Prevalence of Influenza A(H1N1)pdm09 Virus Resistant to Oseltamivir in Shiraz, Iran, During 2012 - 2013

Khodadad, Nastaran; Moattari, Afagh; Abadi, Mahmoud Shamsi Shahr; Kadivar, Mohammad Rahim; Sarvari, Jamal; Tavakoli, Forough; Pirbonyeh, Neda

doi:10.5812/jjm.23690

Cited by 13 publications

(10 citation statements)

References 22 publications

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“…The mortality rate was 140 (3.8%) [12]. In the present study, of 123 patients diagnosed with the possible diagnosis of influenza, a positive PCR for H1N1was detected in 58 (47.2%), which is higher than other studies in our country [13]. This can be because of better sampling and more precise clinical suspicion in the diagnosis of patients, even though it is probable that true H1N1 cases are higher and our test had also false negative results because of treatment having begun before testing.…”

Section: Discussioncontrasting

confidence: 61%

Clinical and laboratory findings of patients with the possible diagnosis of influenza hospitalized in affiliated hospitals of Babol University of Medical Sciences, 2015-2016

Javanian

Babazadeh

Ebrahimpour

et al. 2018

Current Issues in Pharmacy and Medical Sciences

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The clinical and para clinical manifestations of influenza in various patients have range from an autoimmune disease to a life-threatening respiratory infection. In addition, the severity of the disease is influenced by factors such as demographic factors, underlying diseases, and immune response. Therefore, in this study, we evaluated the clinical, laboratory and epidemiological characteristics of patients with this type of influenza in Babol (north of Iran). This study was conducted as a descriptive cross-sectional study from October 2015 to March 2016. Subsequently, in this study, records of 123 patients with clinical signs of the influenza-like disease who have undergone the clinical sign in hospitals affiliated to Babol University of Medical Sciences were reviewed. Of 123 patients admitted to a possible diagnosis of influenza, 58 patients (47.2%) were PCR positive for H1N1, while seventy nine (64.2%) participants were women and 21 (17.1%) had diabetes or underlying lung disease. Most of the involved age groups were of individuals above the age of 50. These were followed by the 21-35 years-old. Fever (78%), cough (65.9%), shivering (58.5%) and myalgia (56.1%) were the most common clinical symptoms. Increased levels of transaminases (43.1%), leukocytosis (35.8%) and thrombocytopenia (34.2%) were as well reported in patients as the most frequently reported para clinical findings. In the present study, the most usual clinical symptoms were fever, cough, chill, and myalgia, while gastrointestinal symptoms were also noticeably observed in patients. In an experimental study, a significant number of patients showed leukocytosis and thrombocytopenia and increased transaminases.

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Section: Discussioncontrasting

confidence: 61%

Clinical and laboratory findings of patients with the possible diagnosis of influenza hospitalized in affiliated hospitals of Babol University of Medical Sciences, 2015-2016

Javanian

Babazadeh

Ebrahimpour

et al. 2018

Current Issues in Pharmacy and Medical Sciences

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“…In a similar study conducted in Beijing, China, all of the A/H1N1 pdm09 viruses isolated in 2012-2013 were sensitive to oseltamivir. 26 Circulating strains of the virus during influenza season in Nepal revealed many similarities with our neighboring countries and the region. Our finding showed year-round transmission with a peak influenza activity during the rainy and winter season is similar to Thailand, Northern Vietnam and Lao-PDR.…”

Section: Discussionmentioning

confidence: 93%

Molecular Epidemiology and Antigenic Characterization of Seasonal Influenza Viruses Circulating in Nepal

Upadhyay

Ghimire

Tashiro

et al. 2017

J Nepal Health Res Council

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Background: Influenza is one of the public health burdens in Nepal and its epidemiology is not clearly understood. The objective of this study was to explore the molecular epidemiology and the antigenic characteristics of the circulating influenza viruses in Nepal.Methods: A total of 1495 throat swab specimens were collected from January to December, 2014. Real time PCR assay was used for identification of influenza virus types and subtypes. Ten percent of the positive specimens were randomly selected and inoculated onto Madin-Darby Canine Kidney Epithelial cells (MDCK) for influenza virus isolation. All viruses were characterized by the hemagglutination inhibition (HI) assay.Results: Influenza viruses were detected in 421/1495 (28.2%) specimens. Among positive cases, influenza A virus was detected in 301/421 (71.5%); of which 120 (39.9%) were influenza A/H1N1 pdm09 and 181 (60.1%) were influenza A/H3 subtype. Influenza B viruses were detected in 119/421 (28.3%) specimens. Influenza A/H1N1 pdm09, A/H3 and B viruses isolated in Nepal were antigenically similar to the vaccine strain influenza A/California/07/2009(H1N1pdm09), A/Texas/50/2012(H3N2), A/New York/39/2012(H3N2) and B/Massachusetts/2/2012, respectively.Conclusions: Influenza viruses were reported year-round in different geographical regions of Nepal which was similar to other tropical countries. The circulating influenza virus type and subtypes of Nepal were similar to vaccine candidate virus which could be prevented by currently used influenza vaccine.

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“…Drug resistance strains were not found among the strains of influenza B virus [8]. However the recent data suggest the development of resistance to the neuraminidase inhibitors from 0 to 64% of isolates of influenza A and B viruses in different countries [36].…”

Section: Resultsmentioning

confidence: 96%

Levels of Antiviral Therapy

Ap¹,

Turmagambetova²,

Berezin³

2016

JHVRV

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Prevalence of Influenza A(H1N1)pdm09 Virus Resistant to Oseltamivir in Shiraz, Iran, During 2012 - 2013

Cited by 13 publications

References 22 publications

Clinical and laboratory findings of patients with the possible diagnosis of influenza hospitalized in affiliated hospitals of Babol University of Medical Sciences, 2015-2016

Clinical and laboratory findings of patients with the possible diagnosis of influenza hospitalized in affiliated hospitals of Babol University of Medical Sciences, 2015-2016

Molecular Epidemiology and Antigenic Characterization of Seasonal Influenza Viruses Circulating in Nepal

Levels of Antiviral Therapy

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