Prevalência de hepatite C em pacientes com lúpus eritematoso sistêmico do HUCCF-UFRJ

Costa, Cláudia De Abreu; Papi, José Ângelo de Souza; Coelho, Henrique Sérgio De M.; Nogueira, Carmen Martins; Vanderboght, Bart; Soares, Jorge André De S.

doi:10.1590/s0104-42302002000100031

Cited by 3 publications

(2 citation statements)

References 32 publications

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“…16 As the interface of psychic and cognitive symptoms is a frequent and relevant situation in clinical practice, the improvement of neurocognitive symptoms without improvement of depressive symptoms should be highlighted, because the evaluation of these symptoms with integrated tests is important and should be stimulated aiming at improving quality of life during and after HCV infection. 10,17 The average age found is as expected, since it follows the statistical data from Brazil and the world. It speaks in favor of the length of the disease, which is long, and the chronicity of HCV, where patients are submitted to risk factors for depression, which include social stigma and negative expectations about the prognosis.…”

Section: Discussionsupporting

confidence: 83%

“…The high prevalence of depression, both in Brazil and worldwide, in these patients raises questions about characteristics that can be considered risk and protection factors for the development of this disease. 2,4,[10][11][12] Thus, this study aims to describe the frequency of depression in patients with hepatitis C (HCV) and relate it to biological variables and liver function. This work is part of the research project developed in the Hepatology service of HUGG and becomes even more important, since it is an opinion-forming university hospital that intends to benefit patients and the service.…”

Section: Introductionmentioning

confidence: 99%

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High rate of depression in patients with chronic hepatitis C / Taxa elevada de depressão em pacientes com hepatite C crônica

Fakoury

Ximenes

Pires

et al. 2021

RPCF

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Objetivos: descrever a frequência de depressão em pacientes com hepatite C (HCV) e relacionar com as variáveis biológicas e função hepática. Métodos: estudo transversal, descritivo, de abordagem quantitativa, que avaliou a depressão utilizando os critérios do Manual de diagnóstico e estatístico de transtornos mentais (DSM-V) e a associação com as variáveis biológicas e de função hepática em 85 pacientes com HCV crônica indicados para a terapia antiviral de ação direta (DAA) entre maio de 2018 e 2019. Resultados: detectou-se depressão em 47,1% dos pacientes, predominantemente depressão leve (95%). Entretanto a depressão ocorreu de forma independente das características biológicas, como sexo, idade, escolaridade, comorbidades associadas e da função hepática, como grau de fibrose e genótipo viral. Conclusões: a frequência de depressão foi alta em pacientes com HCV e não teve relação estatística com as características biológicas e função hepática, sugerindo a busca ativa da depressão como estratégia na condução destes pacientes.

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Section: Discussionsupporting

confidence: 83%

Section: Introductionmentioning

confidence: 99%

High rate of depression in patients with chronic hepatitis C / Taxa elevada de depressão em pacientes com hepatite C crônica

Fakoury

Ximenes

Pires

et al. 2021

RPCF

View full text Add to dashboard Cite

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Prevalence and impact of chronic hepatitis C virus infection on the clinical manifestations and disease activity among patients suffering from systemic lupus erythematosus

Garf

Shaheen

Gaber

et al. 2013

The Egyptian Rheumatologist

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Aim of the work: To study the prevalence of anti-HCV antibodies among patients suffering from systemic lupus erythematosus (SLE) as well as to determine the impact of chronic HCV infection on the clinical manifestations and disease activity.Patients and methods: Ninety-eight consecutive SLE patients presented to the rheumatology department, Cairo University Hospitals were included in the study. All patients were screened for anti-HCV antibodies using a 3rd generation enzyme-linked immune-sorbent assay (ELISA). Patients with positive anti-HCV were tested for the presence of HCV-RNA by polymerase chain reaction (PCR). Patients were classified into two groups; HCV/SLE and non-HCV/SLE according to the presence or absence of anti-HCV antibodies.Results: Twenty/98 patients (20.4%) were positive for HCV antibody. Eight/98 patients (8.2%) had active viremia. SLE patients with positive anti-HCV antibodies tend to be older in age and having a longer SLE duration than non-HCV/SLE Patients. HCV/SLE patients had significantly lower mucocutaneous manifestations (p < 0.05) and higher cardiac manifestations and fundus abnormalities (p < 0.04, p < 0.01 respectively) than non-HCV/SLE patients. There was no statistical difference between the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) score between both groups. Patients with HCV/SLE were less frequently on oral steroids than patients with non-HCV/SLE. Conclusion: HCV antibodies and active HCV viremia were found in 20.4% and 8.2% respectively among SLE patients. SLE with positive anti-HCV antibodies tend to be older in age and having longer SLE disease duration, lower mucocutaneous and higher cardiac manifestations and fundus abnormalities. Concomitant chronic HCV infection has no adverse impact on SLEDAI.

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Prevalence of hepatitis B virus and hepatitis C virus infection in patients with systemic lupus erythematosus: a systematic review and meta-analysis

Wang

Chen

et al. 2017

Oncotarget

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We attempted to explore the prevalence of HBV and HCV infections in patients with systemic lupus erythematous (SLE) via a systematic review. Articles published before June 2017 and, related to prevalence rates for HBV and HCV infection in SLE patient were identified in PubMed, Embase, CNKI, and Wanfang databases. Based on these searches 22 studies were selected for further analysis. The OR of HBsAg positive rate in SLE patients compared with control population was 0.28, with significant heterogeneity identified among the studies (I2 = 92%, P < 0.00001). Following exclusion of one study, the adjusted OR of HBsAg in patients with SLE was 0.24, and no significant heterogeneity was observed (I2 = 32%, P = 0.15). The adjusted OR of HBcAb positive rate in SLE patients compared with control population was 0.40, with no significant heterogeneity between studies (I2 = 0%, P = 0.56). The risk of having HCV infection by SLE patients was higher compared with the control subjects (OR = 2.91). In conclusion, this meta-analysis suggested that SLE might exert a role of protection against HBV but not for HCV infection. Further epidemiological and experimental studies are necessary to explore the role and mechanisms by which SLE affects HBV/HCV infections.

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Prevalência de hepatite C em pacientes com lúpus eritematoso sistêmico do HUCCF-UFRJ

Cited by 3 publications

References 32 publications

High rate of depression in patients with chronic hepatitis C / Taxa elevada de depressão em pacientes com hepatite C crônica

High rate of depression in patients with chronic hepatitis C / Taxa elevada de depressão em pacientes com hepatite C crônica

Prevalence and impact of chronic hepatitis C virus infection on the clinical manifestations and disease activity among patients suffering from systemic lupus erythematosus

Prevalence of hepatitis B virus and hepatitis C virus infection in patients with systemic lupus erythematosus: a systematic review and meta-analysis

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