Prevention of iron deficiency anemia in infants and toddlers

Sundararajan, Sripriya; Rabe, Heike

doi:10.1038/s41390-020-0907-5

Cited by 90 publications

(71 citation statements)

References 95 publications

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“…Public health interventions that improve bioavailability and infant feeding practices, and increase dietary diversity recommended by the WHO include intake of micronutrients by supplementation or fortification with iron, vitamins, folic acid, and minerals, and delayed cord clamping [ 1 , 36 ]. Despite these recommendations, we observed only a minimal improvement in the prevalence of anemia in these LMICs.…”

Section: Discussionmentioning

confidence: 99%

Prevalence and changes of anemia among young children and women in 47 low- and middle-income countries, 2000-2018

Sun

Zhao

et al. 2021

eClinicalMedicine

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Background Anemia remains a major public health issue, particularly for children and women in low- and middle-income countries (LMICs). However, the current prevalence and recent changes of anemia among young children and women of reproductive age, particularly for pregnant women in different trimesters are unclear. We examined the current prevalence of anemia among children aged less than 5 years by age (6-35 months vs. 36-59 months) and women of reproductive age by pregnant status (pregnant vs. non-pregnant) and trimesters (the third vs. the second vs. the first trimester) between 2010 and 2018 and further examined changes in the prevalence from 2000-2009 to 2010-2018. Methods Data were from the cross-sectional Demographic and Health Surveys performed between 2000 and 2018. A total of 47 countries were included to examine the current prevalence of anemia (weighted prevalence and 95% confidence interval [CI]) among young children aged less than 5 years ( N = 459,785) and 46 countries among women of reproductive age ( N = 1,079,805) between 2010 and 2018. To examine changes in the prevalence of anemia, a total of 29 countries with at least two Demographic and Health Surveys performed between 2000 and 2009 (children: N = 130,772; women: N = 371,845) and 2010-2018 (children: N = 386,202; women: N = 928,889) were included. Modified Poisson regression analyses with robust error variance were used to examine changes in anemia between 2000-2009 and 2010-2018 in participants by child age (6-5 months vs. 36-59 months), women pregnant status (pregnant vs. non-pregnant), trimesters (the second or third trimester vs. the first trimester) with the adjustment for potential covariates. Findings In 47 LMICs for children aged less than 5 years between 2010 and 2018, the total prevalence of anemia was 56.5% (95% CI 56.2, 56.8). Younger children aged 6-35 months were more likely to have anemia than older children aged 36-59 months (adjusted odds ratio [OR] 1.38, 95% CI 1.36-1.39, P < 0.001). In 46 LMICs for women of reproductive age, the total prevalence was 40.4% (95% CI 40.1, 40.7). Pregnant women were more likely to have anemia than non-pregnant women (adjusted OR 1.14, 1.12-1.16, P < 0.001). Moreover, pregnant women in the third trimester (adjusted OR 1.55, 1.48-1.62, P < 0.001) and the second trimester (adjusted OR 1.51, 1.45-1.58, P < 0.001) were more likely to have anemia than those in the first trimester. Among 29 included countries, although there was a decreasing change (absolute change, relative change, and average annual rate of reduction) in young children and women between 2000-2009 and 2010-2018 in a majority of countries, the current prevalence of anemia remained at a high l...

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Section: Discussionmentioning

confidence: 99%

Prevalence and changes of anemia among young children and women in 47 low- and middle-income countries, 2000-2018

Sun

Zhao

et al. 2021

eClinicalMedicine

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“…There is ample evidence that obesity increases the risk of chronic diseases, such as cardiovascular disease, stroke, and cancer, and accounts for about 4.8% of global deaths [23]. It is worth noting that obesity can also cause a variety of metabolic syndromes, such as hypertension and diabetes.…”

Section: Discussion/conclusionmentioning

confidence: 99%

Dysregulation of Circulating miR-24-3p in Children with Obesity and Its Predictive Value for Metabolic Syndrome

2021

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Introduction: Obesity is a major risk factor for metabolic disorders in children. Therefore, it is particularly important to study the abnormal regulation of circulating miR-24-3p in obese children and its predictive value for metabolic syndrome. Methods: Serum samples were obtained from children with obesity (n = 45), obese children with metabolic syndrome (n = 52), and healthy controls (n = 50). The expression levels of miR-24-3p were detected by reverse transcription quantitative PCR. The ROC curve was used to evaluate the diagnostic value of miR-24-3p. Pearson’s correlation analysis was performed to evaluate the relationship between serum miR-24-3p and different clinical parameters. Logistic regression analysis was used to evaluate the relationship between miR-24-3p and obesity with metabolic syndrome in children. Results: The expression of miR-24-3p was the highest in obese children with metabolic syndrome. ROC results showed that miR-24-3p had the ability to distinguish healthy individuals from obese children (area under the curve [AUC] = 0.951) and can predict the occurrence of metabolic syndrome for obese children (AUC = 0.890). The expression level of miR-24-3p was positively correlated with body mass index (r = 0.817, p < 0.001), fasting blood glucose (r = 0.798, p < 0.001), triglycerides (r = 0.773, p < 0.001), systolic blood pressure (r = 0.746, p < 0.001), and diastolic blood pressure (r = 0.623, p < 0.001), respectively. Logistic regression analysis showed that miR-24-3p was an independent influence factor for the occurrence of metabolic syndrome in obese children. Discussion/Conclusion: MiR-24-3p is a potential noninvasive marker for children with obesity and has predictive value for the occurrence of metabolic syndrome.

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“…The ASDR and ASYR of CVD were 1.5 times higher in men compared with women, as shown in Figure 2 and Supplementary Table 1. In 2017, the total number of global deaths due to CVD was 9,346,335 [9,173,526,547] in men and 8,444,614 [8,266,615,992] in women. The ASYRs of men and women were 5588.63 [5428.…”

Section: Global Cvd Burden Affected By Sex and Agementioning

confidence: 99%

“…The results of GBD were first published in the World Development Report 1993 and the Disease Control Priorities in Developing Countries project (5,6), then WHO has not only undertaken a major review of the GBD 1990 with its GBD 2000 publications but also provided annual updates in the annex tables of the World Health Report (7). Thus far, the GBD concept has been used by WHO for its report on health information, and in collaboration with external scientists, WHO developed creative new methodologies for the assessment of disease burden resulting from risk factors (8). The GBD approach results in a single summary measure of morbidity, disability, and mortality, the so-called disability-adjusted life year (DALY), which brought new knowledge to the public health community.…”

Section: Introductionmentioning

confidence: 99%

Global, Regional, and National Death, and Disability-Adjusted Life-Years (DALYs) for Cardiovascular Disease in 2017 and Trends and Risk Analysis From 1990 to 2017 Using the Global Burden of Disease Study and Implications for Prevention

Lin

et al. 2021

Front. Public Health

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Background: Cardiovascular disease is the leading cause of death worldwide and a major barrier to sustainable human development. The objective of this study was to evaluate the global, sex, age, region, and country-related cardiovascular disease (CVD) burden, as well as the trends, risk factors, and implications for the prevention of CVD.Methods: Detailed information from 1990 to 2017, including global, regional, and national rates of CVD, and 11 categories of mortality and disability-adjusted life years (DALYs) were collected from the Global Burden of Disease Study 2017. The time-dependent change in the trends of CVD burdens was evaluated by annual percentage change.Results: More than 17 million people died from CVD in 2017, which was approximately two times as many as cancer, and increased nearly 50% compared with 1990. Ischemic heart disease and stroke accounted for 85% of the total age-standardized death rate (ASDR) of CVD. The ASDR and age-standardized DALYs rate (ASYR) of CVD were 1.5 times greater in men compared with women. People over the age of 50 were especially at risk for developing CVD, with the number of cases and deaths in this age group accounting for more than 90% of all age groups. CVD mortality was related to regional economic development and the social demographic index. In regions with a high economic income or socio-demographic index, there was a greater decline in the ASDR of CVD. The ASDR of CVD in high SDI regions decreased more than 50% from 1990 to 2017. Tobacco use, diets low in whole grains, diets high in sodium, and high systolic blood pressure were the important risk factors related to CVD mortality.Conclusions: CVD remains a major cause of death and chronic disability in all regions of the world. Ischemic heart disease and stroke account for the majority of deaths related to CVD. Although the mortality rate for CVD has declined in recent years from a global perspective, the results of CVD data in 2017 suggest that the mortality and DALYs of CVD varied in different ages, sexes, and countries/regions around the world. Therefore, it is necessary to elucidate the specific characteristics of global CVD burden and establish more effective and targeted prevention strategies.

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Prevention of iron deficiency anemia in infants and toddlers

Abstract: Article (Accepted Version) http://sro.sussex.ac.uk Sundararajan, Sripriya and Rabe, Heike (2020) Prevention of iron-deficiency anemia in infants and toddlers. Pediatric Research.

Cited by 90 publications

References 95 publications

Prevalence and changes of anemia among young children and women in 47 low- and middle-income countries, 2000-2018

Prevalence and changes of anemia among young children and women in 47 low- and middle-income countries, 2000-2018

Dysregulation of Circulating miR-24-3p in Children with Obesity and Its Predictive Value for Metabolic Syndrome

Global, Regional, and National Death, and Disability-Adjusted Life-Years (DALYs) for Cardiovascular Disease in 2017 and Trends and Risk Analysis From 1990 to 2017 Using the Global Burden of Disease Study and Implications for Prevention

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