Prevalence of Human Papillomavirus in Oropharyngeal Cancer: A Multicenter Study in Japan

Hama, Takanori; Tokumaru, Yutaka; Fujisawa, Masato; Yane, Katsunari; Okami, Kenji; Kato, Kengo; Masuda, Mitsuharu; Mineta, Hiroyuki; Nakashima, Torahiko; Sugasawa, Masashi; Sakihama, Naoko; Yoshizaki, Tomokazu; Hanazawa, Toyoyuki; Kato, Hisayuki; Hirano, Shigeru; Imanishi, Yorihisa; Kuratomi, Yuichirou; Otsuki, Naoki; Ota, Ichiro; Sugimoto, Taro; Suzuki, Shinsuke

doi:10.1159/000360991

Cited by 75 publications

(54 citation statements)

References 19 publications

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“…Thus, in this study, experienced pathologists in our hospital defined patients with the immune-positive cell ratio of 25% or more in tumor cells as having p16 positivity, according to previous report (15). In this study, the p16-positive rate was 43.75%, which is in line with previous data (9,20,(22)(23)(24)(25).…”

Section: Discussionsupporting

confidence: 86%

Relationship Between p16 Expression and Prognosis in Patients with Oropharyngeal Cancer Undergoing Surgery

Kida

Terada

Uwa

et al. 2018

In Vivo

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Abstract. Background Among head and neck squamous cell carcinomas (HNSCCs), the incidence of oropharyngeal SCC (OSCC) is increasing compared with carcinomas of other origins, thereby attracting public attention (1, 2). Like other malignancies in the upper gastrointestinal tract, OSCC is attributed to the carcinogenic effects of tobacco and alcohol (3). Prediagnosis cigarette smoking can be a prognostic factor for overall survival (OS) in OSCC patients (4). Therapeutic options for early stage OSCC include both surgery and radiotherapy as single treatment modality, while those for advanced stage include surgery, chemoradiation and chemotherapy (5, 6).On the other hand, in recent years, human papillomavirus (HPV) is known to be involved, in addition to drinking and smoking, in oropharyngeal carcinogenesis (1, 7-10). HPV is the most common sexually transmitted disease. However, the overwhelming majority of patients with HPV clear the infection. A small percentage of patients with HPV develop oncogenic HPV types, especially HPV-16, and consequently, SCCs can develop in such patients. HPV causes more than 5% of malignancies worldwide (1, 7-10). Over 70% of OSCCs are currently thought to be linked to oncogenic HPV infection. Immunohistochemistry for p16 protein is often used as a surrogate marker for oncogenic HPV in the oropharyngeal tissues (11, 12). The clinical profile of patients with HPV-related OSCC differs quite notably from that of non-HPV-related OSCC, and the clinical outcome for HPV-related OSCC is reported to be significantly better due to high sensitivity for radiation therapy (2,7,8).Numerous clinical studies have examined the role of transoral surgical resection (SR) for the treatment of oropharyngeal malignancies and have shown similar clinical outcomes and improved functional outcomes compared with chemoradiation therapies (5, 13). However, the relationship between p16 expression and prognosis in OSCC patients undergoing surgery has not been fully examined. Thus, there is urgent need for elucidating these issues. The aims of this study are therefore to clarify the relationship between p16 expression and prognosis in patients with OSCC undergoing surgery. 927

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Section: Discussionsupporting

confidence: 86%

Relationship Between p16 Expression and Prognosis in Patients with Oropharyngeal Cancer Undergoing Surgery

Kida

Terada

Uwa

et al. 2018

In Vivo

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“…For example, almost all cases of HPV-positive HNC (1) are found to originate in the oropharynx, particularly in the palatine and lingual tonsils, (2) are not associated with smoking or drinking, and (3) are more common in comparatively young age groups [3][4][5][6] . Additionally, the primary tumour is discovered comparatively early or while it is still small, although in many cases it has already progressed to cervical LN metastasis, and these LN lesions frequently cause cystic changes [19] .…”

Section: Discussionmentioning

confidence: 99%

The Presence of HPV DNA in Neck Lymph Node Metastasis Correlates with Improved Overall Survival of Patients with Oropharyngeal Cancer Undergoing Surgical Treatment

Shimura

Hama²,

Suda³

et al. 2016

Oncology

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Background: Few studies have addressed how human papilloma virus (HPV) infection in oropharyngeal squamous cell carcinoma (OPSCC) affects the outcome of surgical therapy; furthermore, the relationship between the presence of HPV DNA and neck lymph node (LN) metastasis has not been well established. Methods: A total of 65 patients who underwent surgery as a first-line therapy for OPSCC were enrolled in this study. In HPV-positive patients, the presence of HPV DNA in metastatic neck LN lesions was evaluated. Results: The HPV-positive patients had significantly better overall survival than the HPV-negative patients (log-rank test, p = 0.04), whereas HPV infection status did not significantly affect disease-free survival (log-rank test, p = 0.65). In all of the HPV-positive OPSCC patients who developed cervical LN metastasis, the same HPV DNA type was found in both the primary tumour and the metastases. Conclusions: The present results suggest that HPV infection is a determining factor for good prognosis in patients undergoing first-line surgical therapy for OPSCC.

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“…Using PCR-based methods, Mineta et al showed that 23 % of all HNSCC showed HPV positivity and OPSCC was the most common (54 %) site [39]. The incidence of HPV-related OPSCC has been increasing year by year, from 30 % to 54 % [16,[40][41][42]. The Osaka University reported the trend of HPV infection incidence in tonsillar and base of tongue carcinomas.…”

Section: Prevalence Of Hpv In Hnsccmentioning

confidence: 99%

“…HPV 16 is associated with the majority of OPSCCs in the United States, Europe, and Japan [6,7,11,15,16]. Indeed, a good amount of evidence has been accumulated suggesting that HPV-related OPSCC has special characteristics distinct from OPSCC not related to HPV.…”

Section: Introductionmentioning

confidence: 99%

Clinical features and treatment strategy for HPV-related oropharyngeal cancer

Okami

2016

Int J Clin Oncol

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Among head and neck squamous cell carcinoma (HNSCC), the incidence of oropharyngeal SCC (OPSCC) is increasing in contrast to carcinoma with origin in other subsites. Human papillomavirus (HPV) is now recognized as a significant risk factor of the carcinogenesis of OPSCC. The HPV-related OPSCC patients tend to be relatively young, less exposed to tobacco and alcohol, and have a relatively high socioeconomic status and education level, which is distinct from HPV-unrelated classical OPSCC. The neck metastases tend to be aggressive and cystic. The better response to treatment resulting in improved prognosis of HPV-related OPSCC led to reconsidering the clinical staging and treatment approaches. Clinical trials of treatment deintensification to reduce the acute and late toxicity without compromising efficacy have been conducted. This review of HPV-related OPSCC focuses on current and generally accepted facts regarding the biology, epidemiology, and therapeutic strategy of this new disease entity.

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Prevalence of Human Papillomavirus in Oropharyngeal Cancer: A Multicenter Study in Japan

Cited by 75 publications

References 19 publications

Relationship Between p16 Expression and Prognosis in Patients with Oropharyngeal Cancer Undergoing Surgery

Relationship Between p16 Expression and Prognosis in Patients with Oropharyngeal Cancer Undergoing Surgery

The Presence of HPV DNA in Neck Lymph Node Metastasis Correlates with Improved Overall Survival of Patients with Oropharyngeal Cancer Undergoing Surgical Treatment

Clinical features and treatment strategy for HPV-related oropharyngeal cancer

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