Prevalence, risk factors and genetic traits of Salmonella Infantis in Dutch broiler flocks

Mughini‐Gras, Lapo; Hoek, Angela H.A.M. van; Cuperus, Tryntsje; Dam-Deisz, Cecile; Overbeek, W. van; Beld, Maaike van den; Wit, Ben; Rapallini, Michel; Wullings, Bart; Franz, Eelco; Giessen, Joke van der; Dierikx, Cindy; Opsteegh, Marieke

doi:10.1016/j.vetmic.2021.109120

Cited by 28 publications

(34 citation statements)

References 20 publications

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“…In particular, in 2020, S. Muenchen was responsible for a single strong-evidence outbreak, in Germany, due to contamination of 'coconut pieces or coconut flakes' (further details are provided in the foodborne outbreak chapter). S. Dublin cases in humans are frequently associated with invasive disease and systemic illness related to the presence of several virulence factors which could be responsible for a greater likelihood of investigation and detection (Mohammed et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

The European Union One Health 2020 Zoonoses Report

2021

EFS2

351

314

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This report of the EFSA and the European Centre for Disease Prevention and Control presents the results of zoonoses monitoring activities carried out in 2020 in 27 EU Member States (MS) and nine non-MS. Key statistics on zoonoses and zoonotic agents in humans, food, animals and feed are provided and interpreted historically. Two events impacted 2020 MS data collection and related statistics: the Coronavirus Disease 2019 (COVID-19) pandemic and the withdrawal of the United Kingdom from the EU. In 2020, the first and second most reported zoonoses in humans were campylobacteriosis and salmonellosis, respectively. The EU trend for confirmed human cases of these two diseases was stable (flat) from 2016 to 2020. Fourteen of the 26 MS reporting data on Salmonella control programmes in poultry met the reduction targets for all poultry categories. Salmonella results for carcases of various species performed by competent authorities were more frequently positive than own-checks conducted by food business operators. This was also the case for Campylobacter quantification results from broiler carcases for the MS group that submitted data from both samplers, whereas overall at EU level, those percentages were comparable. Yersiniosis was the third most reported zoonosis in humans, with 10-fold less cases reported than salmonellosis, followed by Shiga toxin-producing Escherichia coli (STEC) and Listeria monocytogenes infections. Illnesses caused by L. monocytogenes and West Nile virus infections were the most severe zoonotic diseases with the highest case fatality. In 2020, 27 MS reported 3,086 foodborne outbreaks (a 47.0% decrease from 2019) and 20,017 human cases (a 61.3% decrease). Salmonella remained the most frequently reported causative agent for foodborne outbreaks. Salmonella in 'eggs and egg products', norovirus in 'crustaceans, shellfish, molluscs and products containing them' and L. monocytogenes in 'fish and fish products' were the agent/food pairs of most concern. This report also provides updates on tuberculosis due to Mycobacterium bovis or Mycobacterium caprae, Brucella, Trichinella, Echinococcus, Toxoplasma, rabies, Coxiella burnetii (Q fever) and tularaemia.

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Section: Discussionmentioning

confidence: 99%

The European Union One Health 2020 Zoonoses Report

2021

EFS2

351

314

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“…More recently, the emergence of MDR S. Infantis was reported in many regions of the world including Israel [8], Europe [9][10][11][12][13], UK [14], Russia [15], South America [16][17][18], and USA [19].…”

Section: Introductionmentioning

confidence: 99%

“…This conjugative plasmid was first identified and characterized in an emerging S. Infantis clone in Israel and was shown to encode genes providing resistance to tetracycline, sulphonamides, and trimethoprim, and additional virulence factors that could enhance pathogenicity phenotypes and stress tolerance [8,20,21]. Later, conserved pESIlike plasmids were also found in emerging S. Infantis lineages worldwide [10,11,13,[15][16][17][18]. These pESI-related plasmids share the same backbone as pESI, but may carry varying antibiotic resistant J o u r n a l P r e -p r o o f cassettes including extended-spectrum β-lactamase (ESBL) genes [9,11,14,19,22].…”

Section: Introductionmentioning

confidence: 99%

The emergence of a multidrug resistant Salmonella Muenchen in Israel is associated with horizontal acquisition of the epidemic pESI plasmid

Cohen

Kriger

Amit

et al. 2022

Clinical Microbiology and Infection

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“…This has prompted the World Health Organization (WHO) to place the ESBL-producing Enterobacteriaceae on the list of “Critical Priority Pathogens” that pose a great risk to public health ( World Health Organization [WHO], 2019 ). MDR strains of S. Infantis isolated in broilers have been now recorded in multiple countries, including Hungary ( Szmolka et al, 2018 ), Germany ( García-Soto et al, 2020 ), Italy ( Alba et al, 2020 ; Proietti et al, 2020 ), the Netherlands ( Mughini-Gras et al, 2021 ), Russia ( Bogomazova et al, 2020 ), and United States ( Tate et al, 2017 ). A recent study showed that global population of S. Infantis could be divided into three major lineages ( Gymoese et al, 2019 ).…”

Section: Introductionmentioning

confidence: 99%

The Current Landscape of Antibiotic Resistance of Salmonella Infantis in Italy: The Expansion of Extended-Spectrum Beta-Lactamase Producers on a Local Scale

et al. 2022

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Salmonella enterica serovar Infantis is one of the five main causes of human salmonellosis in the European Union (EU) and in recent years, has been increasingly reported to carry multiple antimicrobial resistance determinants, including extended-spectrum beta-lactamase (ESBL) genes. In our study, we used WGS-based tools to characterize S. Infantis strains circulating in the Abruzzo and Molise regions of Italy between 2017 and 2020 and compared this local dataset to the S. Infantis population present in Italy over the last two decades. Phylogenetic analyses demonstrated that the majority of strains isolated from poultry and turkeys from Abruzzo and Molise were closely related and belonged to one of the two main genetic clusters present in Italy, which were grouped predominantly as ESBL-producing strains that harbored pESI-like plasmid. We showed that 60% of the local strains carried multiple antibiotic resistance genes, including ESBL gene blaCTX–M–1 as well as aadA1, dfrA1, dfrA14, sul1, and tet(A) genes present on the pESI-like megaplasmid. The analysis of strains from Abruzzo and Molise and the publicly available Italian S. Infantis sequences revealed a dramatic increase in the number of identified AMR genes in the strains isolated after 2011. Moreover, the number of strains resistant to five or more antibiotic classes increased from 20–80% in the last decade likely due to the acquisition of the megaplasmid. The persistence of the ESBL-producing and the multidrug-resistant (MDR) clone of S. Infantis in poultry populations in Italy and in Europe requires rapid and efficient intervention strategies to prevent further expansion of the clone.

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Prevalence, risk factors and genetic traits of Salmonella Infantis in Dutch broiler flocks

Cited by 28 publications

References 20 publications

The European Union One Health 2020 Zoonoses Report

The European Union One Health 2020 Zoonoses Report

The emergence of a multidrug resistant Salmonella Muenchen in Israel is associated with horizontal acquisition of the epidemic pESI plasmid

The Current Landscape of Antibiotic Resistance of Salmonella Infantis in Italy: The Expansion of Extended-Spectrum Beta-Lactamase Producers on a Local Scale

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