Prevalence of dementia and major dementia subtypes in Spanish populations: A reanalysis of dementia prevalence surveys, 1990-2008

Pedro‐Cuesta, Jesús de; Virués‐Ortega, Javier; Vega, Saturio; Seijo-Martínez, Manuel; Saz, Pedro; Rodríguez, Felipe; Rodríguez-Laso, Ángel; Rizzoli, René; Heras, Susana Pérez de las; Mateos, Raimundo; Martinez‐Martín, Pablo; Manubens, J.M.; Mahíllo‐Fernández, Ignacio; López-Pousa, Secundino; Lobo, Antonio; Reglà, Jordi Llinàs; Gascón, Jordi; Garcı́a, Francisco; Fernández-Martı́nez, Manuel; Boix, Raquel; Bermejo‐Pareja, Félix; Bergareche, Alberto; Benito‐León, Julián; Arce, Ana de; Barrio, José Luis del

doi:10.1186/1471-2377-9-55

Cited by 125 publications

(91 citation statements)

References 34 publications

(31 reference statements)

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“…Consistent with previous findings, we show that ageing per se constitutes a considerable oxidative insult in the brain. However, our data also suggest that a long-term poor vitamin C status does not accelerate this process.The overall prevalence of age-associated brain disorders such as Alzheimer's disease, Parkinsonism and dementia is increasing in the Western World as a natural consequence of the improved average lifetime expectancy [1][2][3]. This has prompted investigations into the underlying mechanisms associated with ageing to become a growing field of interest.…”

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confidence: 99%

Chronic Vitamin C Deficiency does not Accelerate Oxidative Stress in Ageing Brains of Guinea Pigs

Tveden‐Nyborg

Hasselholt

Miyashita

et al. 2012

Basic Clin Pharma Tox

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Increased oxidative stress in the brain has consistently been implied in ageing and in several degenerative brain disorders. Acting as a pivotal antioxidant in the brain, vitamin C is preferentially retained during deficiency and may play an essential role in neuroprotection during ageing. Thus, a lack of vitamin C could be associated with an increase in redox imbalance in the ageing brain. The present study compared oxidative stress of ageing to that of a long-term non-scorbutic vitamin C deficiency in guinea pigs. Adults (3-9 months old) were compared to old (36-42 months old) animals during a 6-month dietary intervention by assessing vitamin C transport and redox homoeostasis in the brain. In contrast to our hypothesis, chronic vitamin C deficiency did not affect the measured markers of oxidative stress in the brains of adult and aged animals. However, aged animals generally showed increased lipid oxidation (p < 0.001), decreased glutathione (p < 0.05), increased p53 mRNA expression (p < 0.01) and somewhat elevated DNA oxidation (p = 0.08) compared to adult counterparts irrespective of dietary vitamin C intake. Increased mRNA expression of sod1 (p < 0.05) and svct2 (p = 0.05) was observed in aged animals together with increased superoxide dismutase activity (p < 0.01) and cerebrospinal fluid vitamin C status (p < 0.001) suggesting a compensatory effort that did not counterbalance the effects of ageing. Essentially, no effects of age were observed in the liver demonstrating the brain's unique susceptibility to redox imbalance. Consistent with previous findings, we show that ageing per se constitutes a considerable oxidative insult in the brain. However, our data also suggest that a long-term poor vitamin C status does not accelerate this process.The overall prevalence of age-associated brain disorders such as Alzheimer's disease, Parkinsonism and dementia is increasing in the Western World as a natural consequence of the improved average lifetime expectancy [1][2][3]. This has prompted investigations into the underlying mechanisms associated with ageing to become a growing field of interest. One of the areas receiving particular attention and subject to debate is the putative relationship between oxidative stress, the intake of different nutritional factors -such as antioxidantsand the development and prevention of age-related disorders [4]. Increases in cellular reactive oxygen species (ROS) has consistently been reported during ageing [5]. The increase in ROS is reflected by a decreased gene transcription resulting in cellular stress and oxidative DNA damage -as seen in the brain [6] -and oxidative mitochondrial damage followed by mitochondrial dysfunction [7,8]. Furthermore, DNA repair mechanisms are reduced adding further to the harmful consequences of the oxidative damage in the cell [9].In the brain, vitamin C (ascorbate/ASC) plays a pivotal role in maintaining redox homoeostasis and has additional functions, that is, reducing the risk of neuronal damage because of excess dopamine and glutamate...

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confidence: 99%

Chronic Vitamin C Deficiency does not Accelerate Oxidative Stress in Ageing Brains of Guinea Pigs

Tveden‐Nyborg

Hasselholt

Miyashita

et al. 2012

Basic Clin Pharma Tox

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“…Según la Organización Mundial de la Salud (OMS, 2016) en el mundo hay unos 47,5 millones de personas que padecen demencia y cada año se registran 7,7 millones de nuevos casos. En España hay alrededor de 600.000 personas que presentan demencia y cerca de 400.000 con enfermedad de Alzheimer (de Pedro-Cuesta et al, 2009).…”

Section: Introductionunclassified

Las artes visuales en personas con demencia: revisión sistemática

Badía

2017

Arte Individ. Soc.

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Resumen. La demencia es una condición de salud progresiva, que afecta a un número creciente de personas, caracterizada por el deterioro cognitivo y por la presencia de síntomas neuropsiquiátricos que limitan las actividades de la vida diaria y disminuyen la calidad de vida de la persona. Esta revisión sistemática tiene como objetivo analizar las investigaciones relacionadas con el impacto que tienen las intervenciones en artes visuales en la salud y el bienestar de las personas con demencias. Se ha realizado la revisión utilizando las bases de datos Medline, PsycINFO y Cinahl. De 84 publicaciones encontradas, 18 cumplieron los criterios de inclusión. En los resultados destaca la relevancia actual de la investigación sobre la intervención en artes visuales en la demencia, pero los estudios incluían muestras pequeñas y mostraban importantes debilidades metodológicas. A pesar de todo, la literatura actual sugiere que con los apoyos adecuados las personas con demencia pueden producir y apreciar el arte visual, y mejorar la percepción de bienestar físico y emocional. Palabras clave: Artes visuales; terapia del arte; galerías de arte; demencia; enfermedad de Alzheimer.[en] Visual arts in people with dementia: a systematic review Abstract. Dementia is a progressive health condition, affecting an increasing number of people, characterised by the cognitive impairment and the presence of neuropsychiatric symptoms that limit daily life and diminish the quality of life of the person. The goal of this systematic review is to analyse those investigations related to the impact of visual arts interventions on the health and well-being of people with dementia. This review has been done using Medline, PsycINFO and Cinalh databases. Out of 84 publications found, 18 met the inclusion criteria. The results highlight the current relevance of research on visual arts intervention in dementia, but the studies included small samples and showed important methodological weaknesses. Nevertheless, current literature suggests that with adequate supports people with dementia can produce and appreciate visual art, and improve the perception of physical and emotional well-being.

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“…El estudio llevado a cabo por Lobo (2011) en España con un seguimiento de una co horte de 4057 individuos cognitivamente intactos mayores de 55 años de edad que viven en Zaragoza, muestra que la tasa de incidencia de la demencia fue de 8,6 por 1000 y la de EA de 5,4 por 1000. También De Pedro-Cuesta et al (2009) llevaron a cabo un estudio, centrándose en el centro y noreste de España, en el que se pretendía conocer en qué grado afecta a la población las demencias más frecuentes en España. Su conclusión fue que la prevalencia de la demencia y la enfermedad de Alzheimer en las zonas citadas, aumentan con la edad y es mayor en mujeres, siendo la demencia más frecuente el Alzheimer.…”

Section: Introductionunclassified

Música y palabra contra el alzheimer

Vernia

Martí

2017

Arte Individ. Soc.

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Resumen. Este artículo muestra los resultados obtenidos en un proyecto llevado a cabo entre una residencia para personas mayores y la Universidad Jaume I de Castellón nacido a raíz de un premio convocado por ambas instituciones. Se llevó a cabo la implementación de diferentes actividades con el objetivo de incidir positivamente en la memoria y la calidad de vida de las personas residentes. Estas actividades estuvieron fundamentadas, por una parte, por la metodología Dalcroze "la Euritmia" y por otra parte, por las "Historias de Vida". La aplicación corrió a cargo del profesorado de la Universidad mencionada y bajo la supervisión de una psicóloga externa, quien seleccionó los cuestionarios para pasar a la muestra y, a través del programa SPSS gestionó los resultados. El proyecto se llevó a lo largo de 28 sesiones, que aunque supone una escasa temporalidad, atendiendo a los resultados obtenidos nos llevan a plantear la continuidad del proyecto. Cabe destacar la mejora en la calidad de vida de los participantes y su disposición a seguir colaborando. Palabras clave: Euritmia; historias de vida; Alzheimer; calidad de vida personas mayores.[en] Music and word against Alzheimer Abstract. The aim of this article is to show the results obtained in a project between a nursing home and the Jaume I University in Castellón. It was born from a proposed prize of both establishments. Some activities were implemented in order to contribute positively to the memory and the quality of life of the residents. On the one hand, these activities were based on Dalcroze Method: the Eurhythmics. On the other hand they are based on life histories. The appliance was implemented by teachers of the mentioned University and supervised by an external psychologist. She chose the questionnaires to be taken and, through the SPSS programme, managed the results. Despite the limited time, the project lasted 28 sessions and thanks to the success of its results we propose the continuity of the project. It is worth stressing the improvements in the participants' standards of living and their disposal to continue working together. Keywords: Eurhythmics; life histories; Alzheimer; quality of life for the elderly. Sumario

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Prevalence of dementia and major dementia subtypes in Spanish populations: A reanalysis of dementia prevalence surveys, 1990-2008

Cited by 125 publications

References 34 publications

Chronic Vitamin C Deficiency does not Accelerate Oxidative Stress in Ageing Brains of Guinea Pigs

Chronic Vitamin C Deficiency does not Accelerate Oxidative Stress in Ageing Brains of Guinea Pigs

Las artes visuales en personas con demencia: revisión sistemática

Música y palabra contra el alzheimer

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