Prevalence and Recovery From Olfactory and Gustatory Dysfunctions in Covid-19 Infection: A Prospective Multicenter Study

Chary, Eléonore; Carsuzaa, Florent; Trijolet, J.-P.; Capitaine, Anne‐Laure; Roncato‐Saberan, Mariam; Fouet, Kevin; Cazenave‐Roblot, F.; Catroux, M.; Allix‐Béguec, Caroline; Dufour, Xavier

doi:10.1177/1945892420930954

Cited by 115 publications

(194 citation statements)

References 22 publications

(37 reference statements)

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“…Fourth, regional differences in the veracity of SARS‐CoV‐2 and susceptibility of local populations to infection, as well as differences in subject characteristics and recruitment strategies, could be involved. For example, in accord with most COVID‐19 studies, 28 proportionately more men (67%) were present in our sample than in the other olfactory studies in which women predominated (eg, 30%, 29 35%, 7 37.5%, 16 and 57% 26 ). Given that women generally outperform men on olfactory tests, 30 and are more likely to volunteer for studies than men, 31 these differences could reflect survey recruitment biases.…”

Section: Discussionsupporting

confidence: 85%

“…Given the latter, our baseline metric for assessing change was the time of symptom onset. Although this metric has also been used in some self‐report surveys, 11,16 others have employed the time since first noticing chemosensory dysfunction, 15,25,29 which seems questionable in light of the inaccuracy of awareness. All such studies, however, are in general agreement with ours in noting that many patients regain function over relatively brief periods of time.…”

Section: Discussionmentioning

confidence: 99%

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Prevalence and reversibility of smell dysfunction measured psychophysically in a cohort of COVID‐19 patients

Moein

Hashemian

Tabarsi

et al. 2020

Int Forum Allergy Rhinol

113

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Background Considerable evidence suggests that smell dysfunction is common in coronavirus disease-COVID-Unfortunately extant data on prevalence and reversibility over time are highly variable coming mainly from self-report surveys prone to multiple biases Thus validated psychophysical olfactory testing is sorely needed to establish such parameters Methods One hundred severe acute respiratory syndrome-coronavirus-SARS-CoV-positive patients were administered the-item University of Pennsylvania Smell Identification Test UPSIT in the hospital near the end of the acute phase of the disease Eighty-two were retested or weeks later at home The data were analyzed using analysis of variance and mixed-effect regression models Results Initial UPSIT scores were indicative of severe microsmia with exhibiting measurable dysfunction were anosmic The scores improved upon retest initial test mean confidence interval CI retest mean CI-p < no patient remained anosmic A er weeks from COVIDsymptom onset the test scores of of the retested patients were normal However the mean UPSIT score at that time continued to remain below that of age-and sexmatched healthy controls p < Such scores were related to time since symptom onset sex and age Conclusion Smell loss was extremely common in the acute phase of a cohort of COVID-patients when objectively measured About one third of cases continued to exhibit dysfunction to weeks a er symptom onset These findings have direct implications for the use of olfactory testing in identifying SARS-CoV-carriers and for counseling such individuals with regard to their smell dysfunction and its reversibility © 2020 ARS-AAOA, LLC.

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Section: Discussionsupporting

confidence: 85%

Section: Discussionmentioning

confidence: 99%

Prevalence and reversibility of smell dysfunction measured psychophysically in a cohort of COVID‐19 patients

Moein

Hashemian

Tabarsi

et al. 2020

Int Forum Allergy Rhinol

113

View full text Add to dashboard Cite

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“…Patients with olfactory dysfunction (n = 121) seemed to be younger with a predominance of males and had fewer comorbidities. This finding was in contrast to the studies conducted earlier [22][23][24][25][26][27][28]. Males have greater predisposition to olfactory dysfunction because they have the higher likelihood of exposure to harmful agents.…”

Section: Olfactory Analysiscontrasting

confidence: 89%

Evaluation of Olfactory Acuity in Patients with Coronavirus Disease 2019 (COVID-19)

Shah

Hussain²,

Mustafa

et al. 2020

Indian J Otolaryngol Head Neck Surg

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Aim and Objectives To describe the prevalence and characteristics of olfactory dysfunction (OD) in patients with laboratory-confirmed COVID-19 infection. Materials and Methods This monocentric study was performed at Chest Diseases Hospital during the COVID-19 pandemic and all patients testing positive for COVID-19 over a 5-month period (April to August 2020) were recruited. Detailed history was elicited from subjects and all patients were inquired about olfactory dysfunction (OD). Patients with olfactory dysfunction were asked to complete olfactory questionnaires based on the short version of the Questionnaire of Olfactory Disorders-Negative Statements (sQOD-NS). Results 655 patients with mild to moderate COVID-19 infection were included in the study. The prevalence rate of olfactory dysfunction was 18.47% (n = 121) with contribution of 11.60% (n = 76) and 6.87% (n = 45) from anosmia and hyposmia respectively, thereby suggesting olfactory dysfunction to be a significant clinical feature in COVID-19 patients. Males were significantly more affected by olfactory dysfunctions than females. Anosmic patients had significantly reduced sQOD-NS results as compared to hyposmic patients (significant at P \ 0.05). The mean duration of OD was 7.7 days (± 4.3) and [90% patients in our study showed resolution within 14 days. Conclusion The early recognition of olfactory dysfunction should help to screen, identify and thereby quickly isolate mildly symptomatic COVID-19 patients from the general population and the existence of these dysfunctions may well be a prognostic factor in the course of the disease.

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“…Complete recovery of smell function was found in 64.9% of patients, while 34% reported only partial recovery. As reported by Chary et al (5), we also found no signi cant difference between the sexes concerning recovery of smell function. However, Paderno et al (4) found that later recovery of smell was more prevalent among women.…”

Section: Discussionsupporting

confidence: 85%

“…In this analysis, which is a follow-up to the previous study by Biadsee et al 1, we aimed to further understand the long term impact of the damage to the olfactory neuroepithelium caused by the COVID-19 virus. Chary et al (5) found that 70% of COVID-19 patients reported OD without nasal obstruction. Furthermore, 64% of their cohort had complete resolution of OD within 15 days after positive PCR diagnosis.…”

Section: Discussionmentioning

confidence: 99%

Prognostic Value of Olfactory and Gustatory Dysfunction As Initial Symptoms of COVID-19 Infection

Biadsee

Dagan

Ormianer

et al. 2020

Preprint

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Introduction: Olfactory and gustatory chemosensory dysfunctions are very prevalent in COVID-19 infection, our aim is to further explore chemosensory recovery among these patients.Methods: This is a cross-sectional follow-up study, which serves as a sequel to a study by Biadsee, et al. Among the previous study population of 128 non-hospitalized patients, who were tested positive for COVID-19 by reverse transcription-polymerase chain reaction (RT-PCR). Ninety-seven patients participated in a telephone survey designed for this study. Recovery of olfactory and gustatory functions were defined when a score is greater or equal to that reported before the disease. Persistent hyposmia and hypogeusia were defined as lower scores reported during follow-up, compared with scores before the disease. Results: A total of 43 men and 54 women were included. Mean age was 37 years (range 18-73). Mean follow-up was 59.2 days (range 21-83). At follow-up, 72 (74.2%) patients reported normalization of gustatory function and 63 (64.9%) reported normalization of olfactory function. No patient reported nasal obstruction at follow-up. Recovery of olfactory function was positively correlated with gustatory recovery (p=0.003). Twenty-three (23.7%) reported persistent xerostomia. Women who reported persistent xerostomia had higher rates of olfactory and gustatory dysfunction (p=0.006 and p=0.008, respectively) than those who did not. Olfactory and gustatory disorders as initial symptoms were negative prognostic factors for recovery. Conclusion: Olfactory and/or gustatory dysfunction as a presenting symptom of COVID-19 infection may be a negative prognostic factor for full recovery of olfactory and gustatory function.

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Prevalence and Recovery From Olfactory and Gustatory Dysfunctions in Covid-19 Infection: A Prospective Multicenter Study

Cited by 115 publications

References 22 publications

Prevalence and reversibility of smell dysfunction measured psychophysically in a cohort of COVID‐19 patients

Prevalence and reversibility of smell dysfunction measured psychophysically in a cohort of COVID‐19 patients

Evaluation of Olfactory Acuity in Patients with Coronavirus Disease 2019 (COVID-19)

Prognostic Value of Olfactory and Gustatory Dysfunction As Initial Symptoms of COVID-19 Infection

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