“…In the Phase 2 study, which involved four separate doses of eluxadoline (5, 25, 100, or 200 mg) or placebo given to 807 IBS-D patients twice daily over 12 weeks, adverse events (AEs) were similar for placebo and the lower three doses of the study medication (5,25, and 100 mg). At least one treatment-related AE was identified in 49% of those randomized to placebo compared with 44%, 51%, and 44% randomized to the 5-, 25-, or 100-mg doses, respectively (n.s.).…”