Prevalence of Human Papilloma Virus Infection in Bladder Cancer: A Systematic Review

Muresu, Narcisa; Lorenzo, Biagio Di; Saderi, Laura; Sechi, Illari; Rio, Arcadia Del; Piana, Andrea; Sotgiu, Giovanni

doi:10.3390/diagnostics12071759

Cited by 11 publications

(20 citation statements)

References 63 publications

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“…14 On the other hand, two recent meta-analyses have shown conflicting results, one showing that HPV infection is not associated with bladder cancer (OR: 2.077, 95% CI: 0.940-4.587), 6 while the other reported a significant association between HPV infection and bladder cancer (OR: 7.8406, 95% CI: 4.343-14.16). 15 However, condyloma acuminatum can develop into SCC. Samarska et al summarized 38 patients with condyloma acuminatum of the bladder, 17 of whom had SCC concurrently with condyloma acuminatum or within a year of diagnosis.…”

Section: Discussionmentioning

confidence: 99%

“…The high affinity of HPV to differentiating squamous epithelium and the ability to evade immune responses may explain the mechanism of cancer development in the bladder epithelium. 15 A meta-analysis demonstrated that the association between HPV and bladder cancer risk was highest among Asians (OR 6.289; 95% CI 2.167-18.250). 6 In addition to geographical factors, age is also a risk factor for HPV-related cancer.…”

Section: Discussionmentioning

confidence: 99%

“…A previous meta‐analysis showed a significantly high association between HPV infection and bladder cancer, with HPV‐16 being the most prevalent genotype in bladder cancer 14 . On the other hand, two recent meta‐analyses have shown conflicting results, one showing that HPV infection is not associated with bladder cancer (OR: 2.077, 95% CI: 0.940–4.587), 6 while the other reported a significant association between HPV infection and bladder cancer (OR: 7.8406, 95% CI: 4.343–14.16) 15 …”

Section: Discussionmentioning

confidence: 99%

“…Condyloma acuminatum of the bladder is associated with SCC of the bladder, regardless of the HPV subtype. The high affinity of HPV to differentiating squamous epithelium and the ability to evade immune responses may explain the mechanism of cancer development in the bladder epithelium 15 …”

Section: Discussionmentioning

confidence: 99%

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A case of condyloma acuminatum of the bladder concurrently diagnosed with urothelial carcinoma

Tsuru,

Nakamura,

Izumi

et al. 2023

IJU Case Reports

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IntroductionCondyloma acuminatum usually occurs in the external genitalia and rarely in the bladder mucosa. Here, we report a case of condyloma acuminatum of the bladder that was detected concurrently with urothelial carcinoma.Case presentationA 42‐year‐old man was referred to our urology department with positive urine cytology for urothelial carcinoma. Cystoscopy revealed a broad‐base nonpapillary bladder tumor. The patient underwent a transurethral resection of the bladder tumor. Pathological examination revealed urothelial carcinoma, high‐grade pT1, and concurrent resection of condyloma acuminatum. DNA was extracted from the paraffin‐embedded transurethral resection of the bladder tumor tissue specimens. HPV11 was detected in condylomas by PCR and in situ hybridization, whereas HPV was not detected in urothelial carcinomas.ConclusionWe report a rare case of condyloma acuminatum of the bladder that was concurrently diagnosed with urothelial carcinoma from the same site.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

A case of condyloma acuminatum of the bladder concurrently diagnosed with urothelial carcinoma

Tsuru,

Nakamura,

Izumi

et al. 2023

IJU Case Reports

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“…Вместе с тем появились публикации, указывающие на влияние ВПЧ на течение РМП. Так, результаты опубликованного в 2022 г. метаанализа демонстрируют ухудшение прогноза течения РМП у ВПЧ-инфицированных пациентов [15], в другой публикации указана определенная этиологическая роль ВПЧ-инфицирования в развитии РМП [16]. В определенной степени сходное мнение высказывает другая группа исследователей [17].…”

Section: Introductionunclassified

Genetic and epigenetic characteristics of non-muscle invasive and muscle invasive bladder cancer in patients infected by human papillomavirus: literature review

et al. 2023

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Infectious diseases and chronic inflammation are important risk factors for the development of malignant tumors in humans. One of the key infectious agents involved in human oncogenesis is the human papillomavirus (HPV). Non-muscle invasive bladder cancer is defined as a superficial neoplasia limited to the mucosa, aggravated by recurrence in 80 % of cases and progression in 30 % of cases. The development of this disease is associated with the influence of various carcinogenic agents, including HPV. Currently, a direct relationship has been revealed between the presence of viral DNA in the tumor tissue of the bladder and markers of proliferative activity, angiogenesis, and apoptosis factors. More and more researchers believe in the involvement of the virus in the development of recurrent forms of bladder cancer and the emergence of its invasive/poorly differentiated forms. Improving the diagnosis and postoperative monitoring of non-muscle invasive and muscle invasive bladder cancer is not possible without the improvement of minimally invasive molecular methods, which requires an understanding of the molecular mechanisms of HPV-associated carcinogenesis.Therefore, this review focuses on the analysis of the molecular mechanisms of HPV effect on progression of non-muscle invasive and muscle invasive bladder cancer. The features of miRNA expression in patients with papillomavirus infection of high oncogenic risk types and non-muscle invasive or muscle invasive bladder cancer are considered in detail. In particular, the role of miR-34а, -218, -20a, -424, -200a, -205-5p, -944, -100, -99a, -202, -30a, -145-5p, -195 and -199a-5 is described in the development and progression of bladder cancer. The mechanisms of disruption in the functioning of key cell signaling pathways during HPV integration in patients with bladder cancer, including changes in gene copy number and methylation level, are also considered.However, the number of HPV-positive tumor specimens that have been comprehensively analyzed using genome-wide studies in the literature remains small. Larger patient cohorts would be useful to further refine HPV-associated integration events and genomic changes, as well as to study clinical manifestations of the consequences of these alterations. Further research on the clinical implications of the observed genomic changes is needed to accurately stratify patients for targeted therapy, radiation and chemotherapy.

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HPV-positive clinically advanced squamous cell carcinoma of the urinary bladder (aBSCC): A comprehensive genomic profiling (CGP) study

Ghelani,

Zerdan,

Jacob

et al. 2023

Urologic Oncology: Seminars and Original Investigations

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Prevalence of Human Papilloma Virus Infection in Bladder Cancer: A Systematic Review

Cited by 11 publications

References 63 publications

A case of condyloma acuminatum of the bladder concurrently diagnosed with urothelial carcinoma

A case of condyloma acuminatum of the bladder concurrently diagnosed with urothelial carcinoma

Genetic and epigenetic characteristics of non-muscle invasive and muscle invasive bladder cancer in patients infected by human papillomavirus: literature review

HPV-positive clinically advanced squamous cell carcinoma of the urinary bladder (aBSCC): A comprehensive genomic profiling (CGP) study

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