Prevalence and risk factors of actinic keratoses in Germany – analysis of multisource data

Schaefer, Ines; Augustin, Matthias; Spehr, C.; Reusch, Michael; Kornek, Thomas

doi:10.1111/jdv.12102

Cited by 100 publications

(92 citation statements)

References 20 publications

(40 reference statements)

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“…DOI: 10.1159/000491820 that demonstrated a high incidence rate of AK among outdoor workers [2,3,13,14]. From the AK lesion localization it can be deduced that the head is the most affected area of the body.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Actinic Keratosis in Patients Attending General Practitioners in Switzerland

Dziunycz

Schüller²,

Hofbauer

2018

Dermatology

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Background: Most of the data concerning the prevalence of actinic keratosis (AK) originate from the USA and Australia, and recently from Austria and Spain, but are based on populations in dermatology practices. Switzerland is the leading country with skin cancer incidence in Europe. AK prevalence among the Swiss population is therefore an important public health issue. Objective: To assess the prevalence of AK in the outpatient Swiss population in general practice. Methods: General practitioners captured AK diagnosis stage and localization in consecutive patients, who attended the physician for any reason. Results: A total of 2,844 consecutive patients (55.7% female) were enrolled in 59 general practitioners’ offices. AK prevalence was 25.3% and increased steadily with age; 33% of men and 19% of women were diagnosed with AK. Every second AK patient declared leisure-related UV exposure, while only 23% were exposed to UV occupationally; 16% of the patients were UV exposed both occupationally and during leisure. AK distribution among sun-exposed body sites and extent of disease varied by sex. Conclusion: In Switzerland AK is a common diagnosis in dermatology practices. Since up to 5% of AK may progress to invasive squamous cell carcinoma (SCC), prevention of AK, as well as education of patients and general practitioners, may play a critical role for subsequent SCC development. This is the first study on AK prevalence in Switzerland identifying patients most affected by AK. These results will help to define future approaches to target general practitioners for education, screening, and specific intervention in patients with AK.

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Section: Discussionmentioning

confidence: 99%

Prevalence of Actinic Keratosis in Patients Attending General Practitioners in Switzerland

Dziunycz

Schüller²,

Hofbauer

2018

Dermatology

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“…Im Jahr 2011 entfielen auf die AK 8,3% der 100 am häufigsten behandelten dermatologischen, ambulanten Diagnosen in Deutschland, wobei der Anteil der AK-Fäl-le im Vergleich zu anderen dermatologischen Erkrankungen in den letzten 10 Jahren nahezu kontinuierlich gestiegen ist [4]. Chronische langfristige Sonneneinstrahlung ist der Hauptrisikofaktor für das Auftreten von AK [5].…”

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Neue Strategien in der Prävention der aktinischen Keratose: Eine kritische Literaturanalyse

Krutmann¹,

Berking²,

Berneburg³

et al. 2016

Kompass Dermatol

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Aktinische Keratose (AK) - epidermale dysplastische Läsionen nach chronischer Exposition gegenüber Sonneneinstrahlung - ist bei Personen mit hellerer Haut sehr verbreitet; die chronische Langzeit-UV-Exposition ist hierbei der Hauptrisikofaktor. Angesichts der Alterung der Bevölkerung ist zu erwarten, dass die Prävalenz der AK weiter steigen wird. AK kann zu nicht-melanomatösem Hautkrebs (NMSC) progredieren und stellt ein relevantes Problem der öffentlichen Gesundheit dar. Sechs führende Dermatologen aus Deutschland mit Spezialisierung auf AK und NMSC kamen zusammen, um über das Wesen der Erkrankung sowie die Präventions- und Behandlungsstrategien zu diskutieren, die dem Dermatologen heute zur Verfügung stehen. Während kosmetische Sonnenschutzmittel einen wesentlichen Bestandteil der Sonnenschutzstrategien darstellen, sind sie nicht ausreichend, wenn bereits Schädigung eingetreten ist. Neu entwickelte Produkte aus der Kategorie der Medizinprodukte bieten auch DNA-reparierende Eigenschaften zusätzlich zum UV-Schutz mit hohem Lichtschutzfaktor. Für die adjuvante Behandlung der AK in verschiedenen Risikostufen wurde ein Algorithmus entwickelt. Für Patienten mit niedrigem bis mittlerem Risiko wird reiner Sonnenschutz empfohlen. Für Patientengruppen mit hohem bis sehr hohem Risiko wird die ganzjährige Anwendung von Medizinprodukten empfohlen, die sehr hohen Lichtschutz mit Korrektur von Lichtschäden (durch DNA-Reparaturenzyme) kombinieren.

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“…The prevalence in the USA ranges from 11 to 26% [3], whilst in Europe 15% of men and 6% of women have been reported to be affected [3]. In Germany a recent study estimated the standardized prevalence of AK from dermatological examinations at 2.7%, with prevalence increasing with age (11.5% in the group 60-70 years) [4]. The prevalence, which is at the lower limit of studies from other countries, suggests about 1.7 million estimated AK cases documented by dermatologists in Germany.…”

Section: Introductionmentioning

confidence: 99%

“…The prevalence, which is at the lower limit of studies from other countries, suggests about 1.7 million estimated AK cases documented by dermatologists in Germany. In 2011, AK accounted for 8.3% of the 100 most frequently treated dermatological outpatient diagnoses in Germany, with the proportion of AK cases rising almost continuously over the last 10 years compared to other dermatological conditions [4]. Chronic long-term sun exposure is the major risk factor for AK [5].…”

Section: Introductionmentioning

confidence: 99%

New Strategies in the Prevention of Actinic Keratosis: A Critical Review

Krutmann

Berking

Berneburg

et al. 2015

Skin Pharmacol Physiol

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Actinic keratosis (AK) or lesions of epidermal dysplasia occurring in skin chronically exposed to solar radiation is very prevalent in lighter skin persons, with chronic long-term sun exposure being the major risk factor. With an aging population it is expected that the prevalence of AK will further increase. AK can progress to nonmelanoma skin cancer (NMSC) and is a public health concern. Six leading dermatologists with expertise in AK and NMSC from Germany met to discuss the nature of the disease and the prevention and treatment strategies available to dermatologists today. While cosmetic sunscreen products form an essential element of sun protection strategies, they are not adequate when damage has already been inflicted. Newly developed products of the medical device category offer DNA repair function paired with high sun protection factor (SPF) UV protection. An adjuvant treatment algorithm for various risk levels of AK was developed. For patients with low and moderate risk, sunscreen only is recommended. For patient groups with high and very high risk, a very high photoprotection and photorepair action (DNA repair enzymes) in medical device products all year round is recommended.

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Prevalence and risk factors of actinic keratoses in Germany – analysis of multisource data

Abstract: Actinic keratosis is a frequent condition in higher age groups and more prevalent in men; a relevant need for health care is evident. Predictors and risk factors for AK are easy to identify in the population, which could also help to detect groups with special need for preventive measures.

Cited by 100 publications

References 20 publications

Prevalence of Actinic Keratosis in Patients Attending General Practitioners in Switzerland

Prevalence of Actinic Keratosis in Patients Attending General Practitioners in Switzerland

Neue Strategien in der Prävention der aktinischen Keratose: Eine kritische Literaturanalyse

New Strategies in the Prevention of Actinic Keratosis: A Critical Review

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