Prevalence of vernal keratoconjunctivitis: a rare disease?

Bremond-Gignac, Dominique; Donadieu, Jean; Leonardi, Andrea; Pouliquen, P; Doan, Serge; Chiambarretta, F; Montan, Per; Milazzo, S.; Hoang–Xuan, T.; Baudouin, Christophe; Aymé, Ségolène

doi:10.1136/bjo.2007.117812

Cited by 105 publications

(78 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It is unusual in most of North America and Western Europe. 19 A study conducted in school children of Karachi by Baig R et al in 2010 showed a prevalence of allergic conjunctivitis of 19.2 % which is close to the findings of this study (20.9%).…”

supporting

confidence: 89%

A cross-sectional study to assess the morbidity pattern of ocular diseases in out-patient department of ophthalmology at a tertiary care hospital

Mohanty¹,

Banu

2016

Int J Res Med Sci

View full text Add to dashboard Cite

supporting

confidence: 89%

A cross-sectional study to assess the morbidity pattern of ocular diseases in out-patient department of ophthalmology at a tertiary care hospital

Mohanty¹,

Banu

2016

Int J Res Med Sci

View full text Add to dashboard Cite

“…However, it is not unusual to see occasional vernal conjunctivitis patients throughout the United States and Canada. The prevalence of VKC in Europe ranges from 1.2 to 10.6 cases per 10,000 population, although the prevalence of associated corneal complications is much lower (0.3-2.3 per 10,000 population) [15]. Young people are typically affected [16].…”

Section: Allergic Conjunctivitismentioning

confidence: 99%

Allergic conjunctivitis: a comprehensive review of the literature

et al. 2013

View full text Add to dashboard Cite

Ocular allergy represents one of the most common conditions encountered by allergists and ophthalmologists. Allergic conjunctivitis is often underdiagnosed and consequently undertreated. Basic and clinical research has provided a better understanding of the cells, mediators, and immunologic events, which occur in ocular allergy. New pharmacological agents have improved the efficacy and safety of ocular allergy treatment. An understanding of the immunologic mechanisms, clinical features, differential diagnosis, and treatment of ocular allergy may be useful to all specialists who deal with these patients. The purpose of this review is to systematically review literature underlining all the forms classified as ocular allergy: seasonal allergic conjunctivitis, perennial allergic conjunctivitis, vernal keratoconjunctivitis, atopic keratocongiuntivitis, contact allergy, and giant papillary conjunctivitis.

show abstract

“…The prevalence of VKC varies greatly and increases with vicinity to the equator. In Scandinavian countries, prevalence is close to 0%, whereas it reaches 0.27% in Italy and is higher still in Africa, with a reported prevalence of 6% in Ethiopia . Although the causes of VKC are still unclear, there is a strong correlation with exposure to sunlight, which exacerbates the disease …”

Section: Introductionmentioning

confidence: 99%

Role of ocular cytology in vernal keratoconjunctivitis

Bruschi

Ghiglioni

Osnaghi

et al. 2019

Immunity Inflam & Disease

View full text Add to dashboard Cite

Background Children with vernal keratoconjunctivitis (VKC) present symptoms that are similar to other ocular allergies, but more pronounced, and are controlled using topical steroids. To avoid excessive and prolonged use of topical steroid eye drops, over the past 20 years galenic eye drops of cyclosporine with a concentration of 1% to 2% and tacrolimus with a concentration of 0.1% have been introduced as a treatment for the severe and unresponsive forms. The main symptoms of VKC occur most frequently during the spring and tend to get worse during the summer, meaning that affected children tend to avoid exposure to sunlight. The aim of this study was to assess the most common cell types present in the conjunctiva of children with VKC, how ocular treatment can influence them, and whether affected children express a typical conjunctival pattern, which could be useful as a pathognomonic pattern of VKC, allowing us to study this rare eye disease. Method This was a cohort study of 56 children, of whom 17 were not receiving any treatment at the time of testing, 14 were using steroid eye drops or had taken them in the previous 10 days, and 25 were treated with cyclosporine eye drops or tacrolimus eye drops 0.1%. Result Children in group 1 (no topical therapy) express more epithelial cells, neutrophils, mast cells, eosinophils, and lymphocytes than the other two groups. Conclusion Given the ease of performance, when conducting further longitudinal studies, the conjunctival cytology examination could be used, on the one hand, to diagnose VKC, especially when the clinical diagnosis is uncertain, and, on the other, to follow disease evolution and monitor the response to topical treatment.

show abstract

Prevalence of vernal keratoconjunctivitis: a rare disease?

Abstract: Based on the most likely hypotheses concerning disease duration and non-responding ophthalmologists' VKC case rate, the best estimate of VKC prevalence in Western Europe is 3.2/10,000 inhabitants. The prevalence of VKC with corneal complications is 0.8/10,000 inhabitants.

Cited by 105 publications

References 25 publications

A cross-sectional study to assess the morbidity pattern of ocular diseases in out-patient department of ophthalmology at a tertiary care hospital

A cross-sectional study to assess the morbidity pattern of ocular diseases in out-patient department of ophthalmology at a tertiary care hospital

Allergic conjunctivitis: a comprehensive review of the literature

Role of ocular cytology in vernal keratoconjunctivitis

Contact Info

Product

Resources

About