Prevalence of Postpartum Endometritis and Antimicrobial Resistance of Responsible Pathogens in Ukraine: Results a Multicenter Study (2015-2017)

Salmanov, Aidyn G; Vitiuk, Alla D; Zhelezov, D. M.; Bilokon, Olga; Корнацька, А. Г.; Dyndar, O.A.; Trokhymovych, O.V.; Bozhko, Nataliia; Raksha, I.I.; Nykoniuk, T.R.; Gorbunova, O. V.; Kokhanov, Igor V; Kushnirenko, S.V.; Iarotska, Iryna; Golianovsky, Oleg V; Holovanova, I. A.; Abbasova, Esmira R

doi:10.36740/wlek202006119

Cited by 15 publications

(24 citation statements)

References 12 publications

(23 reference statements)

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“…A ten-year surveillance study of pathogens implicated in urinary tract infections revealed a significant increase in the proportions of multidrug-resistant bacteria and fluoroquinolone-resistant E. coli [ 166 ]. The recent studies examined the prevalence of MRSA and Methicillin-resistant Staphylococcus epidermidis (MRSE) and ESBL production among Enterobacteriaceae in postpartum mastitis [ 167 ] and postpartum endometritis [ 168 ]. To date, molecular epidemiological studies are limited in Ukraine [ 169 , 170 ].…”

Section: A Snapshot Of Amr Surveillance Programs and The Epidemiologymentioning

confidence: 99%

Surveillance of antimicrobial resistance in low- and middle-income countries: a scattered picture

Iskandar

Molinier

Hallit

et al. 2021

Antimicrob Resist Infect Control

199

144

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Data on comprehensive population-based surveillance of antimicrobial resistance is lacking. In low- and middle-income countries, the challenges are high due to weak laboratory capacity, poor health systems governance, lack of health information systems, and limited resources. Developing countries struggle with political and social dilemma, and bear a high health and economic burden of communicable diseases. Available data are fragmented and lack representativeness which limits their use to advice health policy makers and orientate the efficient allocation of funding and financial resources on programs to mitigate resistance. Low-quality data means soaring rates of antimicrobial resistance and the inability to track and map the spread of resistance, detect early outbreaks, and set national health policy to tackle resistance. Here, we review the barriers and limitations of conducting effective antimicrobial resistance surveillance, and we highlight multiple incremental approaches that may offer opportunities to strengthen population-based surveillance if tailored to the context of each country.

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Section: A Snapshot Of Amr Surveillance Programs and The Epidemiologymentioning

confidence: 99%

Surveillance of antimicrobial resistance in low- and middle-income countries: a scattered picture

Iskandar

Molinier

Hallit

et al. 2021

Antimicrob Resist Infect Control

199

144

View full text Add to dashboard Cite

show abstract

“…Infections at postpartum presents a significant burden to the hospital system and remains a significant cause of maternal mortality and morbidity worldwide ( 39 , 40 ), yet the epidemiology of several post-delivery pathologies including postpartum endometritis, postpartum sepsis and chorioamnionitis remains elusive and has not been well characterized. Postpartum endometritis (PPE) describes an inflammation or infection of the upper genital tract comprising the endometrium, myometrium, and the surrounding tissue.…”

Section: Methodsmentioning

confidence: 99%

Role of short interpregnancy interval, birth mode, birth practices, and the postpartum vaginal microbiome in preterm birth

Odogwu

2023

Front. Reprod. Health

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There have been widely documented beneficial role of vaginal Lactobacillus species as an important biomarker for vaginal health and healthy pregnancy progression. When translating this to clinical settings, pregnant women with low proportions of Lactobacillus and commensurately high proportion of rich and highly diverse abnormal microbiota are most likely to encounter negative pregnancy outcome such as preterm birth and postpartum complications. However, multiple literatures have also addressed this notion that the absence of a Lactobacillus-dominated microbiota does not appear to directly imply to a diseased condition and may not be a major determinant of negative obstetric outcome. Caesarian delivery is notably a risk factor for preterm birth and postpartum endometritis, yet recent data shows a trend in the overuse of CS across several populations. Growing evidence suggest the potential role of vaginal/uterine cleaning practice during CS procedures in influencing postpartum infections, however there is a controversy that this practice is associated with increased rates of postpartum endometritis. The preponderance of bacterial vaginosis associated bacteria vagitype at postpartum which persist for a long period of time even after lochia regression in some women may suggest why short interpregnancy interval may pose a potential risk for preterm birth, especially multigravidas. While specifically linking a community of microbes in the female reproductive tract or an exact causative infectious agent to preterm birth and postpartum pathologies remains elusive, clinical attention should also be drawn to the potential contribution of other factors such as short interpregnancy interval, birth mode, birth practices and the postpartum vaginal microbiome in preterm birth which is explicitly described in this narrative review.

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“…One of the reasons for healthcare-associated infections is the wide spread of conditionally pathogenic microorganisms in Ukraine that are resistant to antibiotics [10,11]. The emergence and spread of antimicrobial resistance has become a major public health threat in Ukraine, and the number of infections caused by resistant pathogens causing of HARTIs continues to increase [12,13].…”

Section: Introductionmentioning

confidence: 99%

Healthcare Associated Deep Pelvic Tissue Infection and Other Infections of the Female Reproductive Tract in Ukraine

et al. 2021

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The aim: To obtain the first estimates of the current prevalence of healthcare-associated deep pelvic tissue infection and other infections of the female reproductive tract (vagina, ovaries, uterus) including chorioamnionitis, and antimicrobial resistance of causing pathogens in Ukraine. Materials and methods: We performed a retrospective multicenter cohort study was based on surveillance data. The study population included 3,053 women’s who underwent gynecological surgery or other procedures from 2017 to 2019 in 7 women hospitals in Ukraine. Definitions of healthcare-associated reproductive tract infection were used from the CDC/ NHSN. Results: The prevalence of healthcare-associated deep pelvic tissue infection and other infections of the female reproductive tract was 26.3%. Incidence of infection was: 13.3% Pelvic abscess or cellulitis, 14.6% Adnexa utery, 9.5% Salpingitis, 7.1% Oophoritis, 12.2% Parametritis, 4.6% Chorioamnionitis, and 38.8% Bacterial Vaginitis. The predominant pathogens were: Escherichia coli (25.6%), Enterobacter spp. (11.4%), Klebsiella pneumoniae (10.6%), Staphylococcus aureus (8.5%), Enterococcus faecalis (7.2%) and Pseudomonas aeruginosa (7.1%). Methicillin-resistance was observed in 14.3% of S. aureus (MRSA). The overall proportion of extended spectrum beta-lactamases (ESBL) production among Enterobacteriaceae was 20.8%. The prevalence of ESBL production among E. coli isolates was 24.7% and among K. pneumoniae 11.9%. Resistance to thirdgeneration cephalosporins was observed in 12.8% E.coli and 9.2% K. pneumoniae isolates. Carbapenem resistance was identified in 8.5% of P.aeruginosa isolates. Conclusions: Healthcare associated deep pelvic tissue infection and other infections of the female reproductive tract in Ukraine is a common occurrence and many cases are caused by pathogens that are resistant to antibiotics.

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Prevalence of Postpartum Endometritis and Antimicrobial Resistance of Responsible Pathogens in Ukraine: Results a Multicenter Study (2015-2017)

Cited by 15 publications

References 12 publications

Surveillance of antimicrobial resistance in low- and middle-income countries: a scattered picture

Surveillance of antimicrobial resistance in low- and middle-income countries: a scattered picture

Role of short interpregnancy interval, birth mode, birth practices, and the postpartum vaginal microbiome in preterm birth

Healthcare Associated Deep Pelvic Tissue Infection and Other Infections of the Female Reproductive Tract in Ukraine

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