Prevention of endemic canine vector-borne diseases using imidacloprid 10% and permethrin 50% in young dogs: A longitudinal field study

Otranto, Domenico; Caprariis, Donato De; Lia, Riccardo P.; Tarallo, Viviana Domenica; Lorusso, Vincenzo; Testini, Gabriella; Dantas‐Torres, Filipe; Latrofa, Stefania; Diniz, Pp; Mencke, Norbert; Maggi, Ricardo G.; Breitschwerdt, Edward B.; Capelli, Gioia; Stanneck, Dorothee

doi:10.1016/j.vetpar.2010.05.017

Cited by 84 publications

(71 citation statements)

References 40 publications

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“…There was statistically significant evidence from four of the five included studies that deltamethrin collars had a protective effect , Foglia Manzillo et al, 2006, Maroli et al, 2001, and there was one non-significant result. Four of the five spot-ons studies had a significant protective effect, one using 65% permethrin , the 10% imidacloprid and 50% permethrin evaluated by Otranto et al (2010) and both the 28 ± 2 day and 14 ± 2 days treatments with 10% imidacloprid and 50% permethrin evaluated by Otranto et al (2007b). Only one of the three studies on prophylactic medication showed a statistically significant effect, with a protective effect evident from domperidone (Llinas et al, 2011).…”

Section: Summary Of Main Resultsmentioning

confidence: 95%

“…Two studies were OCTs , Giffoni et al, 2002 while Otranto et al (2007) did not conceal allocation. Otranto et al (2010) did not report sufficient information to judge this.…”

Section: Allocation Concealmentmentioning

confidence: 99%

“…Insufficient signalment data were provided to compare the populations used which were sourced in Italy and Brazil respectively, and were analysed using IFA serological methods. Otranto et al (2007) and Otranto et al (2010) The present document has been produced and adopted by the bodies identified above as author(s). This task has been carried out exclusively by the author(s) in the context of a contract between the European Food Safety Authority and the author(s), awarded following a tender procedure.…”

Section: Supporting Publications 2013:en-466 47mentioning

confidence: 99%

“…The study by Otranto et al (2010) found the largest ARR, for every 100 dogs given 10% imidacloprid and 50% permethrin 37 cases of infection with L. infantum based on serology or parasite detection would be averted. Ferroglio et al (2008) found that 14 cases per 100 dogs would be averted due to 65% permethrin while Otranto et al (2007) a and b found that 10 cases per 100 dogs would be averted due to 10% imidacloprid and 50% permethrin for both dosing regimens studied.…”

Section: Acknowledgment Of Financial Supportmentioning

confidence: 99%

“…The risk of bias for the Otranto et al (2010) paper was judged to be unclear while it was high for each of the other studies. Figure 19: Summary forest plot of the Odds Ratio and 95% confidence interval for the proportion of dogs infected with L. infantum based on serology or parasite detection for the studies judged to be the most efficacious for each intervention group.…”

Section: Overall Summarymentioning

confidence: 99%

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Data collection to characterise the impact of canine leishmaniosis and modelling of the role of animals in spreading Leishmania infantum within the European Union

Mattin

Brodbelt

Wylie

et al. 2014

EFSA Supporting Publications

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Canine leishmaniosis (CanL) is a major zoonosis transmitted by sand flies which can potentially cause severe fatal disease in humans and dogs. The disease is endemic in southern Europe and there are concerns about its introduction into the non-endemic areas of the European Union (EU). The objectives of this work were to investigate the efficacy of different control measures using a systematic review (SR), assess the role of dogs in the spread of Leishmania Infantum (L. infantum) in the EU and evaluate potential mitigation measures using simulation modelling, and evaluate the impact of the disease in endemic areas. The SR evaluated the effectiveness and safety of control measures for CanL using 23 clinical trials conducted on a total of 5861 dogs. Significant benefits were observed in the intervention groups for a number of vaccine types, deltamethrin collars, spot-ons, and prophylactic medication with domperidone. However, these results require confirmation in adequately powered well designed randomised controlled trials. The results of the stochastic simulation modelling suggest that there is a high risk of endemicity for disease-free EU regions with presence of a competent vector and where infected dogs are introduced. When evaluated individually and at a high level of implementation, the best mitigation measures in decreasing order of effectiveness were: repellent, vaccine, prophylactic medication and insecticide. Some combinations of mitigation measures showed a joint effect higher than the effect of individual measures. Test and exclusion of positive dogs moving into non-endemic areas was effective for low numbers of imports, but its benefits diminished as the number of imported dogs increased, given the low sensitivity of the diagnostic test used. The results of the impact assessment suggest clinical CanL is a common diagnosis in endemic parts of the EU. The estimated percentage of practice-attending dogs with a veterinary diagnosis of CanL by country was as follows: France 0.71%, Spain 3.71%, Portugal 2.92%, Italy 4.25% and Greece 7.80%. CanL can have a significant impact on the welfare of affected dogs and economic implications for owners, both for prevention and treatment. It is estimated that the use of preventative collars in these five countries cost dog owners €54 million in 2012 alone. The incidence of clinical human leishmaniosis is much lower than CanL, with reported data suggesting between 20 and 380 hospital admissions per country per year. Costs relating to hospital fees and time off work may amount to approximately €4.5million/year in Spain, Portugal, Italy and Greece. The current economic crisis is likely to have an adverse impact on the prevention and control of CanL.

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Section: Summary Of Main Resultsmentioning

confidence: 95%

“…Two studies were OCTs , Giffoni et al, 2002 while Otranto et al (2007) did not conceal allocation. Otranto et al (2010) did not report sufficient information to judge this.…”

Section: Allocation Concealmentmentioning

confidence: 99%