Prevalence of Chronic Pain and High-Impact Chronic Pain Among Adults — United States, 2016

Dahlhamer, James M.; Lucas, Jacqueline W.; Zelaya, Carla; Nahin, Richard L.; Mackey, Sean; DeBar, Lynn; Kerns, Robert D.; Korff, Michael Von; Porter, Linda; Helmick, Charles G.

doi:10.15585/mmwr.mm6736a2

Cited by 1,827 publications

(1,406 citation statements)

References 5 publications

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“…It represents a significant challenge to individuals and their families, as well as healthcare providers and payers. Surveys estimate that around one in five adults report chronic pain . Some studies indicate that the prevalence increases with age and is rising overall .…”

Section: Introductionmentioning

confidence: 99%

Pain relief and improvement in quality of life with 10 kHz SCS therapy: Summary of clinical evidence

et al. 2020

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Objective Chronic pain is a prevalent condition which has a significant effect on the lives of those it impacts. High‐frequency 10 kHz spinal cord stimulation (10 kHz SCS) has been shown to provide paresthesia‐free pain relief for a wide variety of pain indications. This article summarizes the current and emerging data as they relate to the clinical use of the therapy in various pain syndromes. Methods A literature search was conducted using the PubMed electronic database using keywords related to 10 kHz SCS. The database was queried from 2013 to May 2019. Articles reporting clinical studies that included human subjects permanently treated with 10 kHz SCS (Senza® system) were included in the review. Recent and relevant conference proceedings known to the authors were also included. Results The selected literature demonstrated significant evidence for the efficacy of 10 kHz SCS in treating chronic back and leg pain (CBLP), including a randomized, controlled trial as well as prospective and retrospective studies. One‐year follow‐up responder rates (pain relief ≥50%) ranged from 60% to 80%. Other studies and case series showed promising outcomes in specific conditions, including nonsurgical refractory back pain, neuropathic limb pain, complex regional pain syndrome, chronic widespread pain, chronic pelvic pain, and intractable headache. Subgroup analyses also pointed toward the potential of 10 kHz SCS being successful when low‐frequency SCS has failed. The vast majority of these studies reported improved quality of life (QOL) metrics and/or reduced opioid consumption. Conclusions Level I evidence already exists for the efficacy of 10 kHz SCS in treating CBLP, supported by real‐world clinical experience. Other studies demonstrate the potential of the therapy across a range of chronic pain etiologies, although larger confirmatory studies are recommended. Overall, the literature suggests that the therapy is associated with improved QOL as well as reduced opioid consumption.

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Section: Introductionmentioning

confidence: 99%

Pain relief and improvement in quality of life with 10 kHz SCS therapy: Summary of clinical evidence

et al. 2020

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“…Chronic pain is a common condition that affects patients’ physical and mental health, and greater pain severity is correlated with worse patient outcomes . The Centers for Disease Control and Prevention (CDC) estimated that 20% of adults in the United States were affected by chronic pain in 2016, which translates to about 50 million Americans, and the World Health Organization has reported worldwide estimates of prevalence to range from 5% to 33%, with an average of 21.5% . Surveys have found that patients with chronic pain often report incomplete pain relief from available treatments, and a significant proportion of patients report impacts on their general activity, mood, and enjoyment of life, as well as their ability to walk, work, or sleep …”

Section: Introductionmentioning

confidence: 99%

Opioid‐sparing effects of 10 kHz spinal cord stimulation: a review of clinical evidence

Al‐Kaisy

Buyten

Amirdelfan³

et al. 2019

Annals of the New York Academy of Sciences

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Chronic pain is a common condition that affects the physical, emotional, and mental well‐being of patients and can significantly diminish their quality of life. Due to growing concerns about the substantial risks of long‐term opioid use, both governmental agencies and professional societies have recommended prioritizing the use of nonpharmacologic treatments, when suitable, in order to reduce or eliminate the need for opioid use. The use of 10 kHz spinal cord stimulation (10 kHz SCS) is one such nonpharmacologic alternative for the treatment of chronic, intractable pain of the trunk and limbs. This review examines published clinical data regarding the efficacy of 10 kHz SCS for decreasing chronic pain in patients and its potential to reduce or eliminate opioid usage. Multiple prospective and retrospective studies in patients with intractable pain demonstrated that 10 kHz SCS treatment provided ≥50% pain relief in >70% patients after at least 1 year of treatment. Pain relief with 10 kHz SCS therapy ranged from 54% to 87% in the studies. More importantly, the mean daily dose of opioids required by patients in these studies was reduced after 10 kHz SCS treatment, and on average over 60% patients in studies either reduced or eliminated opioids at the last follow‐up.

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“…Prior reviews on the prevalence of chronic pain in this population vary widely and, depending on the population surveyed and the time since diagnosis, report rates ranging from <5% to 40%, with most studies focusing on the early phase of survivorship . A recently published article in Morbidity and Mortality Weekly Report reported that an estimated 20.4% of all US adults in the general population are living with chronic pain, with higher incidences in elderly individuals and in women . Cancer survivors are likely at increased risk for chronic pain because of their diagnosis and associated treatments; however, there are no comprehensive studies on the prevalence of chronic pain among individuals with a history of cancer and the impact of having chronic pain among cancer survivors.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of chronic pain among cancer survivors in the United States, 2010‐2017

Sanford

Sher

Butler

et al. 2019

Cancer

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Background There are a growing number of cancer survivors in the United States who are at risk for chronic pain due to cancer disease and treatments. The prevalence of chronic pain among cancer survivors has not been comprehensively reported. Methods This study used data from the National Health Interview Survey (2010‐2017) to compare the prevalence of chronic pain between participants with a cancer diagnosis and participants without one. Adjusted odds ratios (AORs) of having chronic pain were assessed by multivariable logistic regression, which included an age (less than the median age vs greater than or equal to the median age) × cancer diagnosis (yes vs no) interaction term. Among cancer survivors, multivariable logistic regression defined the odds of feeling depressed, feeling worried/nervous/anxious, being unable to work, and needing assistance for activities of daily living (ADLs) and instrumental activities of daily living (IADLs). Results Among 115,091 participants, a cancer diagnosis was associated with an increased AOR of chronic pain in comparison with the general population (30.8% vs 15.7%; AOR, 1.48; 95% confidence interval, 1.38‐1.59). Older age was associated with higher odds of chronic pain (P < .001 across all increasing age categories); however, the positive association between older age and chronic pain was seen only in participants without cancer and was not seen in those with a cancer diagnosis (Page×cancer < .001). Among patients reporting a cancer diagnosis, chronic pain was associated with greater odds of feeling depressed, feeling worried/nervous/anxious, being unable to work, and needing assistance with ADLs or IADLs (P < .001 for all). Conclusions Cancer survivors appear to have a high prevalence of chronic pain, which is associated with worse mental, functional, and employment outcomes. Screening and management of chronic pain should be addressed by policymakers to improve cancer survivorship care.

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Prevalence of Chronic Pain and High-Impact Chronic Pain Among Adults — United States, 2016

Cited by 1,827 publications

References 5 publications

Pain relief and improvement in quality of life with 10 kHz SCS therapy: Summary of clinical evidence

Pain relief and improvement in quality of life with 10 kHz SCS therapy: Summary of clinical evidence

Opioid‐sparing effects of 10 kHz spinal cord stimulation: a review of clinical evidence

Prevalence of chronic pain among cancer survivors in the United States, 2010‐2017

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