Prevalence ofHelicobacter pylori vacA,cagA, andiceAGenotypes in Cuban Patients with Upper Gastrointestinal Diseases

Feliciano, Onelkis; Gutiérrez, Óscar; Valdés, Lidunka; Fragoso, T; Calderin, Ana Maria; Valdes, Antonio Eduardo; Llanes, Rafael

doi:10.1155/2015/753710

Cited by 42 publications

(26 citation statements)

References 39 publications

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“…Our results were in agreement with Ngoyi et al [35] and lower than Rasheed et al [36]. Feliciano et al [37] reported that during upper endoscopy, patient's mucosa was distributed into non-peptic ulcer dyspepsia in 64.7% and peptic ulcer in 35.3%of cases. Other endoscopic findings (31.7%) were observed among the studied H. pylori infected patients.…”

supporting

confidence: 93%

Helicobacter Pylori Infection in Egyptian Patients With Dyspepsia: Diagnostic, Demographic, Endoscopic and Clinical Characteristics.

Diab¹,

Shenawy²,

Shemis³

et al. 2018

IJAR

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Helicobacter pylori, PCR, rapid urease test, stool antigen. was revealed in 27(45%) and 10 (16.7%) had peptic ulcer disease (PUD). Conclusions: H. pylori infection rate in Egyptian patients with dyspepsia was high and gastritis was the most revealed finding upon endoscopy. No risk factors were associated with H. pylori infection among the studied adult patients. Combined rapid urease and stool antigen tests can be relied upon for detecting H. pylori infection.

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supporting

confidence: 93%

Helicobacter Pylori Infection in Egyptian Patients With Dyspepsia: Diagnostic, Demographic, Endoscopic and Clinical Characteristics.

Diab¹,

Shenawy²,

Shemis³

et al. 2018

IJAR

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“…The results demonstrated a high prevalence of H. pylori virulent genotypes in the Cuban patient population, and the vac As1 allele, cag A gene, and iceA2 allele were the most prevalent (72.0%, 56.0%, and 57.3%, respectively). Alleles from the m‐region showed a similar frequency to s1a and s1b subtypes …”

Section: Prevalence Of Virulence Factors and Associations With Clinicmentioning

confidence: 85%

“…Alleles from the m-region showed a similar frequency to s1a and s1b subtypes. 25 The prevalence of H. pylori as well as non-H. pylori Helicobacters was analyzed in Venezuela by enrolling 71 dyspeptic patients from an urban, and 39 from a rural area. 26 The presence of H. pylori was based on amplification of 16S rRNA, glmM, and ureA genes in 55.0% of patients from urban and 87.2% from rural populations.…”

Section: Prevalence Of Virulence Factors and Associations With Clinmentioning

confidence: 99%

Epidemiology of Helicobacter pylori infection

2016

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This review of recent publications related to the epidemiology of Helicobacter pylori highlights the origin of the infection, its changing prevalence, transmission, and outcome. A number of studies have addressed the ancestor roots of the bacteria, and the first genomewide analysis of bacterial strains suggests that its coexistence with humans is more ancient than previously thought. As opposed to the generally declining prevalence of H. pylori (including China and Japan), in Sweden, the prevalence of atrophic gastritis in the young population has risen. The prevalence of the infection remains high in the indigenous populations of the Arctic regions, and reinfection rates are high. A high prevalence is permanently found in the Siberian regions of Russia as well. Several studies, some of which used multiplex serology, addressed prevalence of and risks associated with various H. pylori serotypes, thereby enabling more precise risk assessment. Transmission of H. pylori was discussed, specifically fecal-oral transmission and the use of well-water and other unpurified water. Finally, the long-term course of H. pylori infection was considered, with an estimated 89% of noncardia gastric cancer cases being attributable to the infection.

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“…Among patients with chronic gastritis, 39.2% were cagA+ (27) . The cagA gene was detected in 42 (56.0%) strains in Cuban patients with upper gastrointestinal diseases (10) .…”

Section: Discussionmentioning

confidence: 99%

“…Additionally, further studies may be performed to correlate different digestive disorders with the presence of various virulence factors, including the iceA protein and the different alleles of vacA gen (10) . …”

Section: Discussionmentioning

confidence: 99%

Correlation between virulence markers of Helicobacter pylori in the oral cavity and gastric biopsies

Medina¹,

Medina

Merino

2017

Arq. Gastroenterol.

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-Background -The clinical outcome of Helicobacter pylori infection has been associated with virulence factors. The presence of these factors is useful as molecular markers in the identification of the high risk for developing severe gastric pathologies. Objective -To correlate the presence of virulence markers cagA and bab2A of H. pylori in oral and gastric biopsy samples. Methods -An observational, prospective, descriptive, and cross-sectional study was carried out between September 2011 and September 2012. Patients suffering dyspepsia with indication for upper gastrointestinal video endoscopy who attended the Gastroenterology Service of the Hospital Dr. Julio C. Perrando were included. Epidemiological investigation was completed. To detect the bacteria and their virulence genes, samples of saliva, dental plaque and gastric biopsy were taken and processed by PCR.Results -Sixty-one patients were selected for this study (30 women and 31 men). H. pylori was detected in 31 gastric biopsies and 31 oral samples.Significant difference between oral and gastric samples was found in cagA genotype. Agreement between oral and gastric genotypes was found in 38.7% of samples from the same patient. Conclusion -This study is the first in provide information about the genotypes of the Argentinean Northeast H. pylori strains. Despite the high prevalence of H. pylori infection, the most of patients had less virulent genotypes in oral cavity and gastric tissue. The cagA/babA2 combination was not frequent in the samples studied. There was not a statistical correlation between the virulence genes and gastroduodenal or oral diseases. Although in some patients the same genotype was found both in oral and gastric samples, it cannot be ensure that they corresponding to the same strain because a DNA sequencing was not performed.

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Prevalence ofHelicobacter pylori vacA,cagA, andiceAGenotypes in Cuban Patients with Upper Gastrointestinal Diseases

Cited by 42 publications

References 39 publications

Helicobacter Pylori Infection in Egyptian Patients With Dyspepsia: Diagnostic, Demographic, Endoscopic and Clinical Characteristics.

Helicobacter Pylori Infection in Egyptian Patients With Dyspepsia: Diagnostic, Demographic, Endoscopic and Clinical Characteristics.

Epidemiology of Helicobacter pylori infection

Correlation between virulence markers of Helicobacter pylori in the oral cavity and gastric biopsies

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