Prevalence and Risk Factors of Functional Gastrointestinal Disorders: A Cross-Sectional Study in Italian Infants and Young Children

Scarpato, Elena; Salvatore, Silvia; Romano, Claudio; Bruzzese, Dario; Ferrara, Dante; Inferrera, Ramona; Zeevenhooven, Judith; Steutel, Nina F; Benninga, Marc A.; Staiano, Annamaria

doi:10.1097/mpg.0000000000003653

Cited by 6 publications

(10 citation statements)

References 24 publications

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“…This phenomenon was possibly attributed to reduced sibling rivalry and competition, leading to lower stress levels, and increased individual attention from parents. 79 Though we showed that the presence of siblings had no impact on constipation prevalence, it did identify an association between compromised mental health and an increased constipation prevalence in children in Asia. Therefore, further research is needed to understand the precise mechanisms underlying the relationship between constipation and mental health in children.…”

Section: Discussionmentioning

confidence: 54%

Prevalence and determinants of constipation in children in Asia: a systematic review and meta-analysis

Djurijanto,

Lin,

et al. 2024

eClinicalMedicine

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Section: Discussionmentioning

confidence: 54%

Prevalence and determinants of constipation in children in Asia: a systematic review and meta-analysis

Djurijanto,

Lin,

et al. 2024

eClinicalMedicine

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“…However, the conducted study showed a relationship between the age of the parents, smoking of the mother and hypodynamia of the mother during pregnancy, a positive history of the parents regarding functional diseases of the gastrointestinal tract, hypoxic-ischemic lesions of the central nervous system and body weight at birth of 2900 g and less and intestinal colic in infants. The importance of the influence of these factors was partially confirmed in the study [21].…”

Section: Discussionmentioning

confidence: 58%

Effectiveness of Postural Therapy in Infants With Frequent Intestinal Colic

Sorokman

Ostapchuk

2023

Neonatol. hìr. perinat. med.

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Infantile colic is a general term used to describe excessive crying, abdominal pain, and discomfort in the first months of life, and it causes stress for parents and concern for clinicians. Colic in babies is common all over the world. The Rome criteria offer diagnostic criteria for functional gastrointestinal symptoms but do not discuss their treatment. Manipulative treatments are considered effective interventions to reduce the severity of symptoms.The aim of the study. To evaluate the effectiveness of postural therapy in infants with intestinal colic.Methods. The current prospective cohort study used data from a mother-child cohort. 37 "mother-child" pairs (age of babies from 2 weeks to 4 months) were under observation. Two observation groups were created by the method of simple randomization: Group I - 17 infants who received traditional therapy (preparations based on simethicone, prokinetics, enzymes, antispasmodics, in case of significant flatulence, a gas removal tube or microenema was used), Group II - 20 infants who received postural therapy.To reveal the statistical difference between indicators in groups distributed normally, the Student's t-criterion of reliability was used, the degree of significance - r. The probability of the difference between relative values was determined by the Fisher's angular transformation method (Рφ).The research design and all the methods used in this study were reviewed and approved by the bioethics commission of the Bukovinian State Medical University (protocol No. 8, dated 02/17/2023).The study was carried out as part of the research work «Early diagnosis, treatment and prevention of combined pathology of the gastrointestinal tract and thyroid gland in children» (state registration number 0116U002937, implementation period 02.2016-11.2022).Results of the study. In 81.1% of babies, colic started after the 2nd week of life, in 18.9% - after the 1st month of life. The average age of onset of symptoms was 1.1 ± 0.1 months. Initially, colic occurred less often (1-2 times a week) and lasted up to 15 minutes, with age, their frequency and duration increased. We identified the main risk factors for the development of colic in babies: younger age of parents (F = 0.529, p = 0.001), mother's smoking (F = 0.498, p = 0.01), hypodynamia of the mother during pregnancy (F = 0.511, p = 0 .02), positive history of the father regarding functional diseases of the gastrointestinal tract (F = 0.788, p= 0.004), positive history of the mother regarding functional diseases of the gastrointestinal tract (F = 0.489, p= 0.01), food allergy in the mother (Ф = 0.476, p = 0.02), food allergy in the father (F = 0.329, p = 0.05), early (up to 3 months) transfer of the child to mixed or artificial feeding (F = 0.324, p = 0.05), hypoxic-ischemic CNS damage (F = 0.467, p = 0.05), body weight at birth <2900 g (F = 0.531, p = 0.01). The dynamics of symptoms in children of both observation groups was almost the same, with the exception of such signs of colic as flatulence and grunting, which disappeared faster by 2.7±0.6 days in children who were on postural therapy. The frequency of colic attacks also decreased. Positive dynamics of body weight gain were noted in infants of both groups.Conclusions.1. The average age of onset of intestinal colic symptoms in infants was 1.1 ± 0.1 months.2. The relationship between the age of the parents, the mother's smoking and the mother's hypodynamia during pregnancy, a positive history of the parents regarding functional diseases of the gastrointestinal tract, hypoxic-ischemic lesions of the central nervous system and a birth weight of less than 2900 g and intestinal colic in infants was established.3. The use of postural therapy in infants with intestinal colic is an effective method of their treatment, which is confirmed by the positive dynamics of symptoms, a decrease in the frequency and duration of colic attacks, a sufficient increase in body weight and does not require the cost of medication.

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“…In 2023 Cenni et al conducted a study on 740 Italian children aiming to evaluate the prevalence of FGIDs; FC resulted to be the most frequent disorder with a prevalence of 18.2% using Rome IV criteria, with a higher prevalence in children than in adolescents [ 14 ]. Another Italian study showed a similar prevalence of FC (16.1%) in children aged between 13 and 48 months [ 15 ]. Overall, FC can be defined as a common problem in children with up to 25% of visits to pediatric gastroenterologists and 3% of all general pediatric outpatient visits are due to FC [ 16 ].…”

Section: What Is the Incidence?mentioning

confidence: 86%

“…Early child nutrition is also involved in FC: breastmilk has been reported to be a protective factor [ 15 , 21 , 32 ]. De Oliveira et al confirmed a potential association between infant milk-type and childhood constipation concluding that exclusive breastfeeding in the first 6 months of age is a protective factor for constipation, with early effects on stool consistency, and later in life through epigenetic mechanisms and/or behavioral pathways [ 33 ].…”

Section: What Is the Etiology?mentioning

confidence: 99%

The ten “hard” questions in pediatric functional constipation

Fedele,

Fioretti,

Scarpato

et al. 2024

Ital J Pediatr

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Functional constipation is a common problem in childhood and has a great impact on social, physical, and emotional functioning of affected children and their caregivers. No organic cause of the constipation can be found in approximately 95% of children, defining the “so-called” chronic functional constipation. Its prevalence has been reported to range from 0.7 to 29.6%, with a median of 12%. The diagnosis of functional constipation is exclusively clinical based on the pediatric diagnostic Rome criteria for functional gastrointestinal disorders and does not routinely require laboratory and/or radiological investigations. In case of alarm signs and symptoms that may suggest organic diseases, further investigations can be required. The therapeutic management is based on non-pharmacological and pharmacological approaches. Education, demystification of constipation and reward-based toilet training represent the cornerstones of nonpharmacological management. Disimpaction, maintenance treatment and weaning of medication are all elements of pharmacological treatment. Osmotic laxatives, mainly polyethylene glycol (PEG), are considered the first-choice laxative for both disimpaction and maintenance treatment. The aim of this review is to provide pediatric gastroenterologists with a practical tool to support the clinical and therapeutic management of children and adolescents affected by chronic functional constipation.

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Prevalence and Risk Factors of Functional Gastrointestinal Disorders: A Cross-Sectional Study in Italian Infants and Young Children

Cited by 6 publications

References 24 publications

Prevalence and determinants of constipation in children in Asia: a systematic review and meta-analysis

Prevalence and determinants of constipation in children in Asia: a systematic review and meta-analysis

Effectiveness of Postural Therapy in Infants With Frequent Intestinal Colic

The ten “hard” questions in pediatric functional constipation

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