related diseases and particularly exacerbated in aging [5][6][7][8][9]. Fortunately, glycation can be prevented by the natural defense system in the human body, or by natural and synthetic inhibitors [2,[10][11][12][13]. Theoretically, any method or inhibitor that can inhibit any step of glycation process, prevent the formation of intermediate and/or AGEs, or scavenge free radicals, may effectively prevent or delay the existing diseases and related complications [2,[14][15][16].…”

“…Fortunately, glycation can be prevented by the natural defense system in the human body, or by natural and synthetic inhibitors [2,[10][11][12][13]. Theoretically, any method or inhibitor that can inhibit any step of glycation process, prevent the formation of intermediate and/or AGEs, or scavenge free radicals, may effectively prevent or delay the existing diseases and related complications [2,[14][15][16]. Some potential inhibitors of AGEs formation have been screened and attempted to act as a preventive medicine [17][18], however, only a few studies had been investigated to determine the biophysical properties of the glycated proteins after application of inhibitors [19][20][21].…”

“…All reducing sugars have been reported to react irreversibly with amino acid residues of peptides or proteins in the glycation reaction [1][2][3][4][5][6]. The glycation reaction starts with the formation of Schiff bases, and then rearranges into Amadori products.…”

Untitled

“…cancer activity 5 , anti-antioxidant activity 6 , antiinflammatory 7 , anti-diabetic and anti-glycating property 8,9,10 , antimicrobial, antiepileptic and hepatoprotective activity 11,12,13 , potential remedial action on dental and oral illness 14 , protection against cardiovascular health problem 15 , a potentate drug against neurogenerative disorders and brain damage 16 , a remedy for renal diseases including nephrolithiasis and renal damage 17 , protection against kidney damage due to morphine toxicity 18 and as a curative drug for stress-induced gastric ulcers 19 , have been reported for this medicinal plant. The objective of this study is to screen the phytochemicals and to evaluate the antibacterial potential of Nigella sativa L. seeds against ESBL positive Escherichia coli isolates.…”