Prevalence of Antibodies to Hantavirus Among Family and Health Care Worker Contacts of Persons With Hantavirus Cardiopulmonary Syndrome: Lack of Evidence for Nosocomial Transmission of Andes Virus to Health Care Workers in Chile

Castillo, Claudia; Villagra, Eliecer; Sanhueza, Ligia; Ferrés, Marcela; Mardones, Jovita; Mertz, Grégory

doi:10.4269/ajtmh.2004.70.302

Cited by 24 publications

(20 citation statements)

References 13 publications

(16 reference statements)

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“…Second, the number of days from exposure to an index case-patient and the onset of symptoms among additional cases ranges from 12 to 27 days ( 7 , 26 ), consistent with the intervals observed in our report. In the 2 cases for which environmental exposure was reported, the estimated incubation period after that exposure exceeded the longest reported incubation range of 42 days for ANDV ( 3 , 11 ). In contrast, in these 2 cases the estimated incubation periods from exposure to a case-patient to onset of symptoms was 13–27 days.…”

Section: Discussionmentioning

confidence: 87%

“…IgM and IgG seroconversion were confirmed 10 days after symptom onset. The person-to-person exposure period for this patient was March 6–20; his possible environmental exposure exceeded the known incubation period for ANDV ( 11 ). Shock and respiratory failure developed, and he required mechanical ventilation and vasopressors but survived.…”

Section: Resultsmentioning

confidence: 93%

“…Although person-to-person transmission in Chile has been epidemiologically documented ( 10 ), nosocomial transmission has not been reported. Seroprevalence studies conducted among health care workers in hospitals in Chile where patients with ANDV infection have been treated have reported that health care workers exhibited ANDV IgG antibody at a proportion similar to that of the general population ( 11 , 12 ). Similarly, a study in the southwestern United States found no evidence of nosocomial transmission of another hantavirus, Sin Nombre virus ( 13 ).…”

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confidence: 99%

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Person-to-Person Household and Nosocomial Transmission of Andes Hantavirus, Southern Chile, 2011

Martínez-Valdebenito¹,

Calvo²,

Vial³

et al. 2014

Emerg. Infect. Dis.

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Section: Discussionmentioning

confidence: 87%

Section: Resultsmentioning

confidence: 93%

mentioning

confidence: 99%

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Person-to-Person Household and Nosocomial Transmission of Andes Hantavirus, Southern Chile, 2011

Martínez-Valdebenito¹,

Calvo²,

Vial³

et al. 2014

Emerg. Infect. Dis.

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“…Prevalence in Venezuela was 1.7% 24 ; in northeastern Argentina, seroprevalence was 6.5% and was statistically significant for rural activity compared to other studies 25 ; while Chile showed a seroprevalence of 1.9% among family members of patients with HPS [25][26][27] . The highest prevalence occurred in Paraguay, with a mean of 42.7%, and the risk of infection was higher among those who lived in rural environments, similar to the present study 21,27 .…”

Section: Conflict Of Interest Referencesmentioning

confidence: 89%

Serosurvey of hantavirus infection in humans in the border region between Brazil and Argentina

Souza

Machado

Figueiredo

et al. 2011

Rev. Soc. Bras. Med. Trop.

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Introduction: According to reports by the Ministry of Health, in the far western region of the State of Santa Catarina, there have been no reports of hantavirus pulmonary syndrome, a zoonotic disease transmitted by feces of infected rodents. A seroepidemiological study of residents of this region, was conducted, with the aim of determining the presence of hantavirus infections. A total of 340 volunteers of both genus, from the towns of Belmonte and Paraíso, were studied. Methods: The serum of these patients was collected and used to detect IgG antibodies against recombinant N protein of Araraquara hantavirus, by ELISA assay. The positive samples were then titrated and confirmed by immunofluorescence assay. Results: This study demonstrated the presence of IgG antibodies against hantavirus N protein in 3.5% of the population. The most frequent occupation was farm worker, 81% had direct and indirect contact with rodents, 91.7% of positive cases were farm workers, indicating that the probable cause of infection occurred during barn cleaning. These antibodies are noteworthy, given that the levels of antibodies were verified in individuals whose contact with hantavirus may have occurred many years ago. Conclusions: This study shows the circulation of hantavirus in the region, a fact that until now, had not reported. All the serum reagents had contact with the pathogen, but did not develop pulmonary and cardiovascular syndrome. It is important to remain alert, because hantavirus is a serious and emerging disease of some relevance. Keywords: Hantavirus. Seroprevalence in Santa Catarina. Morbidity. RESUMO Introdução:De acordo com relatórios do Ministério da Saúde, na região do extremo oeste do Estado de Santa Catarina, não há relatos de síndrome pulmonar por hantavírus, doença zoonótica transmitida por excretas de roedores contaminados. Com a finalidade de demosntrar a infecção por hantavírus, um estudo soroepidemiológico de moradores da região foi realizado. Assim, foi estudado um total de 340 voluntários de ambos os gêneros, dos municípios de Belmonte e Paraíso. Métodos: O soro destes pacientes foi coletado e usado para a detecção de anticorpos IgG contra a proteína N recombinante de hantavírus Araraquara, pelo teste de ELISA. As amostras positivas foram tituladas e confirmadas por imunofluorescência indireta. Resultados: Este estudo demonstrou a presença de anticorpos IgG contra a proteína N hantavírus em 3,5% da população. A ocupação de lavrador foi a mais frequente, e 81% tiveram contato direto e indireto com os roedores, 91,7% dos casos positivos foram os agricultores, a causa provável da infecção foi através da limpeza de celeiros. Estes anticorpos são notáveis, dado que os níveis de anticorpos são encontrados nos indivíduos cujo contato com o hantavírus pode ter ocorrido há muitos anos. Conclusões: Este estudo mostra a circulação de hantavírus na região, um fato que até então não havia relatado, todos os reagentes soro tiveram contato com o patógeno, mas não desenvolveram a síndrome pulmonar e cardiovascu...

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“…Fortunately, none of the persons exposed to the patient reported symptoms consistent with HPS during the incubation period, and none who were tested seroconverted. Seroprevalence surveys in Chile among healthcare worker contacts of patients with HPS caused by the Andes virus showed a prevalence of 0% ( 9 ). A report from Argentina showed that cases due to secondary transmission occurred mostly in non-healthcare workers after prolonged close contact in the prodromal period ( 10 ).…”

mentioning

confidence: 99%

Imported Fatal Hantavirus Pulmonary Syndrome

Reynolds

Galanis

Krajden

et al. 2007

Emerg. Infect. Dis.

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Prevalence of Antibodies to Hantavirus Among Family and Health Care Worker Contacts of Persons With Hantavirus Cardiopulmonary Syndrome: Lack of Evidence for Nosocomial Transmission of Andes Virus to Health Care Workers in Chile

Cited by 24 publications

References 13 publications

Person-to-Person Household and Nosocomial Transmission of Andes Hantavirus, Southern Chile, 2011

Person-to-Person Household and Nosocomial Transmission of Andes Hantavirus, Southern Chile, 2011

Serosurvey of hantavirus infection in humans in the border region between Brazil and Argentina

Imported Fatal Hantavirus Pulmonary Syndrome

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