Prevention of nickel subsulfide carcinogenesis by local administration of Mycobacterium bovis antigen in male F344/NCr rats

The role of oxidative damage in metal carcinogenicity

“…I observed severe inflammatory/necrotizing effects of iron powder and iron(III) chloride4 in contrast to local cell immunosuppressive effects of Ni3S2 in rat skeletal muscle (126,127). The addition of mycobacterial antigen to Ni3S2, which greatly enhances phagocytic infiltration into the target tissue, prevents Ni3S2 carcinogenesis (128). Likewise, prevention of the immunosuppressive action of Ni(II) by Mg(II) inhibits Ni3S2 carcinogenesis (127).…”

The role of oxidative damage in metal carcinogenicity

“…I observed severe inflammatory/necrotizing effects of iron powder and iron(III) chloride4 in contrast to local cell immunosuppressive effects of Ni3S2 in rat skeletal muscle (126,127). The addition of mycobacterial antigen to Ni3S2, which greatly enhances phagocytic infiltration into the target tissue, prevents Ni3S2 carcinogenesis (128). Likewise, prevention of the immunosuppressive action of Ni(II) by Mg(II) inhibits Ni3S2 carcinogenesis (127).…”

Risk assessment of nickel carcinogenicity and occupational lung cancer.

“…In contrast, the activation of NK cells may prevent nickel carcinogenicity. Recently, Kasprzak et al (37) suggested that a single intramuscular injection of Mycobacterium bovis antigen (MB) significantly reduced the tumor incidence rate resulting from nickel subsulfide administration in F344/NCr rats. This might explain the numerous active NK cells and macrophages found at the injection site of nickel and MB.…”

Study of the mechanisms of toxicity and carcinogenicity induced by metal ions

“…Increasing amounts of at least one of the many detectable damaged DNA bases were found in organs of rat and mice following in vivo exposed to Ni 2+ . Moreover, the distribution and persistence of damaged bases in the rat kidney are indicative of this organ being the target organ for nickel carcinogenesis [191,192]. Therefore, the formation of these lesions in DNA may be considered as a genotoxic event leading to cell death or mutation.…”

The role of oxidative damage in metal carcinogenicity

“…I observed severe inflammatory/necrotizing effects of iron powder and iron(III) chloride4 in contrast to local cell immunosuppressive effects of Ni3S2 in rat skeletal muscle (126,127). The addition of mycobacterial antigen to Ni3S2, which greatly enhances phagocytic infiltration into the target tissue, prevents Ni3S2 carcinogenesis (128). Likewise, prevention of the immunosuppressive action of Ni(II) by Mg(II) inhibits Ni3S2 carcinogenesis (127).…”

Risk assessment of nickel carcinogenicity and occupational lung cancer.

“…In contrast, the activation of NK cells may prevent nickel carcinogenicity. Recently, Kasprzak et al (37) suggested that a single intramuscular injection of Mycobacterium bovis antigen (MB) significantly reduced the tumor incidence rate resulting from nickel subsulfide administration in F344/NCr rats. This might explain the numerous active NK cells and macrophages found at the injection site of nickel and MB.…”

Study of the mechanisms of toxicity and carcinogenicity induced by metal ions

“…Increasing amounts of at least one of the many detectable damaged DNA bases were found in organs of rat and mice following in vivo exposed to Ni 2+ . Moreover, the distribution and persistence of damaged bases in the rat kidney are indicative of this organ being the target organ for nickel carcinogenesis [191,192]. Therefore, the formation of these lesions in DNA may be considered as a genotoxic event leading to cell death or mutation.…”

The role of oxidative damage in metal carcinogenicity

“…I observed severe inflammatory/necrotizing effects of iron powder and iron(III) chloride4 in contrast to local cell immunosuppressive effects of Ni3S2 in rat skeletal muscle (126,127). The addition of mycobacterial antigen to Ni3S2, which greatly enhances phagocytic infiltration into the target tissue, prevents Ni3S2 carcinogenesis (128). Likewise, prevention of the immunosuppressive action of Ni(II) by Mg(II) inhibits Ni3S2 carcinogenesis (127).…”

Risk assessment of nickel carcinogenicity and occupational lung cancer.

“…In contrast, the activation of NK cells may prevent nickel carcinogenicity. Recently, Kasprzak et al (37) suggested that a single intramuscular injection of Mycobacterium bovis antigen (MB) significantly reduced the tumor incidence rate resulting from nickel subsulfide administration in F344/NCr rats. This might explain the numerous active NK cells and macrophages found at the injection site of nickel and MB.…”

Study of the mechanisms of toxicity and carcinogenicity induced by metal ions

“…Increasing amounts of at least one of the many detectable damaged DNA bases were found in organs of rat and mice following in vivo exposed to Ni 2+ . Moreover, the distribution and persistence of damaged bases in the rat kidney are indicative of this organ being the target organ for nickel carcinogenesis [191,192]. Therefore, the formation of these lesions in DNA may be considered as a genotoxic event leading to cell death or mutation.…”