2017
DOI: 10.1016/s0140-6736(17)31332-6
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Prevention of incisional hernia with prophylactic onlay and sublay mesh reinforcement versus primary suture only in midline laparotomies (PRIMA): 2-year follow-up of a multicentre, double-blind, randomised controlled trial

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Cited by 249 publications
(341 citation statements)
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“…BMI is known to affect midline incisional and parastomal hernia rates , which might be explained by higher intra‐abdominal pressure and consequent higher abdominal wall tension . Additionally, obesity and diabetes are associated with wound healing complications due to local hypoxia, caused by a decreased vascularization of adipose tissue and other microvascular changes, impairing collagen synthesis and having a negative effect on the overall healing process . Smoking has a comparable negative effect on wound healing and is considered a risk factor for incisional hernia .…”
Section: Discussionmentioning
confidence: 99%
“…BMI is known to affect midline incisional and parastomal hernia rates , which might be explained by higher intra‐abdominal pressure and consequent higher abdominal wall tension . Additionally, obesity and diabetes are associated with wound healing complications due to local hypoxia, caused by a decreased vascularization of adipose tissue and other microvascular changes, impairing collagen synthesis and having a negative effect on the overall healing process . Smoking has a comparable negative effect on wound healing and is considered a risk factor for incisional hernia .…”
Section: Discussionmentioning
confidence: 99%
“…Mesh placement is a simple surgical method that may prevent wound/fascial dehiscence and incisional hernias . However, the efficacy of preventive mesh implantation in organ transplant recipients has not been well studied; only case reports and case series investigating pediatric KTx and including less than 10 patients have been published so far .…”
Section: Discussionmentioning
confidence: 99%
“…Meshes or fascial flaps are mainly used during surgical treatment of hernias and wound and fascial dehiscence . Recently, mesh placement was investigated as a preventive method to reduce the incidence of some wound complications, including wound and fascial dehiscence and hernia after abdominal surgery . The use of preventive mesh reinforcement during KTx has also been investigated during intraperitoneal renal implantation in children .…”
Section: Introductionmentioning
confidence: 99%
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