Prevalence of Metabolic Syndrome Associated with Body Burden Levels of Dioxin and Related Compounds among Japan’s General Population

Uemura, Hirokazu; Arisawa, Kokichi; Hiyoshi, Mineyoshi; Kitayama, Atsushi; Takami, Hidenobu; Sawachika, Fusakazu; Dakeshita, Satoru; Nii, Kentaro; Satoh, Hiroshi; Sumiyoshi, Yoshio; Morinaga, Kenji; Kodama, Kazunori; Suzuki, Tsuneo; Nagai, Masaki; Suzuki, Tsuguyoshi

doi:10.1289/ehp.0800012

Cited by 148 publications

(112 citation statements)

References 32 publications

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“…However, when congeners of PCBs were assessed separately, only the 118 and 126 DL-PCB congeners showed a positive and significant association. Moreover, Uemura et al, 6 who evaluated only the DL-PCBs among general Japanese population, observed an adjusted odds ratio for hypertension of 1.9 (95% CI, 1.1-3.1) and P for trend <0.01 for the highest quartile of DL-PCBs versus the first quartile.…”

Section: Discussionmentioning

confidence: 99%

Association Between Dietary Intake of Polychlorinated Biphenyls and the Incidence of Hypertension in a Spanish Cohort

et al. 2015

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Polychlorinated biphenyls are persistent organic pollutants that are consumed because of their bioaccumulation through the food chain. Evidence from different sources suggests a positive association between polychlorinated biphenyls exposure and the incidence of hypertension. However, no previous prospective study has investigated this potential relationship in adults. We prospectively assessed the association between dietary intake of polychlorinated biphenyls and the incidence of hypertension in a large cohort. The Seguimiento Universidad de Navarra project is a Spanish cohort of university graduates, most of them health professionals. We included 14521 participants, initially free of hypertension, who were followed-up for a median of 8.3 years. Dietary intake of polychlorinated biphenyls was assessed at baseline through a previously validated 136-item semiquantitative food frequency questionnaire. The published concentration levels of polychlorinated biphenyls measured in samples of food consumed in Spain were used to estimate dietary intake. Multivariable Cox regression models were fitted to estimate hazard ratios and 95% confidence interval for incident hypertension. During follow-up, 1497 incident cases of medically diagnosed hypertension were identified. After adjusting for total energy intake and for potential confounders, participants in the fifth quintile of total polychlorinated biphenyls intake were at higher risk of developing hypertension (adjusted hazard ratio, 1.43 [95% confidence interval, 1.09–1.88; P for trend 0.017]) compared with those in the first quintile. In this Mediterranean cohort, dietary intake of polychlorinated biphenyls, estimated using a food frequency questionnaire, was associated with a higher risk of developing hypertension during follow-up. Nevertheless, further longitudinal studies are needed to confirm our results.

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Section: Discussionmentioning

confidence: 99%

Association Between Dietary Intake of Polychlorinated Biphenyls and the Incidence of Hypertension in a Spanish Cohort

et al. 2015

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“…Coupled with the reported association of coplanar PCB exposure and metabolic syndrome (Uemura et al, 2009), this highlights an important area for future risk assessment.…”

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confidence: 83%

Non-coplanar polychlorinated biphenyls (PCBs) are direct agonists for the human pregnane-X receptor and constitutive androstane receptor, and activate target gene expression in a tissue-specific manner

Al-Salman

Plant

2012

Toxicology and Applied Pharmacology

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“…The purpose of this project is to collect data on blood levels and the dietary intake of dioxins and other chemical substances and their determinants in Japanese populations without occupational exposure 12,13) . The surveys were carried out in five regional blocks: Hokkaido/Tohoku, Kanto/Koshin-etsu, Tokai/Hokuriku/ Kinki, Chugoku/Shikoku, and Kyushu/Okinawa.…”

Section: Study Subjectsmentioning

confidence: 99%

Consumption of Seafood, Serum Liver Enzymes, and Blood Levels of PFOS and PFOA in the Japanese Population

Yamaguchi

Arisawa

Uemura

et al. 2013

Journal of Occupational Health

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PFOA, with medians being highest in the Tokai/Hokuriku/ Kinki region. Conclusions: These findings suggest that the concentrations of PFOS in blood were mainly associated with fish consumption and that the levels of PFOS and PFOA were associated with the serum levels of liver enzymes in Japanese populations. Further investigations are required to clarify the reason for the regional differences in blood levels of PFOS and PFOA in Japan. (J Occup Health 2013; 55: 184−194) Key words: Blood, Fish intake, Perfluorooctanesulfonate (PFOS), Perfluorooctanoate (PFOA), Serum liver enzymes Perfluorochemicals (PFCs) are man-made chemical substances containing C-C and C-F bonds. PFCs are extremely resistant to degradation, and accumulate in the environment. Perfluorooctanesulfonate (PFOS) and perfluorooctanoate (PFOA) are two of the main PFCs. PFOS and PFOA have both hydrophilic and lipophilic properties. PFOS bioaccumulates in animal tissues through the food web 1) , and exposure to PFOA occurs in part through drinking water and beverages 2) . The geometric mean elimination half-lives of PFOS and PFOA from human serum are approximately 4.8 and 3.5 years, respectively 3) . Recently, it has been reported that PFOS and PFOA have toxic effects on wildlife and humans. The toxicity includes neurobehavioral defects 4) , hepatotoxicity 5) , immune toxicity and carcinogenicity 6) . A reduction in human exposure to PFCs has been reported following the phasing-out of perfluorosulfonyl-based compounds and the Environmental Protection Agency's program The purpose of the present study was to examine the factors associated with the blood levels of PFOS and PFOA. Methods: A cross-sectional study was performed on 307 men and 301 women (aged 16−76 years) living in 15 prefectures in Japan. Blood levels of PFOS and PFOA were measured by liquid chromatography-mass spectrometry. Hepatic enzymes (γ -GTP, GOT, and GPT) and ω -3 polyunsaturated fatty acids (DHA and EPA) levels in serum were also measured. Associations between the levels of PFOS and PFOA in blood and the intake frequency of 41 kinds of dishes, foods and beverages and the serum levels of liver enzymes and ω -3 polyunsaturated fatty acids were examined using rank correlations. Results: Frequency of intake of boiled fish in broth, sliced raw fish and coastal fish showed significant positive correlations with PFOS concentrations in blood after adjustments for potential confounders. Serum levels of GOT, GPT, DHA and EPA showed significant positive correlations with PFOS and PFOA in blood. There was also a significant regional difference in the blood levels of PFOS and

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Prevalence of Metabolic Syndrome Associated with Body Burden Levels of Dioxin and Related Compounds among Japan’s General Population

Cited by 148 publications

References 32 publications

Association Between Dietary Intake of Polychlorinated Biphenyls and the Incidence of Hypertension in a Spanish Cohort

Association Between Dietary Intake of Polychlorinated Biphenyls and the Incidence of Hypertension in a Spanish Cohort

Non-coplanar polychlorinated biphenyls (PCBs) are direct agonists for the human pregnane-X receptor and constitutive androstane receptor, and activate target gene expression in a tissue-specific manner

Consumption of Seafood, Serum Liver Enzymes, and Blood Levels of PFOS and PFOA in the Japanese Population

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