Prevalence of IgA antitissue transglutaminase antibodies in children with type 1 diabetes mellitus

Samaşcă, Gabriel; Ilie, Mihaela; Butnariu, Angela; Andreica, Mariana; Doru, Dejica

doi:10.1002/jcla.20449

Cited by 15 publications

(7 citation statements)

References 8 publications

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“…This recommendation is based on the study of Leeds et al [13] who observed that CD-T1D patients have a higher HbA1c level in comparison with T1D adult patients (8.2% vs. 7.5%, p =0.05). Similarly, our study confirms these findings and shows a significantly elevated median of HbA1c level in seropositive cases, in contrary to several series showing no significant difference [23, 27, 28, 31, 35, 47–49].…”

Section: Discussionsupporting

confidence: 92%

The Prevalence of Celiac Disease-Specific Auto-Antibodies in Type 1 Diabetes in a Moroccan Population

Oujamaa

Sebbani

Elmoumou

et al. 2019

International Journal of Endocrinology

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Objective. We aimed to determine the prevalence of specific auto-antibodies to celiac disease (CD) in Moroccan type 1 diabetic (T1D) patients and compare the clinical and biological characteristics of seropositive and seronegative cases. Patients and Methods. A cross-sectional study was carried out on 276 T1D patients including 109 adults and 167 pediatric cases. The screening for CD was performed by an Elisa IgA anti-tissue transglutaminase antibody (tTGA) testing, combined with IgA quantification by nephelometry. Positive-IgA-tTGA cases were secondly tested for anti-endomysial antibodies (EMA) using an immunofluorescence technique, and the IgA deficiency cases were screened for IgG-tTGA. Patients with low positive tTGA titers underwent HLA-DQ2/DQ8 typing. Sociodemographic and clinical data of the patients were collected using a hetero-administered questionnaire. The comparison of clinical and biological data between seropositive and seronegative diabetics was done using independent T, Mann–Whitney U, chi-squared, and Fisher tests, which were considered significant if p value <0.05. Results. The prevalence of CD-specific auto-antibodies was estimated to be 9.1% (IC = 95%), with 25 positive cases in tTGA and EMA testing. Eight cases displayed low titers of IgA-tTGA, among which 4 were positive for HLA-DQ2, 1 for HLA-DQ8, and 1 for both DQ2 and DQ8. The other 2 cases had a biopsy-proven CD. Compared to seronegative patients, seropositive cases had a higher percentage of associated autoimmune disorders (16% vs. 2.4%, p=0.008), with a significant lower height Z-scores (median: −0.90 (−3.93 to 0.95) vs. −0.51 (−4.54 to 2.18), p=0.029) and a higher HbA1c level (median: 11.30% (7.31 to 16.00) vs. 9.30% (4.40 to17.31), p=0.022). Conclusion. The current study gave evidence of a high prevalence of CD specific auto-antibodies in T1D population. The co-existence of these two conditions was associated with a poor glycemic control, a lower height, and other autoimmune diseases. These findings may suggest the necessity of a systematic screening of CD in T1D patients.

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Section: Discussionsupporting

confidence: 92%

The Prevalence of Celiac Disease-Specific Auto-Antibodies in Type 1 Diabetes in a Moroccan Population

Oujamaa

Sebbani

Elmoumou

et al. 2019

International Journal of Endocrinology

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“…The CD prevalence among the T1DM patients in Romania was 3.9% that is comparable with European studies in adult patient with CD [29]. The IgA anti-tTG prevalence in children with T1DM was 9.2%, and sensitivity and specificity of IgA anti-tTG were 80 and 82.6% [30]. Another association of CD is with Turner syndrome, in which besides GFD, the patient requires endocrine treatment [31].…”

Section: Medical Considerationssupporting

confidence: 61%

News in Celiac Disease about Differential Diagnosis from Romania

Sur¹,

Pîrvan²,

Deleanu³

et al. 2016

IJCD

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“…Sixty‐two studies on the prevalence of CD in patients with type 1 diabetes were included in this review . The prevalence of EMA positivity ranged from 0% to 13.83%; that of elevated tTG levels ranged from 0.81% to 21.16%, while 0.40% to 12.16% showed villous atrophy, ‘flat biopsies’ or Marsh 3 histological changes.…”

Section: Resultsmentioning

confidence: 99%

Systematic review: worldwide variation in the frequency of coeliac disease and changes over time

Kang

Green

et al. 2013

Aliment Pharmacol Ther

230

182

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Summary Background Coeliac disease (CD), originally thought to be largely confined to Northern Europe and Australasia and uncommon in North America and the Middle East, is now recognised to be equally common in all these countries. It is still thought to be rare in the Orient and Sub‐Saharan Africa. Aim To assess geographical differences and time trends in the frequency of CD. Methods Medline and Embase searches were conducted on 10 November 2012, from 1946 and 1980 respectively, using the key words: coeliac disease or celiac disease + prevalence or incidence or frequency. Results There were significant intra‐ and inter‐country differences in the prevalence and incidence of CD. Only 24 ethnic Chinese and Japanese patients have been reported in the English literature. Of CD‐associated HLA DQ antigens, DQ2 occurs in 5–10% of Chinese and sub‐Saharan Africans, compared to 5–20% in Western Europe. DQ8 occurs in 5–10% of English, Tunisians and Iranians, but in <5% of Eastern Europeans, Americans and Asians. The prevalence and incidence of both clinically and serologically diagnosed CD increased in recent years. These geographical and temporal differences seem genuine, although variable indices of suspicion and availability of diagnostic facilities are confounding factors. Conclusions Coeliac disease is increasing in frequency, with significant geographical differences. Although few cases have been described to date in the Orient and Sub‐Saharan Africa, there is a significant prevalence of HLA DQ2 and wheat consumption is of the same order as that in Western Europe. CD may therefore become more common in the future in these countries.

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Prevalence of IgA antitissue transglutaminase antibodies in children with type 1 diabetes mellitus

Abstract: There is an increased prevalence of IgA antitissue transglutaminase antibodies, which suggests the need to use this method as an effective first-line test in the screening of celiac disease in children with type 1 diabetes mellitus.

Cited by 15 publications

References 8 publications

The Prevalence of Celiac Disease-Specific Auto-Antibodies in Type 1 Diabetes in a Moroccan Population

The Prevalence of Celiac Disease-Specific Auto-Antibodies in Type 1 Diabetes in a Moroccan Population

News in Celiac Disease about Differential Diagnosis from Romania

Systematic review: worldwide variation in the frequency of coeliac disease and changes over time

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