Prevalence and significance of acanthosis nigricans in an adult obese population

Hud, J. A.

doi:10.1001/archderm.128.7.941

Cited by 34 publications

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“…[22] In another study,[21] a positive correlation between BMI and leptin was found. In another study,[34] skin tag was found in up to 74% of patients, and their prevalence correlated positively with the severity of the obesity. Similarly, 53.9% and 33.6% of patients with skin tags were overweight and obese.…”

Section: Discussionmentioning

confidence: 94%

A comparison study of lipid profile levels between skin tags affected people and normal population in Tehran, Iran

et al. 2014

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Background:For many years the association of skin tags and endocrynopathies has been postulated, although many reports are available but it has never been evaluated to mean normal population. Dyslipidemia is a frequent disorder among people and seemed to be necessary for screening within skin tag condition. This study is designed to find any possible association between skin tags and dyslipidemia.Materials and Methods:From April 2009 to June 2011, 168 patients enrolled the study. Among the remaining 152 patients, there were 89 females (58.5%) and 63 males (%41.5). Based on the TLGS study 136 men and 220 women enrolled the control group of study. The mean age was 28.4 years. Patients trained to have normal free diet for at least 1 month then referred to the laboratory. Blood samples were taken over 12 hours fasting with 2 hours intervals. Hypertriglyceridemia was defined as plasma level ≥160 mg/dl for men and ≥130 mg/dl for women. Hypercholesterolemia pointed at its value >200 mg/dl. Normal HDL levels was defined as >39 mg/dl for men and >35 mg/dl to women.Results:Mean skin tag number was 12.6 per subject. The most frequent localizations of skin tags were neck and upper chest (mean number: 13.4, 48.9%) followed by axilla (mean number: 11.6, 33%) and breast (10.2, 10.1%) in the patient group. The mean cholesterol level of case group was 192.2 ± 33.1 mg/dl, while it was 187.0 ± 42 mg/dl in the control group). The mean ± SD for triglyceride was 132.1 ± 69 mg/dl in comparison to 129 ± 74 in the control group.Conclusion:The study showed no significant differences between normal population and patients’ lipid profile.

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Section: Discussionmentioning

confidence: 94%

A comparison study of lipid profile levels between skin tags affected people and normal population in Tehran, Iran

et al. 2014

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“…The prevalence in whites is less than 1%. In Hispanics, the prevalence is 5.5%, and, in African Americans, the prevalence is the highest at 13.3% 7, 9, 22 . However, in this study, the prevalence of acanthosis nigricans among head and neck patients was 0.003%.…”

Section: Discussionmentioning

confidence: 96%

“…The actual prevalence of the disease is unknown. Various researchers had reported different prevalence of the disease in different regions of the world 7, 22 . Acanthosis nigricans is much more common in people with darker skin pigmentation 9 .…”

Section: Discussionmentioning

confidence: 99%

“…The mode of inheritance has not been established, however, autosomal recessive or polygenic inheritance has been proposed 6 . Acanthosis nigricans is most commonly associated with being overweight (BMI >25 kg/m 2 ) and it is frequently found in people with diabetes 7-10 . The stimulating factor is probably insulin or an insulin-like growth factor that incites the epidermal cell propagation.…”

Section: Introductionmentioning

confidence: 99%

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Acanthosis nigricans in the head and neck region

Fasunla¹,

Ijaduola²

2011

Ann. Ibadan Postgrad. Med.

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Background: The sudden appearance of acanthosis nigricans on the skin of an individual is highly suggestive of an underlying clinical disease. However, there is no information on its possible association with head and neck disease in our environment.Objective: To determine the prevalence of acanthosis nigricans and identifying the underlying associated medical and oncologic factor in an Otorhinolaryngologic, head and neck practice.Method: This was a 12-month prospective study of patients seen at Otorhinolaryngology department of University College Hospital, Ibadan. Relevant clinical, anthropometric and biochemical information were obtained with an interviewer assisted questionnaire and data analyzed using descriptive statistics.Results: Of 764 patients, 85(11.13%) had head and neck malignancies, 15(1.96%) had diabetes mellitus in addition to the Otorhinolaryngologic, head and neck diseases. The body mass index values for male and female ranged from 18.26 – 25.68kg/m2 and 17.94 – 30.25kg/m2 respectively. Only two patients, one with nasopharyngeal cancer and the other with obesity in addition to chronic rhinosinusitis had acanthosis nigricans.Conclusion: Acanthosis nigricans is not common among Otorhinolaryngologic patients in our clinical setting with a prevalence of 0.003. Nevertheless, its presence should herald the suspicion of an underlying metabolic or oncologic disease.

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“…Every year, this project screens tens of thousands of children for BMI. The screening staff also explores the base of the child’s neck and axilla for evidence of Acanthosis Nigricans (Figure 3) – a hyperpigmented skin rash associated with insulin resistance and hyperinsulinemia in children [17] - and a blood sample is drawn from 5 th grade students only to obtain a fasting lipid profile. Prior to screening day, all participating parents provide demographic and family history information by completing a questionnaire.…”

Section: Metabolic Origins Of Asthmamentioning

confidence: 99%

Metabolic Asthma

Perez

Piedimonte

2014

Immunology and Allergy Clinics of North America

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SYNOPSIS Childhood asthma and obesity have reached epidemic proportions worldwide, and the latter is also contributing to increasing rates of related metabolic disorders like diabetes. Yet, the relationship between asthma, obesity, and abnormal metabolism is not well understood, nor has it been adequately explored in children. This article discusses the concept of “metabolic asthma” and the recent hypothesis that early derangement in lipid and glucose metabolism is independently associated to increased risk for asthma.

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Prevalence and significance of acanthosis nigricans in an adult obese population

Cited by 34 publications

References 0 publications

A comparison study of lipid profile levels between skin tags affected people and normal population in Tehran, Iran

A comparison study of lipid profile levels between skin tags affected people and normal population in Tehran, Iran

Acanthosis nigricans in the head and neck region

Metabolic Asthma

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