Prevalence, awareness, treatment, and control of dyslipidemia in Chinese adults: a systematic review and meta-analysis

Abstract

BackgroundResearchers have conducted a considerable number of epidemiological studies on dyslipidemia in China over recent years. Nevertheless, a representative study to comprehensively appraise for the epidemiological status of dyslipidemia is still lacked. This meta-analysis is intended to explore the pooled prevalence, rates of awareness, treatment, and control of dyslipidemia among adults in Chinese Mainland.Materials and methodsA systematic review was performed on relevant cross-sectional studies published since January 2012 by searching six authoritative literature databases. Meta-analyses were conducted in included studies based on a random-effect model to summarize the epidemiological status of dyslipidemia in China. A potential source of heterogeneity was detected by subgroup analysis and meta-regression. Publication bias was assessed by Egger's test and funnel plots. A sensitivity analysis was conducted to examine the study quality's influence on the pooled estimate of prevalence and rates of awareness, treatment, and control.ResultsForty-one original researches with a total of 1,310,402 Chinese participants were finally included in the meta-analysis. The prevalence, rates of awareness, treatment, and control of dyslipidemia were 42.1%, 18.2%, 11.6%, and 5.4%, respectively. With a pooled prevalence estimate at 24.5%, low HDL-C was the most prevalent among various dyslipidemia types, followed by hypertriglyceridemia (TG) (15.4%), hypercholesterolemia (TC) (8.3%), and high LDL-C (7.1%). The pooled prevalence of elevated serum lipoprotein(a) [Lp(a)] was 19.4%. By gender, the prevalence of dyslipidemia was 47.3% in males and 38.8% in females. Subgroup analyses revealed that the prevalence in southern and urban areas were higher than their counterparts. Females and population in urban areas tended to possess higher rates of awareness, treatment, and control. Meta-regression analyses suggested that the year of screening influenced prevalence estimates for dyslipidemia. The impact of the study's quality on the pooled estimates is insignificant.ConclusionOur study suggested a severe epidemic situation of dyslipidemia among adults in Chinese Mainland. More importantly, the awareness, treatment, and control rates were extremely low, revealing that dyslipidemia is a grave health issue. Consequently, we should attach more importance to the management of dyslipidemia, especially in economically underdeveloped areas.Systematic review registrationPROSPERO [CRD42022366456].

Vitamina D y perfil lipídico en adultos de la ciudad de Babahoyo, año 2023

“…En un metanálisis reciente sobre dislipidemias en adultos chinos, se encontró una estimación de prevalencia agrupada del 24,5%, el HDL-C bajo fue el más prevalente entre los distintos tipos de dislipidemia, seguido de hipertrigliceridemia (15,4%), hipercolesterolemia (8,3%) y LDL-C alto (7,1%) (41). Asimismo, la prevalencia general de dislipidemia en adultos en Bangladesh, fue del 76,7%; el 35,7% mostró un nivel alto de TG, el 18,5% mostró un nivel alto de LDL-C, el 63,8% mostró un nivel bajo de HDL-C y el 7,2% de los participantes mostró las tres anomalías lipídicas (42).…”

Comprehensive meta‐analysis of the effects of oral medroxyprogesterone acetate plus conjugated equine oestrogens on the lipid profile in women: Insights from randomized controlled trials

“…This might be related to the low awareness regarding dyslipidaemia in adults, despite the fact that females seem to be more conscious versus men about this cardiometabolic disorder. 85 Moreover, women who were already suffering from hypertriglyceridaemia might have been more aware of their lipid profile and tended to seek active measures, for example, lifestyle changes, to prevent supplementary elevations in serum TG concentrations, as previous investigations have depicted that hypertriglyceridaemia is higher in patients who display little knowledge regarding the major cardiovascular risk factors. 86 Moreover, the dose-response meta-analysis pointed out negative correlations between the changes in TG and HDL-C concentrations and MPA dosage, revealing that administration of MPA for less than 12 weeks actually decreased TG levels, possibly suggesting that short-term prescription of MPA may also be of aid to females with hypertriglyceridaemia.…”

“…Interestingly, TG increased predominantly in females younger than 60 years and in those who were not suffering from hypertriglyceridaemia before RCT enrolment. This might be related to the low awareness regarding dyslipidaemia in adults, despite the fact that females seem to be more conscious versus men about this cardiometabolic disorder 85 . Moreover, women who were already suffering from hypertriglyceridaemia might have been more aware of their lipid profile and tended to seek active measures, for example, lifestyle changes, to prevent supplementary elevations in serum TG concentrations, as previous investigations have depicted that hypertriglyceridaemia is higher in patients who display little knowledge regarding the major cardiovascular risk factors 86 .…”