2018
DOI: 10.1155/2018/4809093
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Abstract: H. pylori infection causes peptic ulcer, chronic gastritis, mucosa-associated lymphoid tissue lymphoma, and gastric carcinoma. It has several virulence factors such as cytotoxin-associated gene A(cagA) and the induced by contact with epithelium antigen (iceA). We aimed to explore the relationship between cagA and iceA of H. pylori and gastrointestinal diseases. One hundred and eighteen patients who attended Gastrointestinal Endoscopy Unit at Zagazig University Hospitals, Egypt, were included in this study. Two… Show more

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Cited by 35 publications
(34 citation statements)
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References 36 publications
(50 reference statements)
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“…Furthermore, there was a clear association between iceA 1, iceA 2 and chronic active gastritis (38.5, 34.4%, respectively), although it was not statistically significant. Kadi et al [14], Momenah et al [28], and Abu-Taleb et al [33] were in agreement with our data regarding the correlation of iceA 1 with gastritis and peptic ulcer. Also, numerous studies have shown a similar association between iceA genes and the clinical outcomes [43].…”
Section: Discussionsupporting
confidence: 93%
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“…Furthermore, there was a clear association between iceA 1, iceA 2 and chronic active gastritis (38.5, 34.4%, respectively), although it was not statistically significant. Kadi et al [14], Momenah et al [28], and Abu-Taleb et al [33] were in agreement with our data regarding the correlation of iceA 1 with gastritis and peptic ulcer. Also, numerous studies have shown a similar association between iceA genes and the clinical outcomes [43].…”
Section: Discussionsupporting
confidence: 93%
“…With respect to iceA genotype/subtypes, our results revealed that 42.2% of H. pylori were harboring iceA 1, 32.8% were iceA 2, whereas 3.9% were mixed ( iceA 1/ iceA 2). Similar to our findings Abu-Taleb et al [33] and Sedaghat et al [8] reported iceA gene prevalence rates of 46.29 and 48.6%, respectively. Our results showed a significant association of iceA 1 and iceA 2 genes with gastritis and gastric ulcer ( p -value of 0.026).…”
Section: Discussionsupporting
confidence: 93%
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“…A few further studies also reported the correlation between peptic ulcer and iceA of H. pylori [20,21]. Abu-Taleb et al [22] found iceA1 gene among 30% cases with mixed lesions, 6.25% cases with peptic ulcer, and among 8.3% cases with gastritis, while no case of gastric cancer was found. We also found no case of gastric cancer in cases with iceA gene.…”
Section: Discussionmentioning
confidence: 97%
“…After entering the stomach, H. pylori utilizes its urease enzyme to neutralize the gastric acidity. H. pylori then moves toward the gastric epithelium where it binds to the gastric epithelial cell receptors by its adhesion molecule [14]. Cag A is a strong immunogenic protein and measures the virulence of H. pylori infection.…”
mentioning
confidence: 99%