Prevalence and risk factors of small airway dysfunction, and association with smoking, in China: findings from a national cross-sectional study

Bai, Chunxue; Sun, Tieying; Zhang, Hong; Zhang, Xiaolei; An, Li; Wang, Chen; He, Jiang; Xu, Jun‐Fa; Yang, Lan; Xu, Yongjian; Zhang, Xiangyan; Bai, Chenxue; Kang, Jian; Ran, Pixin; Shen, Huahao; Wen, Fuqiang; Huang, Kewu; Yao, Wan-zhen; Shan, Guangliang; Lin, Yingxiang; Wu, Sinan; Zhu, Jianguo; Wang, Ruiying; Shi, Zhihong; Zhao, Jianping; Ye, Xianwei; Song, Yuanlin; Yan, Dong; Wang, Qiuyue; Hou, Gang; Zhou, Yumin; Li, Wen; Ding, Liren; Wan, Chun; Yang, Ting; Wang, Hao; Chen, Yahong; Guo, Yanfei; Xiao, Fei; Lü, Yong; Peng, Xiaoxia; Zhang, Biao; Xiao, Dingquan; Wang, Zuomin; Bu, Xiaoning; Zhang, Hong; Zhang, Xiaolei; Zhang, Shu; Cao, Zhixin; Zhan, Qingyuan; Yang, Yuanhua; Cao, Bin; Dai, Huaping; Liang, Lirong; Wang, Chaolong; Tong, Xunliang; Wu, Tangchun; Kan, Haidong; Chen, Renjie; Cai, Hua; Xiong, Weining; Zhang, Pengjun; Li, Yong; Niu, Wenquan; Chen, Chung-Shiuan; Xu, Guodong; Zhang, Xinran; Gu, Xiaoqing; Dong, Fen; Liu, Zhao; Cheng, Anqi; Pei, Zhengcun; Niu, Hongtao; Huang, Ke; Chen, Simiao; Chung, Kian Fan; Chen, Zhengming

doi:10.1016/s2213-2600(20)30155-7

Cited by 90 publications

(122 citation statements)

References 39 publications

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“…Second, most of the participants in the DFTJ cohort were elder retirees, which limited representativeness for the younger Chinese population. However, the general characteristics and SII level among the DFTJ cohort participants were comparable with that reported in the general middle-aged and older Chinese population 37 , 38 . Thirdly, our results might be affected by reverse causation or residual confounding.…”

Section: Discussionsupporting

confidence: 72%

Physical activity attenuates the associations of systemic immune-inflammation index with total and cause-specific mortality among middle-aged and older populations

Bai

et al. 2021

Sci Rep

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Systemic immune-inflammation index (SII) emerged as a biomarker of chronic inflammation and an independent prognostic factor for many cancers. We aimed to investigate the associations of SII level with total and cause-specific mortality risks in the general populations, and the potential modification effects of lifestyle-related factors on the above associations. In this study, we included 30,521 subjects from the Dongfeng-Tongji (DFTJ) cohort and 25,761 subjects from the National Health and Nutrition Examination Survey (NHANES) 1999–2014. Cox proportional hazards regression models were used to estimate the associations of SII with mortality from all-cause, cardiovascular diseases (CVD), cancer and other causes. In the DFTJ cohort, compared to subjects in the low SII subgroup, those within the middle and high SII subgroups had increased risks of total mortality [hazard ratio, HR (95% confidence interval, CI) = 1.12 (1.03–1.22) and 1.26 (1.16–1.36), respectively) and CVD mortality [HR (95%CI) = 1.36 (1.19–1.55) and 1.50 (1.32–1.71), respectively]; those within the high SII subgroup had a higher risk of other causes mortality [HR (95%CI) = 1.28 (1.09–1.49)]. In the NHANES 1999–2014, subjects in the high SII subgroup had higher risks of total, CVD, cancer and other causes mortality [HR (95%CI) = 1.38 (1.27–1.49), 1.33 (1.11–1.59), 1.22 (1.04–1.45) and 1.47 (1.32–1.63), respectively]. For subjects with a high level of SII, physical activity could attenuate a separate 30% and 32% risk of total and CVD mortality in the DFTJ cohort, and a separate 41% and 59% risk of total and CVD mortality in the NHANES 1999–2014. Our study suggested high SII level may increase total and CVD mortality in the general populations and physical activity exerted a beneficial effect on the above associations.

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Section: Discussionsupporting

confidence: 72%

Physical activity attenuates the associations of systemic immune-inflammation index with total and cause-specific mortality among middle-aged and older populations

Bai

et al. 2021

Sci Rep

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“…Studies have indicated that the acute respiratory distress syndrome (ARDS) resulted from the cytokine storm syndrome is a major cause of death in COVID-19 patients. In cytokine storm, the level of pro-inflammatory cytokines (IL-1, IL-6, TNF-α) and chemokines (CCL2, CCL3, CXCL10, CXCL9) increase, thereby causing the hyperactivity of the immune system and acute lung injury (ALI) [ 32 ].…”

Section: Microalgae and Covid-19 Treatmentmentioning

confidence: 99%

Microalgae: therapeutic potentials and applications

et al. 2021

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Recently, special attention has been paid to marine origin compounds such as carbohydrates, peptides, lipids, and carotenoids, which are extracted from microalgae and have anticancer, anti-inflammatory, antimicrobial (e.g., anti-COVID-19 activity), and antioxidant properties in biomedicine and pharmaceutical biotechnology. In addition, these photosynthetic marine microorganisms have several applications in biotechnology and are suitable hosts for the production of recombinant proteins/peptides, such as monoclonal antibodies and vaccines. Silica-based nanoparticles obtained from diatoms (a microalgae group) are used as drug delivery carriers owing to their biodegradability, easy functionalization, low cost, and simple features compared to synthetics, which make these agents proper alternatives for synthetic silica nanoparticles. Therefore, diatom-based nanoparticles are a viable option for the delivery of anti-cancer drugs and reducing the side-effects of cancer chemotherapy.

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“…In addition, concomitant injury of liver has recently been published in COVID-19 patients (Zhang et al 2020a ). The abnormality of function tests of liver were seen in some patients with COVID-19 upon admission (Xiao et al 2020 ). A group of liver function tests was performed, and the results revealed that some COVID-19 patients had liver dysfunction.…”

Section: Liver In Pathogenesis Of Covid-19mentioning

confidence: 99%

Revealed pathophysiological mechanisms of crosslinking interaction of affected vital organs in COVID-19

et al. 2021

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SARS-CoV-2 is one of the main serious challenges of human societies, which emerged in December 2019 from China and quickly extends to all parts of the world. The virus was previously believed to only affect the lungs and respiratory system, but subsequent research has revealed that it affects a variety of organs. For this reason, this disease is known as a multiorgan disease. Current article aimed to highlight latest information and updates about molecular studies regarding pathogenesis of SARS-CoV-2 in kidney, liver, and cardiovascular and respiratory systems, as well as the mechanisms of interaction of these organs with each other to cause clinical manifestations in patients.

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Prevalence and risk factors of small airway dysfunction, and association with smoking, in China: findings from a national cross-sectional study

Cited by 90 publications

References 39 publications

Physical activity attenuates the associations of systemic immune-inflammation index with total and cause-specific mortality among middle-aged and older populations

Physical activity attenuates the associations of systemic immune-inflammation index with total and cause-specific mortality among middle-aged and older populations

Microalgae: therapeutic potentials and applications

Revealed pathophysiological mechanisms of crosslinking interaction of affected vital organs in COVID-19

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