Prevalence of and Risk Factors for Pterygium in Rural Adult Chinese Populations of the Bai Nationality in Dali: The Yunnan Minority Eye Study

Zhong, Hua; Cha, Xueping; Tao, Wei; Lin, Xianchai; Li, Xun; Li, Jun; Cai, Ning; Li, Juanjuan; Su, Xiaodan; Yong-ming, Yang; Yu, Minbin; Yuan, Yuansheng

doi:10.1167/iovs.11-8947

Cited by 68 publications

(89 citation statements)

References 27 publications

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“…In our study, diabetes and hypertension were not correlated with the onset of pyterigium, and a study conducted in China confirms our results in a sample of 2742 patients (Zhong et al, 2012).…”

Section: Discussionsupporting

confidence: 89%

Pterygium in patients from Goiânia, Goiás, Brazil

Reis¹,

Júnior²,

Silva³

et al. 2015

Genet. Mol. Res.

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ABSTRACT. Pterygium is an inflammatory and degenerative ocular surface disease in which the conjunctiva on the cornea grows to form a fibrous tissue in the shape of a triangle. The disorder may be characterized by cell proliferation, inflammatory processes, fibrosis, angiogenesis, and destruction of the extracellular matrix. The anomaly is considered a degenerative eye disease and is erroneously confused with cataract. It displays similar features to those of tumors, such as local invasion, metaplasia of epithelial cells, presence of oncogenic viruses (human papilloma virus), inactivation of tumor suppressor genes (e.g., p53), and loss of heterozygosity. The treatment of pterygium is based on factors such as the evolution and progression of the disease, risk factors, symptoms, and patient age. Considerations about the best technique for the surgical removal of pterygium remain controversial, and complications and recurrence are very common. The development of new surgical techniques and adjuvant drugs is thus necessary. This study aims to analyze and compare the frequency of the GSTT1 genotypes in relation to pterygium through statistical analyzes 6183 Pterygium in patients from Goiânia, Goiás, Brazil ©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 14 (2): 6182-6188 (2015) in order to build a genotypic profile for the Replicon patients. The genotypic profile of the GSTT1-null polymorphism in Goiânia showed no significant difference when the frequency of the null genotype was compared between the control and experimental groups. The null genotype was more frequent in the population studied. Furthermore, the GSTT1 genotype was not related to the analyzed risk factors for pterygium, namely gender, ethnicity, family history, occupational exposure, smoking, hypertension, and diabetes.

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Section: Discussionsupporting

confidence: 89%

Pterygium in patients from Goiânia, Goiás, Brazil

Reis¹,

Júnior²,

Silva³

et al. 2015

Genet. Mol. Res.

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“…In a previous report, we have described the detailed methodology of YMES, [19][20][21][22] and the prevalence of pterygium in the baseline survey conducted in 2010, in Bai ethnicity. 19 In brief, random cluster sampling strategies were used to select ethnic Bai adults, aged 50 years or older, living in a rural community in the Yunnan Province located in southwest China (eastern longitude 99.589 and northern latitude 25.259). In the baseline survey, 2133 (77.8%) ethnic Bai adults were examined for the presence of pterygium.…”

Section: Study Cohortmentioning

confidence: 99%

“…19 In this analysis, we aim to assess the 5-year incidence of pterygium and its association with baseline predictors in this cohort.…”

mentioning

confidence: 99%

Five-Year Incidence and Predictors for Pterygium in a Rural Community in China

Zhong

Tian

et al. 2015

Cornea

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“…We also found that the presence of the GSTM1-null genotype did not increase the risk of developing pterygium when the patient had diabetes, and, in addition, we demonstrated that pterygium was not related to alcohol consumption. A study group from China (Zhong et al, 2012) assessed several parameters regarding the onset and development of pterygium such as height, weight (not evaluated by our group), hypertension, drinking, smoking, and diabetes. Their results support our results: there was no statistical significance between pterygium and diabetes or alcohol consumption.…”

Section: Discussionmentioning

confidence: 99%

Analysis of the GSTM1-null polymorphism in patients with pterygium from Goiânia, Goiás Brazil

et al. 2015

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ABSTRACT. The first reports about pterygium date back to Hippocrates, and this disease still threatens vision health around the world. Pterygium is a formation of fibrous tissue consisting of highly vascularized epithelial and subepithelial tissue that grows excessively and with an abnormal shape on the cornea. Many physical and biological factors are associated with the pathogenesis of pterygium, including heat, dust, and other particles in the atmosphere, and immunological mechanisms, mechanisms involving extracellular matrix reorganization, growth factors, cytokines, apoptosis, and angiogenesis. The aim of this study was to further investigate the association between polymorphisms in GSTM1 and the formation of pterygium. We collected peripheral blood samples from 90 patients diagnosed with pterygium and from 23 subjects without the disease in order to perform molecular analysis of the GSTM1 gene. Subjects with one or two copies of the GSTM1 allele had a normal genotype while those without any copies of the allele had a null genotype. The chi-square test or the Fisher exact test was performed in order to investigate possible associations between the molecular analysis and the risk of pterygium. A significant difference between the frequency of the GSTM1-null genotype in patient and control groups was identified. However, sub-group analysis found that the GSTM1-null genotype was statistically significant in men, but not in women, and in Caucasians, but not in Brown or Black groups. Furthermore, the GSTM1-null genotype was not related to any of the risk factors analyzed: cases in family, occupational exposure, smoking, hypertension, and diabetes.

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Prevalence of and Risk Factors for Pterygium in Rural Adult Chinese Populations of the Bai Nationality in Dali: The Yunnan Minority Eye Study

Abstract: The prevalence of pterygium in Dali is 39.0% among Chinese Bai aged 50 years and older. Independent associations with increasing age (>59 years), female sex, lack of education, and occupations linked to outdoor work suggest a multifactorial cause of this condition.

Cited by 68 publications

References 27 publications

Pterygium in patients from Goiânia, Goiás, Brazil

Pterygium in patients from Goiânia, Goiás, Brazil

Five-Year Incidence and Predictors for Pterygium in a Rural Community in China

Analysis of the GSTM1-null polymorphism in patients with pterygium from Goiânia, Goiás Brazil

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