Prevalence of undiagnosed diabetes and pre-diabetes in chronic periodontitis patients assessed by an HbA1c chairside screening protocol

Mataftsi, Maria; Koukos, George; Sakellari, Dimitra

doi:10.1007/s00784-019-02888-y

Cited by 17 publications

(21 citation statements)

References 27 publications

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“…Another recent Greek study examined chairside HbA1c testing of patients with (mostly mild) chronic periodontitis and found that 25% of patients had unknown hyperglycemia. 7 This rate is higher than the current study, but the examination included >80% obese individuals and showed that BMI and waist circumference were associated with HbA1c. 7 In general, all available results confirm the benefit of DM screening in a dental practice setting.…”

Section: Comparison To the Existing Literaturecontrasting

confidence: 64%

“…7 This rate is higher than the current study, but the examination included >80% obese individuals and showed that BMI and waist circumference were associated with HbA1c. 7 In general, all available results confirm the benefit of DM screening in a dental practice setting. Therefore, blood testing in dental settings may have a higher sensitivity because a statement on the patient's hyperglycemia is independent of patient compliance (straightforward answering, visiting the general physician).…”

Section: Comparison To the Existing Literaturecontrasting

confidence: 64%

“…8 One available study that investigated patients with moderate periodontitis found no relationship between DM and periodontal parameters. 7 However, examining periodontally diseased individuals seems reasonable. A study from a university clinic setting found a two-fold higher amount of suspected new DM in patients with severe compared with mild/moderate periodontitis.…”

Section: Comparison To the Existing Literaturementioning

confidence: 99%

“…6 Therefore, the concept of screening for unknown DM in patients suffering from periodontal diseases in dental practice was repeatedly mentioned. [7][8][9][10][11][12][13][14][15][16] In general, DM screening in dental settings is a promising approach to detect previously unknown (pre-)DM. Two different procedures are available: invasive blood collection in the dental office for HbA1c measurement 7,15,[17][18][19] and a non-invasive questionnairebased screening followed by the allocation of at-risk patients to general physicians/diabetologists.…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of a questionnaire‐based diabetes screening concept in German patients with Stage III or IV periodontitis: A practice‐based study

Schmalz

Wolf

Merle

et al. 2020

Journal of Periodontology

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Background: This practice-based retrospective study evaluated a screening method for diabetes mellitus (DM) in patients with Stage 3 or 4 periodontitis using the FINDRISC questionnaire. Methods: Patients with Stage 3 or 4 periodontitis who received FINDRISC screening in a German private dental practice were recruited. Individuals with positive FINDRISC scores (≥12, FINDRISC+) were referred for diabetological examination. Several general and periodontal findings from the patients' documentation were recorded and analyzed. Results: A total of 179 patients (52.65 ± 11.49 years) were included. In DM screening, 24.6% (n = 44) patients were FINDRISC+, including all patients with currently known DM (21 of 21). Of the remaining FINDRISC+ patients, 82.6% (19 of 23) visited their general practitioner, and 63.2% (12 of 19, 7.6% of total cohort) had an HbA1c ≥5.7%. Accordingly, 75% of the FINDRISC+ patients were diabetologically conspicuous (HbA1c ≥ 5.7%), including those with already known DM. Patients with previously unknown DM showed higher mean age, more missing teeth, a higher periodontitis stage (more Stage 4) and more frequently teeth with suppuration compared with the diabetologically inconspicuous individuals (P <0.01). Conclusion: The FINDRISC questionnaire is appropriate for patients with Stage 3 or 4 periodontitis and can be recommended in dental practice setting.

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Section: Comparison To the Existing Literaturecontrasting

confidence: 64%

Section: Comparison To the Existing Literaturecontrasting

confidence: 64%

Section: Comparison To the Existing Literaturementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Evaluation of a questionnaire‐based diabetes screening concept in German patients with Stage III or IV periodontitis: A practice‐based study

Schmalz

Wolf

Merle

et al. 2020

Journal of Periodontology

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“…These conditions are known to upregulate aMMP-8 in inflamed gingiva and oral fluids [5,6]. It has been suggested that screening for prediabetes/diabetes is feasible at dental clinics especially for patients with periodontal disease [7][8][9][10][11]. Therefore, it would be practical and economical to link chair-side/point-of-care (PoC) testing to the diagnostic examination for periodontitis and screening for prediabetes/diabetes at the dentist's office, since it has been shown that patients meet oral health care professionals on a more regular basis compared to their visits to a physician [12].…”

Section: Introductionmentioning

confidence: 99%

Prediabetes/Diabetes Can Be Screened at the Dental Office by a Low-Cost and Fast Chair-Side/Point-of-Care aMMP-8 Immunotest

et al. 2019

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Pre-diabetes and diabetes are strongly associated with periodontal disease (gingivitis and periodontitis), and these conditions are known to upregulate aMMP-8 in inflamed gingiva and oral fluids. Thus, it would be feasible to screen for prediabetes and diabetes at the dental office by chairside tests. Chair-side assessment of HbA1c and a quantitative point-of-care (PoC) active matrix metalloproteinase (aMMP)-8 oral rinse immunotest developed for periodontal diseases, were performed on patients (n = 69) attending a Periodontology University Clinic who fulfilled the criteria for testing according to the screening questionnaire of the Centers for Disease Control and Prevention, USA. Clinical parameters of periodontal disease were also recorded with an automated probe. Twenty seven-point-five percent of the subjects were found with previously unknown hyperglycemia (HbA1c ≥ 5.7%). There was a statistically-significant positive association between the aMMP-8test and prediabetes (p < 0.05, unadjusted and adjusted for BMI and age ≥ 45 years logistic regression models). The dental setting is suitable for opportunistic screening for undiagnosed diabetes and pre-diabetes and point-of-care HbA1c, especially when combined with aMMP-8 assessment by dental professionals, being convenient and effective.

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Disorders of the Endocrine System and of Metabolism

Schifter¹,

McLean²,

Sukumar³

2021

Burket's Oral Medicine

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Prevalence of undiagnosed diabetes and pre-diabetes in chronic periodontitis patients assessed by an HbA1c chairside screening protocol

Cited by 17 publications

References 27 publications

Evaluation of a questionnaire‐based diabetes screening concept in German patients with Stage III or IV periodontitis: A practice‐based study

Evaluation of a questionnaire‐based diabetes screening concept in German patients with Stage III or IV periodontitis: A practice‐based study

Prediabetes/Diabetes Can Be Screened at the Dental Office by a Low-Cost and Fast Chair-Side/Point-of-Care aMMP-8 Immunotest

Disorders of the Endocrine System and of Metabolism

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