Prevalence of restless legs syndrome in patients with irritable bowel syndrome

Basu, Patrick; Shah, Niel; Krishnaswamy, Nithya; Pacana, Tommy

doi:10.3748/wjg.v17.i39.4404

Cited by 17 publications

(11 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our findings of IBS patients with co-morbid RLS revealed they suffered more from stomach pain, nausea and vomiting. Although, not statistically significant, the highest prevalence of RLS was reported in IBS-M (28.1%) and IBS-C (26.7%) patients, respectively, which was not in line with Basu's report 21. Even though SIBO is not evaluated in our study, this difference between Basu's findings21 and our investigation may reflect different portion of SIBO subtypes such as hydrogen-producer or methane-producer; where methane-producer has been reported to be more associated with constipation 22…”

Section: Discussioncontrasting

confidence: 75%

Association Between Irritable Bowel Syndrome and Restless Legs Syndrome: A Comparative Study With Control Group

Borji¹,

Fereshtehnejad²,

Vakili³

et al. 2012

J Neurogastroenterol Motil

View full text Add to dashboard Cite

Background/AimsAs a common gastrointestinal (GI) disorder, irritable bowel syndrome (IBS) has been reported to be associated with some psychological and neurological factors. This study aimed to evaluate the prevalence rate of restless legs syndrome (RLS) in a sample of IBS patients and to compare this prevalence with that of matched healthy controls.MethodsThis prospective comparative study was conducted in Tehran, Iran during 2010-2011. Based on the Rome III criteria, a total number of 225 definite IBS patients and 262 age- and sex-matched healthy controls were recruited in the final assessment to compare the prevalence rate of RLS between the 2 groups.ResultsRLS was significantly more frequent in IBS group (25.3% vs 6.5%, P < 0.001) which led to an odds ratio (OR) of 4.89 (95% CI, 2.75-8.70). IBS patients with co-morbid RLS significantly suffered more from stomach pain (96.5% vs 86.3%, OR = 4.36 [95% CI, 1.00-19.12]), nausea (40.4% vs 21.4%, OR = 2.48 [95% CI, 1.30-4.73]) and vomiting (10.5% vs 2.4%, OR = 4.82 [95% CI, 1.31-17.76]).ConclusionsBy enrolling a considerable number of IBS patients and healthy controls, our study showed a significantly higher prevalence of RLS in IBS patients. Surprisingly, a higher prevalence rate of RLS was also accompanied with a more severe discomfort and stomach pain in IBS patients. It seems that screening patients with IBS for RLS may lead to greater identification of RLS and improved treatment for both conditions.

show abstract

Section: Discussioncontrasting

confidence: 75%

Association Between Irritable Bowel Syndrome and Restless Legs Syndrome: A Comparative Study With Control Group

Borji¹,

Fereshtehnejad²,

Vakili³

et al. 2012

J Neurogastroenterol Motil

View full text Add to dashboard Cite

show abstract

“…Such a sensorimotor disorder is called restless legs syndrome and it affects from 1 to 10 percent of the population [21]. Interestingly, it was found that restless legs syndrome prevails in patients with intestinal disorders [22].…”

Section: The Visceral Theory Of Sleepmentioning

confidence: 99%

Visceral theory of sleep and origins of mental disorders

2018

View full text Add to dashboard Cite

show abstract

“…Moreover, changes in the small intestinal bacterial overgrowth (SIBO)-related inflammatory mediator impaired communication between enteric and central nervous system are reported as the pathogenetic mechanisms [5]. A couple of studies have suggested that sleep disorders, particularly restless legs syndrome (RLS), are possible comorbidities in IBS patients [6, 7]. According to the previous studies, nearly 25%–30% of IBS patients experience RLS [6–8].…”

Section: Introductionmentioning

confidence: 99%

Use of antidepressants and risks of restless legs syndrome in patients with irritable bowel syndrome: A population-based cohort study

et al. 2019

View full text Add to dashboard Cite

Previous research has suggested an association between antidepressants use and clinical restless legs syndrome (RLS) in patients, but there has never been a single study investigating the risk of RLS in irritable bowel syndrome (IBS) patients treated with antidepressants. Hence, we aimed to explore the association between IBS and RLS and to examine the risk of RLS in IBS patients treated with antidepressants. With the use of the National Health Insurance Research Database of Taiwan, 27,437 adults aged ≥ 20 years with newly diagnosed IBS (ICD-9-CM Code 564.1) and gender- and age-matched 54,874 controls without IBS were enrolled between 2000 and 2012. All patients were followed-up until RLS diagnosis, withdrawal from the National Health Insurance program, or end of 2013. We used the Cox proportional hazards model to calculate the hazard ratios (HRs) and 95% confidence intervals (CIs) of RLS. RLS was more prevalent in IBS patients than in the non-IBS group (7.57 versus 3.36 per 10,000 person-years), with an increased risk of RLS (adjusted HR [aHR], 1.91; 95% CI, 1.52–2.40). Multivariate Cox proportional hazards analysis identified older age (age, 51–65 years; aHR, 1.67; 95% CI, 1.09–2.56; and age > 65; aHR, 1.59; 95% CI, 1.02–2.48), hypothyroidism (aHR, 4.24; 95% CI, 1.92–9.37), CAD (aHR, 1.70; 95% CI, 1.17–2.48), and depression (aHR, 3.15; 95% CI, 2.14–4.64) as independent RLS risk factors in IBS patients. In addition, the male SSRIs users were associated with significantly higher risk of RLS (aHR, 3.05 95% CI, 1.34–6.92). Our study showed that the IBS group has higher risk of RLS. Moreover, SSRIs use may increase the risk of RLS in male IBS patients.

show abstract

Prevalence of restless legs syndrome in patients with irritable bowel syndrome

Abstract: Restless legs syndrome is prevalent in patients with IBS, especially those with diarrheal symptoms. Assessment of concomitant disorders may improve diagnosis and expand relevant treatment options for patients.

Cited by 17 publications

References 25 publications

Association Between Irritable Bowel Syndrome and Restless Legs Syndrome: A Comparative Study With Control Group

Association Between Irritable Bowel Syndrome and Restless Legs Syndrome: A Comparative Study With Control Group

Visceral theory of sleep and origins of mental disorders

Use of antidepressants and risks of restless legs syndrome in patients with irritable bowel syndrome: A population-based cohort study

Contact Info

Product

Resources

About