Prevalence of Chronic Kidney Failure and Associated Factors in Patients Treated by Antiretroviral in the National Teaching Hospital of Cotonou

Dm, Zannou; Vigan, J; Azon-Kouanou, Angèle; Bl, Agboton; Cmb, Houngbe; Houngbe, Fabien

doi:10.4172/2161-0959.1000214

Cited by 2 publications

(5 citation statements)

References 21 publications

(40 reference statements)

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“…In our study, we reported that age greater than 45 years with an OR of 5.5 (p = 0.045) was associated with the occurrence of CKD. Zannou et al [19] In our study, pathological proteinuria was a risk factor for CKD. Zannou et al [19] did not reach the same conclusion in their study in Benin.…”

Section: Discussionsupporting

confidence: 58%

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Antiretroviral Therapeutic Profile in Patients Living with HIV with Chronic Kidney Disease

Tsevi¹,

Bawe²,

Nemi³

et al. 2019

AID

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Chronic Kidney disease (CKD) is one of the important complications during HIV infection. The advent of Highly Active Antiretroviral Therapy (HAART) has significantly improved the prognosis of these patients. This was a descriptive and analytical cross-sectional study of people living with HIV received at the Ambulatory Treatment Center (ATC) of the Department of Infectious Diseases of Sylvanus Olympio University Hospital (CHU-SO). The study period was 6 months from January 1, 2018 to June 30, 2018. A total of 234 patients were enrolled during the study period. The mean age of patients at initiation of treatment was 42.07 ± 9.49 years with an average duration of follow-up under antiretroviral treatment of 5.61 ± 3.22 years. The female sex was predominant (70.09%) and a sex ratio (M/F) of 0.43. Most people living with HIV were mostly classified at clinical stage 2 (30.77) and 3 (31.62%) of WHO at initiation of HAART. The mean CD4 rate was 223.30 ± 143.764 at initiation of HAART and 462.58 ± 202.723 at the time of study. The frequency of CKD was 11.11%. The majority of patients were placed in a fixed combination of Tenofovir/Lamivudine/Efavirenz in a proportion of 81.20% of cases. In univariate analysis shows that age greater than 45 years (p = 0.017). Pathological proteinuria (p = 0.021) were associated with CKD. In multivariate analysis, only age (p = 0.045) and pathological proteinuria (p = 0.035) were significantly associated with CKD.

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Section: Discussionsupporting

confidence: 58%

“…Zannou et al [19] In our study, pathological proteinuria was a risk factor for CKD. Zannou et al [19] did not reach the same conclusion in their study in Benin. Nevertheless countries is the administration of doses that are sometimes not commercially available on the market.…”

Section: Discussionsupporting

confidence: 58%

Antiretroviral Therapeutic Profile in Patients Living with HIV with Chronic Kidney Disease

Tsevi¹,

Bawe²,

Nemi³

et al. 2019

AID

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“…In our study, pathological proteinuria was a risk factor for CKD. Zannou et al [15] did not reach the same conclusion in their study in Benin. Nevertheless, the association of proteinuria with CKD in HIV-infected patients is an indicator of the importance of the care for these patients.…”

Section: Discussionmentioning

confidence: 65%

“…In our study we reported that greater than 45 years with OR of 5.5 (p = 0.017) Open Journal of Nephrology was associated with the occurrence of CKD. Zannou et al [15] .68, p = 0.025). In the USA, Shwartz et al [7] had shown that the presence of hypertension is a high-risk marker for developing CKD [19].…”

Section: Discussionmentioning

confidence: 89%

“…This prevalence is variable according to the studies and this depends on the population studied and the estimation method of the GFR [14]. Zannou found 18.7% of Beninese population of 480 HIV-infected people using the Cockcroft and Gault formula; the middle age was ±9.16 to ±41.4 years old [15]. Elevated creatinine serum (≥15 mg/l) was used during the study in another study; it gives a prevalence of 31.1%…”

Section: Discussionmentioning

confidence: 99%

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Chronic Kidney Disease (CKD) in Patients Living with HIV under Antiretroviral Treatment: Prevalence and Risk Factors

Tsevi¹,

Moukaila²,

Bawe³

et al. 2019

OJNeph

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CKD is one of the major complications when infected by HIV. The surveillance of CKD indicators and control of its determinants in the HIV-infected population in our African communities is essential. This was a descriptive and analytical cross-sectional study of people living with HIV received at the Ambulatory Treatment Center (ATC) at Infectious Diseases department of Sylvanus Olympio University Hospital (CHU-SO). The study period was 6 months-from January 1, 2018 to June 30, 2018-CKD was defined by a clearance below 60 ml/min/1.73 m 2 for at least 3 months. A total of 117 patients were enrolled during the study period. The average age of patients for trial treatment was between 9.49 and 42.0 7 years. The duration of follow-up for antiretroviral treatment was ±3.22 to ±5.64 years. The female gender was predominant (70.09%) with a sex ratio (M/F) of 0.43. Most of people living with HIV were mostly classified at clinical stage 2 (31.03%) and 3 (31.90%) of WHO at initiation of HAART. The main CD4 rate was 223.30 ± 143.764 at initiation of HAART and 462.58 ± 202.723 at the time of the study. The majority of patients were placed in a fixed combination of Tenofovir/Lamivudine/Efavirenz in a proportion of 81.20% cases. CKD was found in 13 patients-that is 11.11% of patients. Univariate analysis shows that age greater than 45 years plus (p = 0.017) and pathological proteinuria (p = 0.021) were associated with CKD. In multivariate analysis, only ages (p = 0.045) and pathological proteinuria (p = 0.035) were significantly associated with CKD. The prevalence of CKD in HIV-infected patients is significant in Togo. The occurrence of proteinuria is linked to the delay in taking antiretroviral therapy.

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Prevalence of Chronic Kidney Failure and Associated Factors in Patients Treated by Antiretroviral in the National Teaching Hospital of Cotonou

Cited by 2 publications

References 21 publications

Antiretroviral Therapeutic Profile in Patients Living with HIV with Chronic Kidney Disease

Antiretroviral Therapeutic Profile in Patients Living with HIV with Chronic Kidney Disease

Chronic Kidney Disease (CKD) in Patients Living with HIV under Antiretroviral Treatment: Prevalence and Risk Factors

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