2016
DOI: 10.1126/scitranslmed.aaf9087
|View full text |Cite
|
Sign up to set email alerts
|

Abstract: De novo lipogenesis (DNL), the conversion of glucose and other substrates to lipids, is often associated with ectopic lipid accumulation, metabolic stress, and insulin resistance, especially in the liver. However, organ-specific DNL can also generate distinct lipids with beneficial metabolic bioactivity, prompting a great interest in their use for the treatment of metabolic diseases. Palmitoleate (PAO), one such bioactive lipid, regulates lipid metabolism in liver and improves glucose utilization in skeletal m… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1
1

Citation Types

5
112
1
7

Year Published

2017
2017
2022
2022

Publication Types

Select...
7

Relationship

0
7

Authors

Journals

citations
Cited by 94 publications
(125 citation statements)
references
References 99 publications
5
112
1
7
Order By: Relevance
“…[48] The ability of palmitoleic acid to promote anti-inflammatory effects has been described. [3,4,6,11,14,15,49] In cell cultures, palmitoleic acid was shown to modulate the phenotype of macrophages, reduce expression and production of proinflammatory factors, and block some proinflammatory effects of palmitic acid and LPS [12,14,15,50] (Figure 2). Similarly, supplementation with palmitoleic acid or palmitoleic acid enriched oils reduced inflammation in adipose tissue [26] and liver [4,11] of obese mice fed a high-fat diet.…”
Section: Is Palmitoleic Acid a Plausible Nonpharmacological Strategy mentioning
confidence: 99%
See 3 more Smart Citations
“…[48] The ability of palmitoleic acid to promote anti-inflammatory effects has been described. [3,4,6,11,14,15,49] In cell cultures, palmitoleic acid was shown to modulate the phenotype of macrophages, reduce expression and production of proinflammatory factors, and block some proinflammatory effects of palmitic acid and LPS [12,14,15,50] (Figure 2). Similarly, supplementation with palmitoleic acid or palmitoleic acid enriched oils reduced inflammation in adipose tissue [26] and liver [4,11] of obese mice fed a high-fat diet.…”
Section: Is Palmitoleic Acid a Plausible Nonpharmacological Strategy mentioning
confidence: 99%
“…Gluconeogenesis, glucokinase, SREBP, AMPK, FGF21; required PPARα [14] Primary macrophages from WT, PPARα KO and PPARγ LoxP-LysCre mice incubated with LPS + palmitoleic acid (600 μM), 24 h TNF-α, IL-6 and IL-1β, mRNA for NFκB, IL-1β, TLR4 and HIF-1α, PPARγ , PPARβ; independent of PPARα, PPARγ , and AMPK [12] Mice BMDM or human adipose tissue were consequently increased. [80] In conjunction with increases in palmitoleic acid, the TZDs also improved glycemic control, [80] indicating that palmitoleic acid synthesis could benefit the insulin-sensitizing effect of TZD treatment.…”
Section: Referencementioning
confidence: 99%
See 2 more Smart Citations
“…She has since won grants from both the European Research Council (ERC) and the European Molecular Biology Organization (EMBO), and in the past five months has published papers in both Science Translational Medicine 2 and Proceedings of the National Academy of Sciences 3 on new mechanisms to counter the arteryhardening condition atherosclerosis.…”
Section: Political Upheaval Is Challenging Bold Plans To Become a Leamentioning
confidence: 99%