Prevention of catheter-associated Gram-negative bacilluria with norfloxacin by selective decontamination of the bowel and high urinary concentration

Vollaard, E. J.; Clasener, H. A. L.; Zambon, J; Joosten, H. J. M.; Griethuysen, A. J. A. van

doi:10.1093/jac/23.6.915

Cited by 25 publications

(7 citation statements)

References 13 publications

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“…21 In general, systemic antibiotic drug therapy tends to be most useful in patients requiring urinary catheterization for 3 to 14 days. 21,[68][69][70][71][72][73] Those catheterized for shorter durations are not at high enough risk *Number of patients who developed bacteriuria/total number of participants assigned to each group. †Odds of developing bacteriuria in the silver-coated catheter vs control catheter groups; CI indicates confidence interval.…”

Section: Systemic Antibiotic Drug Therapymentioning

confidence: 99%

Preventing Catheter-Related Bacteriuria

1999

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Up to 25% of hospitalized patients undergo urinary catheterization, and about 5% develop bacteriuria each day of catheterization. Catheter-related bacteriuria is associated with increased morbidity and mortality. We performed an evidence-based synthesis of the literature on preventing catheter-associated urinary tract infections (UTIs) to develop recommendations for clinicians. Catheterization should be avoided when not required and when needed, should be terminated as soon as possible. Use of suprapubic and condom catheters may be associated with a lower risk of UTI than use of urethral catheters. Aseptic catheter insertion and a properly maintained closed drainage system are crucial to reducing the risk of bacteriuria. Instillation of antimicrobial agents into the bladder or urinary drainage bag and rigorous meatal cleansing seem to be of little benefit. Use of urinary catheters coated with silver alloy may reduce the risk of UTI. Systemic antimicrobial drug therapy seems to prevent UTIs, but primarily for patients catheterized for 3 to 14 days. Antibiotic drug prophylaxis is especially valuable in patients undergoing transurethral resection of the prostate or renal transplantation. Using these methods, urinary catheter-associated UTI can often be prevented for weeks, but not longer terms.

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Section: Systemic Antibiotic Drug Therapymentioning

confidence: 99%

Preventing Catheter-Related Bacteriuria

1999

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“…Despite demonstrating a benefit in randomized control trials, especially in patients catheterized for three to 14 days [22,148,172,251,254,259], the use of systemic antibiotic prophylaxis for prevention of CAUTI is not routinely recommended [164,192]. Recovery of resistant organisms in the populations studied was inconsistent.…”

Section: Prophylactic Antibioticsmentioning

confidence: 99%

Hospital-Acquired Infections in the Surgical Intensive Care: Epidemiology and Prevention

2003

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Hospital-acquired infections affect 7% to 10% of hospitalized patients and account for approximately 80,000 deaths per year in the United States. Of all infections acquired in the hospital, more than 20% occur in intensive care unit patients. As the number of ICU beds increases, the proportion of ICU infections is likely to increase. The focus of this paper is to review the epidemiology of hospital-acquired infections that occur in the surgical ICU, particularly ventilator associated pneumonia, catheter-associated urinary tract infection, and catheter-related bloodstream infection, and to discuss ICU-related prevention strategies. By implementing effective preventative measures and maintaining strict surveillance of ICU infections, we hope to affect the associated morbidity, mortality, and cost that our patients and society bare.

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“…In the catheterised patient the prophylactic use of antibiotics reduces the incidence of bacteriuria initially and success has been reported using trimethoprim, sulphamethoxazole or nitrofurantoin; 62 ampicillin; 63 nor¯oxacin 64 and cipro¯oxacin. 65 Studies on the long term e cacy of prophylactic antibiotics have, however, shown no bene®t either in reducing the rate of bacteriuria, 66 or symptoms.…”

Section: Prophylactic Antibioticsmentioning

confidence: 99%

Prevention of urinary tract infection in patients with spinal cord injury – a microbiological review

Galloway

1997

Spinal Cord

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The importance of urinary tract infection (UTI) in patients with spinal cord injury cannot be understated. Many patients with signi®cant bacteriuria are considered to be colonised rather than infected, and treatment should be reserved for those with clinical symptoms or other signs of infection. 1 Published research on the prevention and management of UTI in patients with spinal cord injury often has limitations due to di erences in de®nitions of UTI, studies on groups using di erent urinary drainage appliances, the mixture of newly injured and longstanding injured patients and studies being carried out predominantly on male patients. 2 The complications due to UTI and the di culties in treating established infection mean that prevention is essential. Close urological follow-up is crucial in ensuring that adequate bladder drainage is achieved avoiding the use of long term indwelling urinary catheters if at all possible. 3 For those patients who require long term urinary appliances patient education and strict attention to hygiene and catheter care policies is important. The role of antiseptic/ antibiotics is strictly limited in preventing UTI in patients with spinal cord injury and may even be harmful. Further study into which groups of patients may bene®t from the use of antiseptics or antibiotics is urgently required. Continued research into di erent methods of prevention eg by vaccination, immunotherapy, the use of receptor analogues and bladder interference should also be encouraged.

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Prevention of catheter-associated Gram-negative bacilluria with norfloxacin by selective decontamination of the bowel and high urinary concentration

Cited by 25 publications

References 13 publications

Preventing Catheter-Related Bacteriuria

Preventing Catheter-Related Bacteriuria

Hospital-Acquired Infections in the Surgical Intensive Care: Epidemiology and Prevention

Prevention of urinary tract infection in patients with spinal cord injury – a microbiological review

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