Prevalence of Occult Hepatitis C Virus Infection among Blood Donors in Jiangsu, China

Lin, Hong; Chen, Xian; Zhu, Sha; Mao, Ping; Zhu, Shanshan; Huang, Chengyin; Sun, Jun; Zhu, Jin

doi:10.1159/000455854

Cited by 23 publications

(22 citation statements)

References 27 publications

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“…The pattern can be used for predicting the paths for a new patient. In [8], hidden Markov model (HMM) was adopted for inferring the CP pattern, which was useful in knowledge sharing and CP updating. While these methods were severely limited to the data deficiency and complexity and because CPs focus on the order relations between various clinical events, process mining technologies are widely used for CPM.…”

Section: Related Workmentioning

confidence: 99%

Incorporating Topic Assignment Constraint and Topic Correlation Limitation into Clinical Goal Discovering for Clinical Pathway Mining

Xiao

Jin

Wei

et al. 2017

Journal of Healthcare Engineering

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Clinical pathways are widely used around the world for providing quality medical treatment and controlling healthcare cost. However, the expert-designed clinical pathways can hardly deal with the variances among hospitals and patients. It calls for more dynamic and adaptive process, which is derived from various clinical data. Topic-based clinical pathway mining is an effective approach to discover a concise process model. Through this approach, the latent topics found by latent Dirichlet allocation (LDA) represent the clinical goals. And process mining methods are used to extract the temporal relations between these topics. However, the topic quality is usually not desirable due to the low performance of the LDA in clinical data. In this paper, we incorporate topic assignment constraint and topic correlation limitation into the LDA to enhance the ability of discovering high-quality topics. Two real-world datasets are used to evaluate the proposed method. The results show that the topics discovered by our method are with higher coherence, informativeness, and coverage than the original LDA. These quality topics are suitable to represent the clinical goals. Also, we illustrate that our method is effective in generating a comprehensive topic-based clinical pathway model.

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Section: Related Workmentioning

confidence: 99%

Incorporating Topic Assignment Constraint and Topic Correlation Limitation into Clinical Goal Discovering for Clinical Pathway Mining

Xiao

Jin

Wei

et al. 2017

Journal of Healthcare Engineering

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“…Three of these 42 donors (7.1%) had occult HCV infection. In another recent study in China that included blood samples from blood donors that were anti-HCV negative and in which it was determined in PBMC, a prevalence of 2.2% was found [17].…”

Section: Discussionmentioning

confidence: 97%

Epidemiological and clinical implications in Kidney Transplantation of occult Hepatitis C virus infection

Olea¹,

Castillo²,

Jiménez³

et al. 2019

Arch Clin Nephrol

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Occult Hepatitis C virus (HCV) infection (OCI) is characterized by the presence of HCV-RNA in liver or in peripheral blood mononuclear cells (PBMC) in the absence of serological markers. HCV infection in kidney transplant (KT) recipients is associated with lower patient and graft survival. However, the relationship between KT outcome and OCI is unknown. Our aim was to determine in KT recipients the prevalence, risk factors for OCI, and its prognostic implications. We tested 149 adults KT recipients for the presence of OCI. HCV-RNA was tested by a RT-PCR in PBMC and in 2 ml of plasma after ultracentrifugation. OCI was positive in 21 patients (14.1%). Previous blood transfusion was a risk factor for acquiring OCI (p=0.044). Although there were no statistical differences in clinical complications post-KT and in the immunosuppression, graft and patient survival were worse in the OCI positive group (p=0.02 and p=0.04, respectively). In summary, there was a high prevalence of OCI in our KT population with previous blood transfusion as the main risk factor. Long-term graft and patient survival were reduced as compared to OCI negative recipients although the contribution of particular co-morbidities did not reach statistical signifi cance.

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“…This result closed to other investigation of Shazly et al (2015) [21] who documented that OCI was 4% in healthy Egyptian individual partners of patients infected with chronic HEPATITIS C VIRUS genotype 4 infection. Also in hemodialysis patients Abdurrahman et al (2016) [22] detect OCI (3.7%) in 81 at Mania-Egypt, Also Maria de la Luz Martinez-Rodríguez 2018 [23] in Mexico City documented OCI 3.4% in blood donors Samples, Lin H 2016 documented OCI 2.2%in China [24] and Quinoa JA 2016 OCI is 2.1% Spain [25].…”

Section: Discussionmentioning

confidence: 99%

Occult Hepatitis C Virus in Blood Donors in Damietta - Egypt

Abdeldayem¹

2019

AJLM

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Egypt maintains the highest prevalence of hepatitis C virus infection, affecting an estimated 15%-20% of the population, new cases reported, so we search about uncommon source of hepatitis C virus infection. Occult hepatitis C Virus infection can be detected and founded in the overall public obviously haven't any diseases, Detection of viral replication in PBMCs may increase spread and transmission of hepatitis C virus during blood transfusion, hemodialysis, and made liver disease development in occult Hepatitis C Virus infected individual. The present study aimed to detect the occult hepatitis C virus infection in healthy blood donors from Damietta-Egypt, And detection of Hepatitis C Virus core antigen. One hundred and fifty blood donors from El-Azhar University Hospital blood bank in New Damietta City were used into the present study. Detection of Hepatitis C Virus RNA in Peripheral blood mononuclear (PBMCs) and plasma by reverse transcription nested polymerase chain reaction (RT-PCR), and also detection of hepatitis C virus core antigen from plasma by ELISA. We founded that: Detection of hepatitis C virus RNA by nested PCR from PBMC among studied donors are eleven (7.9%) on the other hand Hepatitis C Virus RNA in plasma are two (1.4%) so occult C virus are 9/140 (6.4%). By comparison between results of Hepatitis C Virus core Ag and PCR evidence sensitivity 27%, specificity 98.4% in PBMC and sensitivity 100%, specificity 97.8% in Plasma.

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Prevalence of Occult Hepatitis C Virus Infection among Blood Donors in Jiangsu, China

Cited by 23 publications

References 27 publications

Incorporating Topic Assignment Constraint and Topic Correlation Limitation into Clinical Goal Discovering for Clinical Pathway Mining

Incorporating Topic Assignment Constraint and Topic Correlation Limitation into Clinical Goal Discovering for Clinical Pathway Mining

Epidemiological and clinical implications in Kidney Transplantation of occult Hepatitis C virus infection

Occult Hepatitis C Virus in Blood Donors in Damietta - Egypt

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