Prevalence of albuminuria and renal dysfunction, and related clinical factors in Japanese patients with diabetes: The Japan Diabetes Complication and its Prevention prospective study 5

Abstract

Aims/Introduction To clarify the prevalence of albuminuria and renal dysfunction, and related factors in Japanese patients with diabetes, we analyzed the baseline data of the Japan Diabetes Complication and its Prevention prospective study. Materials and Methods We used the data of 355 patients with type 1 diabetes and 5,194 patients with type 2 diabetes to evaluate the prevalence of albuminuria and renal dysfunction, and related factors. A binomial logistic regression analysis was used to investigate independent contributing factors for estimated glomerular filtration rate <60 mL/min/1.73 m2 or albuminuria. Results The prevalence of microalbuminuria and macroalbuminuria was 15.2% (54/355) and 3.1% (11/355) in type 1 diabetes patients, and 25.0% (1,298/5,194) and 5.1% (265/5,194) in type 2 diabetes patients, respectively. The proportion of renal dysfunction (estimated glomerular filtration rate <60 mL/min/1.73 m2) was 9.9% (35/355) in type 1 diabetes patients, and 15.3% (797/5,194) in type 2 diabetes patients. The proportion of patients with renal dysfunction with normoalbuminuria was 7.3% (26/355) for type 1 diabetes patients, and 9.0% (467/5,194) for type 2 diabetes patients. The factors related to albuminuria in type 2 diabetes patients were glycated hemoglobin, hypertension, age, duration of diabetes, body mass index and estimated glomerular filtration rate. In contrast, factors to related renal dysfunction were age, duration of diabetes, dyslipidemia, hypertension, body mass index, male sex and albuminuria. Conclusions We showed the recent prevalence of albuminuria and renal dysfunction, and related factors in Japanese type 1 and type 2 diabetes patients using the baseline data of the Japan Diabetes Complication and its Prevention prospective study. The current results suggest that renal disease in patients with type 2 diabetes is heterogeneous, and different mechanisms might be involved in albuminuria and deterioration of renal function.

Type 2 Diabetes, Atrial Fibrillation, and Direct Oral Anticoagulation

“…Another cross-sectional survey in Chinese rural residents (including 23,869 participants) demonstrated that the overall prevalence of chronic kidney disease in participants with diabetes was 35.5% [63]. Additionally, the high prevalence of abnormal kidney function among diabetic patients has been consistently reported in populations living in the United States [62], United Arab Emirates [64], Japan [65], Palestine [66], China [63, 67], Taiwan [68], and Europe [69–71]. Moreover, T2D probably predicts progression of chronic kidney disease, and the presence of diabetic kidney disease seems to be associated with poor cardiovascular risk profile, especially in elderly individuals [71, 72].…”

Development and Worsening of Diabetes Among Adults Aged Over 40 Years: A 6-Year Follow-Up Study of 140,000 People in Japan – The Shizuoka Study

“…Finally, those with type 1 and 2 diabetes were not differentiated in our study. However, most of the people aged 40 and older who were diagnosed with diabetes were likely to have type 2 diabetes because of its higher prevalence in the general population (approximately 95%) [23,24]; hence, it can be assumed that most of the participants who initiated treatment in this study had type 2 diabetes.…”

Impact of sodium–glucose cotransporter 2 inhibitors on renal function in participants with type 2 diabetes and chronic kidney disease with normoalbuminuria

“…Recently, it was reported that the incidence of low eGFR with normoalbuminuria has been increasing in type 2 diabetes [10,12,13]. Pathological findings revealed that tubulointerstitial and vascular lesions tended to be more advanced in participants with type 2 diabetes and CKD with normoalbuminuria than those in participants with microalbuminuria or macroalbuminuria [11,14,15].…”