Prevalence of HLA-B27 in the general population and in patients with axial spondyloarthritis in Saudi Arabia

Omair, Mohammed A.; AlDuraibi, Fatmah K.; Bedaiwi, Mohamed; Abdulaziz, Sultana; Husain, Waleed; Dessougi, Maha; Al-Humaidan, Hind; Khabbaz, Hana J Al; Alahmadi, Ibrahim; Omair, Maha A.; Saleh, Salman Al; Alismael, Khalid; Awwami, Moheeb Al

doi:10.1007/s10067-017-3655-0

Cited by 18 publications

(21 citation statements)

References 23 publications

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“…However, we searched eligible studies update to November 2016 and our paper has been online on May 2017. But the study reported by Omair et al was Epub ahead of print on July, 2017, so we do not agree the point of this letter [3].…”

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confidence: 60%

Reply to “Association of HLA-B27 and its subtypes with ankylosing spondylitis and clinical manifestations of ankylosing spondylitis in different HLA-B27 subtypes: comment on the article by Lin et al.”

Lin

Gong

2017

Rheumatol Int

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on different races and ethnicities. We agree to this point and re-analyze the relationship of HLA-B27 and clinical characters in AS patients. Based on different races, the results of our analyses showed that there was a positive relation between HLA-B27 and sex [East Asia: RR (95% CI) = 1.05 (1.00, 1.10), P = 0.033], family history [East Asia: RR (95% CI) = 1.09 (1.05, 1.13), P < 0.001; Southwest Asia: RR (95% CI) = 1.69 (1.30, 2.22), P < 0.001], uveitis [East Asia: RR (95% CI) = 1.05 (1.01, 1.09), P = 0.008; Southwest Asia: RR (95% CI) = 1.46 (1.08, 1.96), P = 0.013] and peripheral joint involvement [Southwest Asia: RR (95% CI) = 1.74 (1.30, 2.34), P < 0.001]. However, as the limitations of eligible studies, it is difficult to conduct subgroup analysis for the relationships of HLA-B27 subtypes and clinical parameters in AS patients. Therefore, more relevant studies should be conducted to identify these results.Thanks for the advices suggested from this letter. Best regards, Dr. Lin.

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confidence: 60%

Reply to “Association of HLA-B27 and its subtypes with ankylosing spondylitis and clinical manifestations of ankylosing spondylitis in different HLA-B27 subtypes: comment on the article by Lin et al.”

Lin

Gong

2017

Rheumatol Int

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“…Also HLA B27 positivity rates in nraxSpA disease in different ethnic groups are highly variable. Omair et all showed that HLA B27 positivity was found to be 25,9 % in nraxSpA patients in Saudi Arabia [26]. Another study conducted in Sri Lanka, the HLA B27positivity in Spondyloarthritis patients was found to be 22.8 % [27].…”

Section: Discussionmentioning

confidence: 94%

Comparison of Clinical and Demographic Features of FMF with Sacroiliitis Patients with FMF and Axial Spondyloarthritis Patients

Bayrak

Erten

Küçükşahin

et al. 2020

Aktuelle Rheumatologie

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Objectives Familial Mediterranean fever (FMF) is the most common autoinflammatory disease, characterised by recurrent fever and serositis attacks lasting 1–3 days. Musculoskeletal involvement is the second most common manifestation in FMF patients. Sacroiliitis is another musculoskeletal involvement; as there is no spinal involvement, this is called FMF with sacroiliitis. This study was designed to investigate the clinical, demographic and genetic features of FMF in sacroiliitis patients and to compare them with axial SpA and FMF patients. Materials and Methods Forty-two FMF with sacroiliitis patients, 100 axial SpA patients and 100 FMF patients were recruited, and their demographic characteristics were recorded. Evidence of sacroiliitis was confirmed by sacroiliac joint MRI, and patients were examined for arthritis and enthesitis. MEFV gene mutations, HLA B27 positivity and ESR and CRP results were compared. Results In the FMF with sacroiliitis group, the M694V mutation was detected in 59.5% of patients. FMF with sacroiliitis patients were largely (83.3%) negative for HLA B27. The frequency of enthesitis was similar between FMF with sacroiliitis and axial SpA, and the frequency of arthritis was higher in axial SpA patients. Inflammatory markers (ESR and CRP) were statistically higher in FMF with sacroiliitis patients compared with axial SpA and FMF patients. Conclusion When all three groups were compared, the M694V mutation was more common, HLA B27 was largely negative and inflammatory markers were higher in the FMF with sacroiliitis group. FMF should be included in the differential diagnosis of sacroiliitis for managing treatment correctly and preventing complications.

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“…The human leukocyte antigens (HLA) B27 gene, the natural function of which is to present intracellular peptides to cytotoxic T lymphocytes, is strongly associated with SpA ( 20 ). The prevalence of HLA-B27 in the general population ranges from around 2 to 6% ( 21 , 22 ), while it reaches 94% in AS ( 20 ). However, in other phenotypes of the SpA spectrum, HLA-B27 can be detected in lower proportions ranging from 30 to 75% ( 20 ).…”

Section: Criteria For Fm and Spa: State Of The Artmentioning

confidence: 99%

The Impact of Fibromyalgia in Spondyloarthritis: From Classification Criteria to Outcome Measures

et al. 2018

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The term spondyloarthritis (SpA) encompasses a broad clinical spectrum characterized by chronic inflammatory conditions affecting the sacroiliac joints, the spine but also peripheral joints and tendons and being additionally associated with the involvement of organs, such as bowel, eye and skin (1). Musculoskeletal pain is a key symptom in SpA. However, although low back pain and/or joint pain are characteristic for SpA, undifferentiated pain at different enthesial sites may also be a concomitant or even the first clinical presentation in some patients (2). In addition, fatigue is another important symptom often reported by patients with SpA, which substantially affects the quality of life (QoL) (3). Fibromyalgia (FM) is the most common diagnosis in patients complaining of chronic diffuse pain with fatigue and may occur alone or in association with chronic inflammatory diseases (4). The prevalence of FM ranges from 2 to 8% in the general population and it can reach up to over 50% in patients with other rheumatic and musculoskeletal diseases (RMDs) (5–7). FM has been identified as the most disabling RMD, based on the patients' perception that their medical condition is not properly recognized (8). This is also due to the poor knowledge about its pathogenesis, and therefore the lack of reliable biomarkers reveals a major unmet need requiring to be addressed in further research studies. Over the last decade, an increasing body of evidence described the impact of FM in SpA highlighting the pitfalls for correct classification, appropriate differential diagnosis and assessment of outcome measures in both conditions. The purpose of this review is to provide an overview of currently available data with regard to the coexistence and reciprocal features of FM and SpA.

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Prevalence of HLA-B27 in the general population and in patients with axial spondyloarthritis in Saudi Arabia

Cited by 18 publications

References 23 publications

Reply to “Association of HLA-B27 and its subtypes with ankylosing spondylitis and clinical manifestations of ankylosing spondylitis in different HLA-B27 subtypes: comment on the article by Lin et al.”

Reply to “Association of HLA-B27 and its subtypes with ankylosing spondylitis and clinical manifestations of ankylosing spondylitis in different HLA-B27 subtypes: comment on the article by Lin et al.”

Comparison of Clinical and Demographic Features of FMF with Sacroiliitis Patients with FMF and Axial Spondyloarthritis Patients

The Impact of Fibromyalgia in Spondyloarthritis: From Classification Criteria to Outcome Measures

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