2017
DOI: 10.1371/journal.pntd.0005244
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Abstract: Chagas disease (CD) affects over six million people and is a leading cause of cardiomyopathy in Latin America. Given recent migration trends, there is a large population at risk in the United States (US). Early stage cardiac involvement from CD usually presents with conduction abnormalities on electrocardiogram (ECG) including right bundle branch block (RBBB), left anterior or posterior fascicular block (LAFB or LPFB, respectively), and rarely, left bundle branch block (LBBB). Identification of disease at this… Show more

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Cited by 35 publications
(26 citation statements)
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“…; Traina et al. ). Chagas disease is also the most prevalent parasitic disease in the Americas, with 100 million people at risk and more than 10,000 deaths per year (Montgomery et al.…”
Section: Genes That Have Been Functionally Studied In Trypanosomatidsmentioning
confidence: 96%
See 1 more Smart Citation
“…; Traina et al. ). Chagas disease is also the most prevalent parasitic disease in the Americas, with 100 million people at risk and more than 10,000 deaths per year (Montgomery et al.…”
Section: Genes That Have Been Functionally Studied In Trypanosomatidsmentioning
confidence: 96%
“…Within trypanosomatids, CRISPR/Cas9 technology was first used to modify the genome of T. cruzi, the causative agent of Chagas disease. This slow-progressing, life-threatening disease affects about 7-8 million people worldwide, mostly in Latin America where the disease is endemic (Forsyth et al 2016;Traina et al 2017). Chagas disease is also the most prevalent parasitic disease in the Americas, with 100 million people at risk and more than 10,000 deaths per year (Montgomery et al 2014).…”
Section: Trypanosoma Cruzimentioning
confidence: 99%
“…The CECD observed an even higher prevalence (7.4%) in a sample of close relatives of previously diagnosed patients [54]. Further, the CECD identified a hidden burden of the disease among Latin American-born patients with nonischemic cardiomyopathy, pacemakers, and electrocardiogram abnormalities [55][56][57]. These studies suggest a significant impact of CD in Los Angeles, where up to 30,000 people may be affected.…”
Section: Californiamentioning
confidence: 98%
“…Chagas disease was discovered more than 100 years ago and remains one of the most significant public health challenges in Latin America 1,2 . The World Health Organization estimates that 8 to 10 million people are infected worldwide and 100 million people are at risk, mostly in Latin America where the disease is endemic [2][3][4][5] .…”
Section: Introductionmentioning
confidence: 99%
“…In past decades, Chagas disease has also been detected in nonendemic countries, a phenomenon linked to population mobility and migratory movements that has led to the globalization of the disease 1,6,7 . As a consequence of global migration 3,8 , more than 300,000 individuals in the United States, 100,000 in Europe, 5,500 in Canada, 3,000 in Japan, and 1,500 in Australia are currently living with Trypanosoma cruzi infection.…”
Section: Introductionmentioning
confidence: 99%