Prevalência e importância clínica dos anticorpos anti-P ribossomal e da proteína S100 beta no lúpus eritematoso sistêmico juvenil

Abstract

Objective: To investigate the prevalence of the anti-ribosomal P (anti-P) antibodies in childhood-onset systemic lupus erythematosus patients (cSLE), healthy controls and first degree relatives. To elucidate the association between anti-P and disease activity, laboratory and treatment features in cSLE patients. Methods: We included consecutive SLE patients with disease onset before 16 years. Controls were age and sex-matched. SLE patients were assessed for clinical and laboratory SLE manifestations, disease activity [SLE Disease Activity Index (SLEDAI)], damage [Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index (SDI)] and current drug exposures. Mood disorders were determined through Becks Depression (BDI) and Becks Anxiety Inventory (BAI). Anti-P measured by enzyme-linked immunosorbent assay. Results: We included 50 consecutive cSLE patients (mean age of 16.82 ± 3.46), 35 first degree relatives (mean age of 38.73 ± 3.89), and 20 health control (mean age of 18.3 ± 4.97). Anti-P was observed in 13 (26%) cSLE patients and in no first-degree relative (p<0.01) or control (p<0.01). Anti-P was more frequently observed in patients with anxiety (p<0.002). No other clinical, laboratory or treatment features, including SLEDAI and SDI scores were associated with the presence of anti-P in cSLE patients. Conclusion: Anti-P is frequently observed in cSLE patients and was associated with the presence of anxiety in this cohort of cSLE.