Prevention and management of knee osteoarthritis and knee cartilage injury in sports

Takeda, Hideki; Nakagawa, Takumi; Nakamura, Kozo; Engebretsen, Lars

doi:10.1136/bjsm.2010.082321

Cited by 80 publications

(55 citation statements)

References 105 publications

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“…The etiology of knee OA is multifactorial. Excessive musculoskeletal loading, high body mass index, previous knee injury, female gender and muscle weakness are well-known risk factors [Takeda et al 2011].…”

Section: Introductionmentioning

confidence: 99%

Efficacy of vitamin E in knee osteoarthritis management of North Indian geriatric population

Bhattacharya¹,

Saxena²,

Gupta³

2011

Therapeutic Advances in Musculoskeletal

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Background: Osteoarthritis (OA) is the most common cause of chronic pain and disability in the elderly. It involves progressive destruction of articular cartilage as a consequence of various factors including augmented oxidative stress with advancing age which has not yet been controlled. It is conceivable that exogenous vitamin E supplementation ameliorates the modifiable indexes via regulation of free radical production and the consumption of antioxidant reserve. The objectives of the present study were to investigate the therapeutic effect of vitamin E supplementation in ameliorating the altered activity of antioxidant enzymes (superoxide dismutase, ceruloplasmin, glutathione peroxidase and catalase), erythrocyte malondialdehyde level (MDA, i.e. marker of lipid peroxidation) and markers of systemic inflammation (plasma C-reactive protein [CRP] and synovial fluid interleukin 6 [IL-6]) in osteoarthritic elderly. Methods: Antioxidant enzymes status, MDA, IL-6 and CRP levels were estimated by using standard methods in 40 healthy individuals (control group) and in 40 osteoarthritic patients aged 50-70 years before and after 3 months of vitamin E supplementation, i.e. group I (nonsupplemented) and group II (200 mg/day vitamin E supplemented). The obtained values were compared statistically by using Student's t-test. Results: Marked alteration in antioxidant enzymes, MDA and inflammatory markers were observed in group I (p < 0.05) as compared with controls. These levels were ameliorated significantly after vitamin E supplementation (p < 0.05) in group II. However, elevated levels of serum CRP and synovial fluid IL-6 (r = 0.034; p < 0.05) were decreased insignificantly (p < 0.1) after vitamin E supplementation in knee OA patients. Conclusions: These findings confirm the protective role of vitamin E supplementation against oxidative stress mediated biomolecular deterioration in OA. However, the anti-inflammatory role of vitamin E remains to be explored.

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Section: Introductionmentioning

confidence: 99%

Efficacy of vitamin E in knee osteoarthritis management of North Indian geriatric population

Bhattacharya¹,

Saxena²,

Gupta³

2011

Therapeutic Advances in Musculoskeletal

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“…14 However, there are also negative consequences. Arthritis from sport-related injury is widely acknowledged, 15 and cognitive impairment from repeated concussion in high-contact sports is an increasing concern. 16 The psychological consequences of retirement are frequently highlighted, although the athlete's professional development in this modern era typically includes planning and preparation for this inevitable event.…”

Section: Long-term Health Outcomes In High-performance Athletesmentioning

confidence: 99%

High-performance sports medicine

Speed

2013

Clinical Medicine

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-High performance sports medicine involves the medical care of athletes, who are extraordinary individuals and who are exposed to intensive physical and psychological stresses during training and competition. The physician has a broad remit and acts as a 'medical guardian' to optimise health while minimising risks. This review describes this interesting field of medicine, its unique challenges and priorities for the physician in delivering best healthcare.

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“…Acute injury and surgery to knee intraarticular tissues and athletic activity that stress the knee joints also lead to an osteoarthritic state (Roos et al, 1998;Takeda et al, 2011). Since there are currently no treatments that slow or reverse the progression of osteoarthritis, current therapeutics focus on managing pain in order to improve function.…”

Section: Introductionmentioning

confidence: 98%

Antinociceptive effect of clinical analgesics in a nonhuman primate model of knee osteoarthritis

Ogawa¹,

Awaga²,

Takashima³

et al. 2016

European Journal of Pharmacology

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Prevention and management of knee osteoarthritis and knee cartilage injury in sports

Abstract: This file was dowloaded from the institutional repository Brage NIH -brage.bibsys.no/nih Takeda, H., Nakagawa, T., Nakamura, K., Engebretsen, L. (2011 and meniscus injury in sports is important to reduce and avoid progression of the knee OA.

Cited by 80 publications

References 105 publications

Efficacy of vitamin E in knee osteoarthritis management of North Indian geriatric population

Efficacy of vitamin E in knee osteoarthritis management of North Indian geriatric population

High-performance sports medicine

Antinociceptive effect of clinical analgesics in a nonhuman primate model of knee osteoarthritis

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