Prevention of heart disease by control of risk factors: The time has come to face the facts

Corday, Eliot; Corday, Stephen R.

doi:10.1016/0002-9149(75)90023-5

Cited by 66 publications

(7 citation statements)

References 4 publications

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“…The only-50% claim goes back at least to 1975, and we could find no reference or published source that plausiblysupportsitwithempiricaldata.The claimconsistsofsimpleassertionswith nosupportingdataorrationale, [12][13][14][15]20,22 or assertions made with inappropriate citations. [16][17][18][19]21 In both cases, the claim has been secondarily quoted, 12,14,15,19 perpetuating the myth.…”

Section: Origin and Perpetuation Of The Only-50% Claimmentioning

confidence: 99%

“…[12][13][14][15][16][17][18][19][20][21][22] To many observers, explaining half of CHD is a great achievement in itself and is as close to a full explanation as one could usually expect, given measurement errors and other difficulties in making such estimates. However, this "only-50%" claim is often used to imply that, even if we could fully control the established CHD risk factors, we could reduce CHD incidence or death rates by half, at most.…”

mentioning

confidence: 99%

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The Real Contribution of the Major Risk Factors to the Coronary Epidemics

Magnus¹,

Beaglehole²

2001

Arch Intern Med

260

142

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Section: Origin and Perpetuation Of The Only-50% Claimmentioning

confidence: 99%

mentioning

confidence: 99%

The Real Contribution of the Major Risk Factors to the Coronary Epidemics

Magnus¹,

Beaglehole²

2001

Arch Intern Med

260

142

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“…These findings indicate that aging might be a continuous process [10]. In China arteriosclerosis was not considered to be a clinical problem in the 1930s, but today there is a high incidence of cardiovascular disease in China [11]. The Chinese diet was considered to be "non-atherogenic."…”

Section: Diet Pharmaceuticals and Agingmentioning

confidence: 99%

Diet, Aging, Microbiome, Social Well-Being, and Health

Abdulla¹

2020

Personalized Medicine, in Relation to Redox State, Diet and Lifestyle

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Over the past few decades, researchers have established that the human body has a complex ecosystem. It is a social network between our own cells and bacteria and other microorganisms. Bacteria cells in the human body outnumber our own cells by 10 to 1. Despite this huge number, they are usually no threat to us. They offer vital help to many of our basic physiological processes. It is becoming increasingly clear that the microbes in our gut play crucial roles in health and disease. It is likely that the bacterial flora in our body may also influence the aging process. Apart from the influence of bacterial flora in our bodies and the diet we consume, there are certain pharmacological substances such as rapamycin, metformin, and resveratrol that are shown to influence longevity in animals and humans. Calorie restriction is known to increase life span in many animal species. Other factors that influence aging include the role of free radicals, gene modifications, chronic inflammation, and certain spices such as curcumin and capsaicin. Modern life style that promotes obesity and social isolation are other factors that contribute to a number of human illnesses. This paper will present some of the latest findings related to gut flora, aging, and social well-being.

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“…The Framingham Heart Study established the importance of cigarette smoking, increased blood pressure, cholesterol, and diabetes mellitus as major risk factors for CVD (2,3 ), and knowledge of their absolute levels has been used to predict the 10-year and lifetime risks of CVD (2,3 ). It had been suggested, however, that the established risk factors can explain only about 50% of coronary heart disease (CHD) risk (4)(5)(6), and, although these estimates have been challenged (7,8 ), this has prompted substantial research efforts to detect "novel" or "emerging" risk factors for CVD, including biomarkers.…”

confidence: 99%

A Review on Metaanalysis of Biomarkers: Promises and Pitfalls

2012

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BACKGROUND:The last 30 years have seen an exponential increase in metaanalyses. By combining multiple studies, metaanalysis can provide an overview of the totality of evidence on a particular question and the statistical power needed to reduce random error and produce precise estimates of even modest effect sizes. This capability is of particular value when many small studies address similar questions [such as in the investigation of novel cardiovascular disease (CVD) biomarkers]. To provide reliable evidence, however, metaanalyses must be undertaken robustly.CONTENT: In this review, we describe the major issues to consider when designing and conducting metaanalyses, including the design of constituent studies, selection criteria, assessment of exposures and disease outcomes, and control of bias and confounding. Some of the potential challenges and pitfalls associated with metaanalysis are examined, and their consequences are considered. We use 2 examples of novel biomarkers for CVD-homocysteine and triglycerides-to illustrate how metaanalyses of observational studies have contributed to, and on occasion hindered, our understanding; and how subsequent work has built upon these findings.

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Prevention of heart disease by control of risk factors: The time has come to face the facts

Cited by 66 publications

References 4 publications

The Real Contribution of the Major Risk Factors to the Coronary Epidemics

The Real Contribution of the Major Risk Factors to the Coronary Epidemics

Diet, Aging, Microbiome, Social Well-Being, and Health

A Review on Metaanalysis of Biomarkers: Promises and Pitfalls

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