Prevalence of Taste Changes and Association with Other Nutrition-Related Symptoms in End-Stage Kidney Disease Patients

Dawson, Joseph; Brennan, Frank; Hoffman, Anna; Josland, Elizabeth; Li, Kelly; Smyth, Alison; Brown, Mark

doi:10.1053/j.jrn.2020.06.003

Cited by 21 publications

(27 citation statements)

References 23 publications

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“…Many CKD patients are elderly and using multiple medications that can affect taste sensations and increase zinc deficiency [ 38 ]. Taste change has been reported by 40–60% of pre-dialysis CKD [ 57 ] and hemodialysis [ 58 , 59 ] patients, with taste changes of “bland” and “bitter” found to be associated with upper gastrointestinal symptoms, including nausea, vomiting, anorexia, and malnutrition [ 59 ].…”

Section: Zinc Deficiency In Ckdmentioning

confidence: 99%

Association of Zinc Deficiency with Development of CVD Events in Patients with CKD

et al. 2021

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Deficiency of the micronutrient zinc is common in patients with chronic kidney disease (CKD). The aim of this review is to summarize evidence presented in literature for consolidation of current knowledge regarding zinc status in CKD patients, including those undergoing hemodialysis. Zinc deficiency is known to be associated with various risk factors for cardiovascular disease (CVD), such as increased blood pressure, dyslipidemia, type 2 diabetes mellitus, inflammation, and oxidative stress. Zinc may protect against phosphate-induced arterial calcification by suppressing activation of nuclear factor kappa light chain enhancer of activated B. Serum zinc levels have been shown to be positively correlated with T50 (shorter T50 indicates higher calcification propensity) in patients with type 2 diabetes mellitus as well as those with CKD. Additionally, higher intake of dietary zinc was associated with a lower risk of severe abdominal aortic calcification. In hemodialysis patients, the beneficial effects of zinc supplementation in relation to serum zinc and oxidative stress levels was demonstrated in a meta-analysis of 15 randomized controlled trials. Thus, evidence presented supports important roles of zinc regarding antioxidative stress and suppression of calcification and indicates that zinc intake/supplementation may help to ameliorate CVD risk factors in CKD patients.

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Section: Zinc Deficiency In Ckdmentioning

confidence: 99%

Association of Zinc Deficiency with Development of CVD Events in Patients with CKD

et al. 2021

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“…First, serum zinc levels have been associated with fluid volume and nutritional status in HD patients [ 33 ]. Taste changes are common and associated with malnutrition in maintenance dialysis patients [ 34 ], and they may result in decreased intake of calories and zinc-rich foods. Second, lower serum zinc has been associated with intradialytic hypertension in HD patients [ 35 ].…”

Section: Discussionmentioning

confidence: 99%

Association between Reduced Serum Zinc and Diastolic Dysfunction in Maintenance Hemodialysis Patients

Huang

et al. 2021

Nutrients

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Diastolic dysfunction is an emerging challenge among hemodialysis (HD) patients, and the associations between serum zinc with echocardiographic parameters and diastolic function remain uncertain. A total of 185 maintenance HD patients were stratified by the tertiles of serum zinc level to compare their clinical characteristics and echocardiography. Correlations of serum zinc levels with echocardiographic parameters were examined using Pearson’s analysis. Univariate and multivariate logistic regression analyses were performed to investigate the determinants of E/e’ ratio >15 and left atrial volume index (LAVI) > 34 mL/m2, both indicators of diastolic dysfunction. Patients belonging to the first tertile of serum zinc level had a significantly higher E/e’ ratio and LAVI. Serum zinc levels were negatively correlated with E (r = −0.204, p = 0.005), E/e’ ratio (r = −0.217, p = 0.003), and LAVI (r = −0.197, p = 0.007). In a multivariate analysis, older age, diabetes, coronary artery disease, and lower serum zinc levels (OR = 0.974, 95% CI = 0.950–0.999, p = 0.039) were significantly associated with E/e’ ratio >15. Furthermore, diabetes and lower serum zinc levels (OR = 0.978, 95% CI = 0.958–0.999, p = 0.041) were significantly associated with LAVI >34 mL/m2. Reduced serum zinc level was significantly associated with diastolic dysfunction among HD patients. Further prospective studies are warranted to investigate whether zinc supplementation can attenuate cardiac dysfunction in maintenance HD patients.

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“…We suggest that health professionals working with these patients refer to important guidance published to assist with diet and symptom management. [30][31][32] To conclude this commentary, the KDOQI nutrition guidelines represent an important discussion of nutrient based guidance as well as food-based recommendations. While input from consumers into these guidelines is lacking, these guidelines are an important step forward and may reduce the challenge and complexity for patients of adhering to the diet for kidney disease.…”

Section: Future Directions and Conclusionmentioning

confidence: 99%

“…There is a notable absence of information for clinicians on the dietary management of patients undertaking conservative management (also referred to as supportive care 29 ). We suggest that health professionals working with these patients refer to important guidance published to assist with diet and symptom management 30–32 …”

Section: Future Directions and Conclusionmentioning

confidence: 99%

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Commentary on the 2020 update of the KDOQI clinical practice guideline for nutrition in chronic kidney disease

et al. 2022

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Dietary modification is an important component in the management of Chronic Kidney Disease (CKD). 1 An appropriate diet can slow disease progression, 2,3 reduce CKD complications, 4 and increase survival. 5,6 The release of new guidance has been eagerly awaited by many clinicians as the previous versions had not been updated since 2000. 7 The intent of this commentary is to consider some of the key recommendations in the Australian and New Zealand context and to highlight areas for potential local adaptation.

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Prevalence of Taste Changes and Association with Other Nutrition-Related Symptoms in End-Stage Kidney Disease Patients

Cited by 21 publications

References 23 publications

Association of Zinc Deficiency with Development of CVD Events in Patients with CKD

Association of Zinc Deficiency with Development of CVD Events in Patients with CKD

Association between Reduced Serum Zinc and Diastolic Dysfunction in Maintenance Hemodialysis Patients

Commentary on the 2020 update of the KDOQI clinical practice guideline for nutrition in chronic kidney disease

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