Prevalence of JC Virus Viraemia in HIV-Infected Patients with or Without Neurological Disorders: A Prospective Study

Dubois, Vivien; Moret, Hélène; Lafon, Marie‐Edith; Janvresse, C; Dussaix, Élisabeth; Icart, J.; Karaterki, Amina; Ruffault, Annick; Taoufik, Yacine; Vignoli, C.; Ingrand, D.

doi:10.3109/13550289809113498

Cited by 30 publications

(22 citation statements)

References 26 publications

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“…In patients with HIV/AIDS, absence of JCV DNA in blood has been shown to be associated with a low probability of developing PML. 34 The significance of JC viremia, or absence of it and its potential as a PML screening tool in recipients of HCT remains to be assessed.…”

Section: Discussionmentioning

confidence: 99%

Two cases of progressive multifocal leukoencephalopathy after allogeneic hematopoietic cell transplantation and a review of the literature

Kharfan‐Dabaja

Ayala

Greene

et al. 2006

Bone Marrow Transplant

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Progressive multifocal leukoencephalopathy (PML) is a rare subacute demyelinating disorder of the central nervous system (CNS) caused by the DNA JC human polyomavirus. In immunocompromised hosts, PML is caused by reactivation of a latent infection rather than de novo primary exposure. PML in the setting of hematopoietic cell transplantation (HCT) is exceedingly rare. PML should be considered in the differential diagnosis of HCT recipients, autologous or allogeneic, presenting with worsening of neurological symptoms, especially associated with post-transplant neurodegenerative findings. Although DNA polymerase chain reaction (PCR) of the cerebrospinal fluid (CSF) has emerged as a promising tool for detecting JC virus, a negative result does not rule out PML. Brain biopsy remains the most reliable and accurate method for diagnosing JC virus-associated PML. Presently, there is no universally effective antiviral therapy against JC virus and outcome is fatal in the majority of cases. We hereby describe two cases of PML developing after allogeneic HCT and provide a comprehensive review of the literature.

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Section: Discussionmentioning

confidence: 99%

Two cases of progressive multifocal leukoencephalopathy after allogeneic hematopoietic cell transplantation and a review of the literature

Kharfan‐Dabaja

Ayala

Greene

et al. 2006

Bone Marrow Transplant

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“…The JCV DNA load in the peripheral blood mononuclear cells (PBMC) is very low, between 10 and 90 copies of JCV/g of PBMC DNA (16), and becomes detectable only after PCR amplification and the application of hybridization techniques. JCV has also been detected in cellfree plasma (7,16,17). A recent report has demonstrated that JCV sticks to the surfaces of blood cells rather than productively infecting them (30).…”

mentioning

confidence: 93%

JC Virus Regulatory Region Tandem Repeats in Plasma and Central Nervous System Isolates Correlate with Poor Clinical Outcome in Patients with Progressive Multifocal Leukoencephalopathy

Pfister

Letvin

Koralnik

2001

J Virol

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“…This virus has also been detected in B-lymphocyte-depleted peripheral blood leukocytes of HIV-infected individuals (Dubois et al, 1997) and in brain macrophages of patients with PML (Orenstein et al, 1988;Stoner et al, 1986;Boldorini et al, 1993). Finally, JCV has been found in cell-free plasma of immunosuppressed individuals (Dubois et al, 1997(Dubois et al, , 1998Koralnik et al, 1999). These disparate observations do not provide a coherent picture of how JCV might be transported from the kidney into the CNS to initiate demyelinating disease.…”

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confidence: 93%

Detection of JC virus DNA in peripheral blood cell subpopulations of HIV-1-infected individuals

Koralnik¹,

Schmitz²,

Lifton³

et al. 1999

J Neurovirol

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While it has been suggested that JC virus (JCV) migrates in B-lymphocytes from the kidney to the central nervous system where it initiates demyelination, this phase of JCV pathogenesis has not been systematically explored. To determine the peripheral blood cell subpopulation(s) infected with JCV, monocytes, granulocytes, and T and B lymphocytes from HIV-1-infected individuals and uninfected controls were puri®ed by¯ow cytometry. JCV DNA could be detected by PCR ampli®cation in all of these cell subpopulations. This ®nding suggests that JCV lacks speci®city in its interaction with leukocytes.

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Prevalence of JC Virus Viraemia in HIV-Infected Patients with or Without Neurological Disorders: A Prospective Study

Cited by 30 publications

References 26 publications

Two cases of progressive multifocal leukoencephalopathy after allogeneic hematopoietic cell transplantation and a review of the literature

Two cases of progressive multifocal leukoencephalopathy after allogeneic hematopoietic cell transplantation and a review of the literature

JC Virus Regulatory Region Tandem Repeats in Plasma and Central Nervous System Isolates Correlate with Poor Clinical Outcome in Patients with Progressive Multifocal Leukoencephalopathy

Detection of JC virus DNA in peripheral blood cell subpopulations of HIV-1-infected individuals

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