Prevalence of influenza <scp>A</scp> infection in the <scp>M</scp>iddle‐<scp>E</scp>ast: A systematic review and meta‐analysis

Moghoofei, Mohsen; Monavari, Seyed Hamidreza; Mostafaei, Shayan; Hadifar, Shima; Ghasemi, Amir; Babaei, Farhad; Kavosi, Hoda; Tavakoli, Ahmad; Javanmard, Davod; Esghaei, Maryam; Khodabandehlou, Nilofar

doi:10.1111/crj.12758

Cited by 20 publications

(17 citation statements)

References 78 publications

(53 reference statements)

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“…The average annual positivity rate (the number of positive tests divided by the total number of requested tests) for tested patients was 14% and this is similar to the positivity rate (13.4%) reported by the Lebanese SARI Sentinel Surveillance conducted by the Ministry of Public Health for the 2015/2016 season [37]. Moghoofei et al estimated an influenza infection prevalence of 10% in the Middle East that approaches our positivity rate in Lebanon [38]. In his systematic review, 71 studies were included of which only one study was from Lebanon but included a very small sample size [30].…”

Section: Discussionsupporting

confidence: 84%

The burden of laboratory-confirmed influenza infection in Lebanon between 2008 and 2016: a single tertiary care center experience

et al. 2020

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Background: Influenza is a major cause of morbidity and mortality worldwide. Following the 2009 pandemic, there was widened interest in studying influenza burden in all regions. However, since data from the World Health Organization (WHO) Middle East and North Africa (MENA) region remain limited, we aimed to contribute to the understanding of influenza burden in Lebanon. Methods: A retrospective chart review extending over a period of 8 seasons from Jan 1st, 2008 till June 30th, 2016 at a tertiary care center in Beirut was performed. All cases confirmed to have influenza based on rapid antigen detection or/and polymerase chain reaction on a respiratory sample were included for analysis. Data on epidemiology, clinical presentation, complications, antiviral use and mortality were collected for analysis.

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Section: Discussionsupporting

confidence: 84%

The burden of laboratory-confirmed influenza infection in Lebanon between 2008 and 2016: a single tertiary care center experience

et al. 2020

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“…In humans, influenza A virus (IAV) is a common respiratory pathogen, having the potential to lead global pandemics. Significantly, this virus is capable of replicating throughout the respiratory tract . Human nasal epithelium performs as an essential barrier, which protects against respiratory infections.…”

Section: Mir‐146a In Influenzamentioning

confidence: 99%

“…Significantly, this virus is capable of replicating throughout the respiratory tract. 90,91 Human nasal epithelium performs as an essential barrier, which protects against respiratory infections. The inflammatory pathways modulation in the respiratory tract that causes a decrease of respiratory functions and epithelium damage is an alternative defense strategy against influenza infection.…”

Section: Mir-146a In Influenzamentioning

confidence: 99%

The role of miR‐146a in viral infection

et al. 2019

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Cellular microRNAs (miRNAs) were identified as a key player in the posttranscriptional regulation of cellular‐genes regulatory pathways. They also emerged as a significant regulator of the immune response. In particular, miR‐146a acts as an importance modulator of function and differentiation cells of the innate and adaptive immunity. It has been associated with disorder including cancer and viral infections. Given its significance in the regulation of key cellular processes, it is not surprising which virus infection have found ways to dysregulation of miRNAs. miR‐146a has been identified in exosomes (exosomal miR‐146a). After the exosomes release from donor cells, they are taken up by the recipient cell and probably the exosomal miR‐146a is able to modulate the antiviral response in the recipient cell and result in making them more susceptible to virus infection. In this review, we discuss recent reports regarding miR‐146a expression levels, target genes, function, and contributing role in the pathogenesis of the viral infection and provide a clue to develop the new therapeutic and preventive strategies for viral disease in the future.

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“…Because success of the same antimicrobial stewardship intervention can vary across clinical networks, metrics that take into account the dynamics between prescribers and the antimicrobial stewardship team can provide insight into how well an intervention will be incorporated into the local culture of practice. 4,5,9,10 Further research identifying, measuring, and accounting for stages of behavioral change in the evaluation of antimicrobial stewardship improvement strategies will provide insight into how to adapt and integrate these initiatives across various healthcare settings.…”

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confidence: 99%

Applying behavioral frameworks to antimicrobial stewardship

Thampi

Szymczak

Leis

2020

Infect. Control Hosp. Epidemiol.

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Use respiratory masks during close contact with people, and try to change the masks often. 4) Maintain several meters distance from other pilgrims. 5) Avoid contact with other pilgrims who appear ill. 6) Obtain vaccination (high-risk individuals). 7) Avoid shaking hands and kissing during greetings. 8) Wear mask and gloves during the pilgrimage and touching the shrine. Also, if individuals appear with signs and symptoms of flu, the following measures should be taken 15 : 1) Use a mask to cover the mouth and nose. 2) Cover the nose and mouth with their arm/sleeve or a napkin when sneezing or coughing. 3) Placed used napkin or tissue in a plastic bag, then close the bag and throw it in the trash. Observing such measures can greatly reduce the spread of influenza virus during the Arba'een pilgrimage.

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Prevalence of influenza A infection in the Middle‐East: A systematic review and meta‐analysis

Abstract: The results of this review are remarkable, they show that influenza infection RF is variable due to several factors. Thus, further researches should be taken to minimize the emergence and transmission of influenza virus.

Cited by 20 publications

References 78 publications

The burden of laboratory-confirmed influenza infection in Lebanon between 2008 and 2016: a single tertiary care center experience

The burden of laboratory-confirmed influenza infection in Lebanon between 2008 and 2016: a single tertiary care center experience

The role of miR‐146a in viral infection

Applying behavioral frameworks to antimicrobial stewardship

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