Prevalencia de alteraciones del metabolismo hidrocarbonado en una población infanto-juvenil con obesidad grave

Mg, Guijarro De Armas; Megías, Susana Monereo; S, Civantos Modino; Martínez, July Maribel Montaño; Bolaños, Paloma Iglesias; M, Durán Martínez

doi:10.1016/j.endonu.2010.09.002

Cited by 9 publications

(1 citation statement)

References 11 publications

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“…2A and B black traces and see also the histogram D). Previous manuscripts reported an elevated predisposition within the obese population for suffering DM2 [26][27][28][29][30][31], which agree with the fact that most of the patients selected for this study were also overweight (50% of analysed patients have a BMI over 30), and in addition, STC2 -/mice are oversize and overweight [32], as it was corroborated in our colonies (reporting a weight of 20.0 AE 1.9 gr and 26.7 AE 1.72 gr in WT and STC2 -/-, respectively, at the 10 weeks of age; n = 15-20; meanwhile at the age of 40 weeks, no differences in weight were observed). Hence, we suggested whether STC2 -/mice would be a good model for describing the molecular events contributing with the appearance of DM2 in obese patients.…”

Section: Glycaemia In Wt and Stc2 -/Micementioning

confidence: 99%

Involvement of stanniocalcins in the deregulation of glycaemia in obese mice and type 2 diabetic patients

López

Jardín

Chamorro

et al. 2017

J Cellular Molecular Medi

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Stanniocalcins are expressed in the pancreas tissue, and it was suggested a direct correlation between circulating insulin and STC2 concentrations in human. Here, we show a significant correlation between STC1 and both glycaemia and glycosylated haemoglobin among DM2 patients, while DM2 patients who present the greatest glycosylated haemoglobin values exhibited the lowest STC2 expression. However, treatment of patients with antiglycaemic drugs does not significantly modify the expression of both STCs. On the other hand, STC2‐/‐ mice that exhibited neonatal and adult overweight further presented deregulated glycaemia when they were feed with a hypercaloric diet (breeding pellet, BP). This alteration is more evident at the early stages of the animal life. Deregulated glycaemia in these mice was confirmed using glucose oral test. In addition, STC2‐/‐ mice present enhanced pancreas size; thus, the histological analysis reveals that WT mice respond to BP diet by increasing the size of the pancreatic islets through inducing cell division, and STC2‐/‐ mice lack this compensatory mechanism. Contrary, BP fed STC2‐/‐ mice show enhanced number of islets but of similar size than those fed with regular pellet. Histopathological analysis demonstrates tissue structure disruption and erythrocytes infiltrations in STC2‐/‐ mice, possibly due to the stress evoked by the BP diet. Finally, enhanced glucagon immunostaining was observed in the islet of STC2‐/‐ mice, and the glucagon ELISA assay confirmed the increase in the circulating glucagon. Summarizing, we present evidence of the role of STCs, mainly STC2, as a possible early marker during development of diabetes mellitus.

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Section: Glycaemia In Wt and Stc2 -/Micementioning

confidence: 99%

Involvement of stanniocalcins in the deregulation of glycaemia in obese mice and type 2 diabetic patients

López

Jardín

Chamorro

et al. 2017

J Cellular Molecular Medi

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Prevalence of insulin resistance and impaired glucose tolerance in a sample of obese spanish children and adolescents

et al. 2011

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The prevalence of obesity in children has increased in developed countries in the last decades. It is associated with alterations in glucose metabolism that may be present in childhood. To assess the frequency of glucose metabolism alterations and insulin resistance and their possible determinants in a sample of obese children from Valladolid (Spain), we retrospectively studied 100 obese children and adolescents (11.59 ± 2.73 years). Anthropometric measures, biochemical parameters, and oral glucose tolerance test (OGTT) were performed. Insulin resistance was evaluated with fasting insulin, HOMA index, and insulin values in OGTT. Impaired glucose tolerance was found in 15% of the sample, and was the most frequent of glucose metabolism alterations. Impaired fasting glucose was found in 2%. No case of type 2 diabetes was found. Acanthosis nigricans was present in 22%, with predominance in females, but not all presented insulin resistance. The prevalence of insulin resistance was 29% when HOMA index was used, and 50% when the insulin response in OGTT was used. Not all patients with impaired glucose tolerance had a pathological HOMA index, and not all with pathological HOMA index presented insulin resistance when insulin values in OGTT were used. Higher 2-h post-OGTT insulin levels were found in children with impaired glucose tolerance. It is paramount to identify young people with glucose regulation alterations for early, intensive intervention to prevent or at least postpone the onset of type 2 diabetes. OGTT is a screening tool necessary to fulfill this objective.

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Diabetes mellitus tipo 2 en adolescentes en una unidad de diabetes pediátrica

Quispe

Martín

Frías

et al. 2015

Anales de Pediatría

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Prevalencia de alteraciones del metabolismo hidrocarbonado en una población infanto-juvenil con obesidad grave

Cited by 9 publications

References 11 publications

Involvement of stanniocalcins in the deregulation of glycaemia in obese mice and type 2 diabetic patients

Involvement of stanniocalcins in the deregulation of glycaemia in obese mice and type 2 diabetic patients

Prevalence of insulin resistance and impaired glucose tolerance in a sample of obese spanish children and adolescents

Diabetes mellitus tipo 2 en adolescentes en una unidad de diabetes pediátrica

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